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A fast chemometrics approach to quantitative analysis of metformin hydrochloride, enalapril maleate, and captopril in tablets based on HPLC-PAD spectra

100%

Muhire J. , Li B. Q. , Zhai H. L. , Wang X. , Xu M. L.

Acta Chromatographica

2019

tom Vol. 31, no. 3

228--234

Diabetes mellitus and concurrent hypertension disorder are dreadful all over the world and are often managed by some drugs, such as metformin hydrochloride (MFH), enalapril maleate (ENM), and captopril (CAP). In this work, a reliable and fast quantitative analysis of these three components in tablets was carried out by Tchebichef image moment method and multivariate curve resolution with alternating least squares on three-dimensional (3D) spectra obtained by high-performance liquid chromatography coupled with photodiode array detection (HPLC-PAD). 3D spectra were obtained within only 2 min, and linear quantitative models were established by stepwise regression based on the calculated image moments. Among these two methods, Tchebichef image moment method showed outcome distinction. The correlation coefficients of cross-validation (RLoo-cv) are more than 0.988, while their recoveries are 100.1 ± 1.7% (MFH), 95.4 ± 5.4% (ENM), and 105.3 ± 5.7% (CAP), respectively. The intra- and inter-day precisions (RSD) are less than 5.42%. The proposed methods were also applied to the analysis of real tablets. This study reveals the effectiveness and convenience of the proposed image-moment method that may be a potential technology for the quality control and investigation of drugs in routine analysis.

Angiotensin converting enzyme inhibitors and atherosclerosis

100%

Andersson R. G. G. , Jacobsson L. , Persson K.

Journal of Physiology and Pharmacology

1994

tom 45

nr 1

Effect of captopril on potassium and magnesium concentration in blood plasma and erythrocytes of calves during the first week of life

84%

Ozgo M. , Skrzypczak W. F. , Kozok M.

nr 1

Orally administered angiotensin-converting enzyme-inhibitors captopril and isoleucine-proline-proline have distinct effects on local renin-angiotensin system and corticosterone synthesis in dextran sodium sulfate-induced colitis in mice

67%

Salmenkari H. , Holappa M. , Forsgard R. A. , Korpela R. , Vapaatalo H.

Journal of Physiology and Pharmacology

2017

tom 68

nr 3

Effect of ivabradine, captopril and melatonin on the behaviour of rats in L-nitro-arginine methyl ester-induced hypertension

67%

Aziriova S. , Repova K. , Krajcirovicova K. , Zorad S. , Mojto V. , Slavkovsky P. , Hodosy J. , Adamcova M. , Paulis L. , Simko F. , Baka T.

nr 6

Effect of converting enzyme inhibitor on copper and iron concentrations of blood plasma in calves during the neonatal period

67%

Skrzypczak W. , Dratwa-Chalupnik A. , Ozgo M. , Michalek K. , Lepczynski A. , Hejza K. , Siwa J.

Folia Biologica

2010

tom 58

nr 1-2

119-124

The antithrombotic effect of captopril and losartan on experimental arterial thrombosis in rats

67%

Chabielska E. , Pawlak R. , Golatowski J. , Buczko W.

Journal of Physiology and Pharmacology

1998

tom 49

nr 2

Antithrombotic effect of tissue and plasma type angiotensin converting enzyme inhibitors in experimental thrombosis in rats

67%

Wojewodzka-Zelazniakowicz M. , Chabielska E. , Mogielnicki A. , Kramkowski K. , Karp A. , Opadczuk A. , Domaniewski T. , Malinowska-Zaprzalka M. , Buczko W.

2006

tom 57

nr 2

This study compared the antihrombotic effect of plasma angiotensin converting enzyme inhibitors (ACE-Is): captopril (CAP), enalapril (ENA) and Tissue ACE-Is: perindopril (PER), quinapril (QUIN) in experimental venous and arterial thrombosis. Normotensive Wistar rats were treated p.o. with CAP (75 mg/kg), ENA (20 mg/kg), PER (2 mg/kg) and QUIN (3 mg/kg) for 10 days. The influence of ACE-Is on coagulation and fibrinolytic systems as well as platelet function was evaluated. The hypotensive effect of ACE-Is was equal in all groups. QUIN mantained the final carotid blood flow at the highest value in comparison to PER and plasma ACE-Is. The arterial thrombus weight was reduced in PER and QUIN groups while venous thrombus weight was also reduced after CAP. Tissue andplasma ACE-Is caused the inhibition of platelet adhesion and aggregation. A reduction of fibrin generation, prolongation of prothrombin time (PT), activated partial thromboplastin time (APTT) and shortening of euglobulin clot lysis time (ECLT) were observed after PER and QUIN treatment. In conclusion, given in equipotent hypotensive doses, Tissue ACE-Is exerted more pronounced antithrombotic effect than plasma ACE-Is in experimental thrombosis. The differences between Tissue and plasma ACE-Is in terms of their more pronounced inhibition of experimental thrombosis may be related to the intensified activation of fibrinolysis and inhibition of coagulation.