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3 Bulletin of the Veterinary Institute in Puławy

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Effects of dexamethasone on physical properties and mineral density of long bones in piglets

100%

Sliwa E. , Kowalik S. , Tatara M. R. , Majcher P. , Krupski W. , Studzinski T.

Bulletin of the Veterinary Institute in Puławy

2005

tom 49

nr 1

Effects of L-analyl-L-glutamine dipeptide administration during 35 days of postnatal life on intestinal mucosa bone properties, and performance of piglets in their early post-weaning period

84%

Pawlowska M. , Piedra J. L. V. , Filip R. , Szymanczyk S. E. , Kapica M. , Puzio I. , Skrzypek H. , Gawron A. , Pierzynowski S. G. , Studzinski T.

Bulletin of the Veterinary Institute in Puławy

2007

tom 51

nr 1

The experiment was performed on piglets, divided into control and experimental groups The experimental group received orally, from the birth to the 35th d of life, 0.4 g/kg b.w. /d of L-alanyl-L-glutamine dipeptide (Ala-Gln). One week after weaning the piglets were killed and the small intestine and bones were sampled for histological analyses. Measurements of bone physical and geometric properties were performed according to Ferreti method. The mineral density was analysed by the DEXA method. Ala-Gin treated piglets had a higher body weight at the 35 d of age compared to that of the control piglets. Mucosa thickness, villus length, and crypt depth in the jejunum of the piglets showed higher values compared to controls. In Ala-Gin treated piglets bone physical and geometric parameters and mineral density were significantly higher, and the bone structure revealed a shift in its organisation and mineralization process. In conclusion, oral administration of Ala-Gln protects the piglets from body weight loss and intestinal hypotrophy correlated with weaning and preserved the normal development of the femora during the post-weaning period.

Influence of intragastric administration of ghrelin receptor antagonist [D-Lys3]-ghrp-6 on bone tissue in rats

67%

Puzio I. , Piedra J. L. V. , Kapica M. , Bienko M.

Bulletin of the Veterinary Institute in Puławy

2011

tom 55

nr 3

The aim of the study was to investigate the influence of [D-Lys3]-growth hormone releasing peptide-6 (GHRP-6), an antagonist of GHS-R1a, on the growth performance and properties of bone tissue in rats. The studies were performed on 12 male Wistar rats, divided into two equal groups. Control rats received 0.5 ml of physiological saline, while experimental rats received intragastrically 100 nmol/kg b.w. of [D-Lys3]-GHRP-6 once a day, throughout 4 weeks. After that time, the animals were subjected to euthanasia. tBMC, tBMD, lean mass (LM), and fat mass (FM) contents were measured using DEXA methods. Plasma level of total ghrelin was also measured. The quality of the femur and tibia was estimated based on their weight, length, BMC, and BMD. [D- Lys3]-GHRP-6 decreased final body weight, LM content, and tBMD, and significantly reduced bone weight and BMC as compared to the control group. No significant differences were noted in bone length and BMD. Plasma level of total ghrelin was significantly higher after the treatment. We concluded that the intragastric treatment with [D-Lys3]-GHRP-6 negatively influenced the growth performance and properties of bone in rats. Therefore, ghrelin probably achieves effect in bone by acting on its specific receptor GHS-R1a.