Wyniki wyszukiwania - Biblioteka Nauki

1

Acute lead poisoning in an indoor firing range

100%

Štěpánek L. , Nakládalová M. , Klementa V. , Ferenčíková V.

Medycyna Pracy

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2020

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tom 71

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nr 3

375-379

EN

The presented case demonstrates that acute lead poisoning may occur due to just short-term exposure to a mixture of lead-containing dust and ammunition. Such exposure may result in high blood lead levels persisting for years in the absence of any symptoms. A middle-aged male with a history of an approximately 7-day cleanup of an old recreational firing range with large ammunition and dust deposits presented to an emergency department with abdominal pain, dyspnea, fatigue and impaired cognitive function. Given his occupational history, specific tests were performed that showed high lead concentrations in both blood and urine. The patient was diagnosed with acute lead poisoning. He was started on chelation therapy that improved both clinical and laboratory parameters. Over a subsequent nearly 3-year follow-up, the patient’s blood lead levels fluctuated and continued to be increased. Given the absence of other sources of lead exposure, these were likely due to the formation of bone deposits. Med Pr. 2020;71(3):375–9

2

Studies on battery repair and recycling workers occupationally exposed to lead in Karachi

84%

Haider M. J. , Qureshi N.

Roczniki Państwowego Zakładu Higieny

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2013

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tom 64

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nr 1

EN

Objective. The present study was carried out to investigate the effects of occupational lead exposure on the hematological and biochemical parameters in occupationally exposed and non exposed inhabitants of Karachi. Material and methods. In 100 lead exposed subjects recruited from automobile workshops, lead battery repair and recycling units located in Karachi and in 100 control subjects the general health status, hematological parameters and exposure markers for lead were measured. Results. Results indicated that the mean values of blood lead level and δ-aminolevulinic acid were significantly higher (P<0.05) while the activity of δ-aminolevulinic acid dehydratase were significantly decreased (P<0.05) among battery repair and recycling workers as compared to controls. The abnormalities in the blood lead level, δ-aminolevulinic acid and δ-aminolevulinic acid dehydratase were more frequent in lead exposed battery repair workers when compared with control subjects. The blood lead levels and δ-aminolevulinic acid were positively correlated while δ-aminolevulinic acid dehydratase was found to be negatively correlated with age, years of exposure and years of employment. Blood lead level was positively correlated with hemoglobin and RBC count while δ-aminolevulinic acid dehydratase was negatively correlated with hemoglobin concentration. The work related symptoms, droopiness, nasal symptoms and muscular pain were more frequent among battery repair workers as compared to control group. The findings of present study confirmed that occupational exposure to lead is associated with deviation in important hematological parameters and biological markers of exposure to lead among lead exposed workers, and also confirms the impact of lead exposure in the development of adverse effects among lead exposed workers. Conclusions. The study provides the data for risk assessment in lead battery repair workers of Karachi and suggests the need for preventive measures for battery repair workers and improvements to reduce occupational lead exposures to protect them from lead toxicity. It is suggested that hematological and physical examinations of lead exposed workers should be carried out periodically to prevent future health hazards.

PL

Cel. Badania przeprowadzono w celu określenia wpływu zawodowego narażenia na ołów na hematologiczne i biochemiczne parametry u zawodowo narażonych w porównaniu do nienarażonych mieszkańców Karaczi. Materiał i metody. U 100 osób narażanych na ołów spośród pracowników zatrudnionych w zakładach naprawy i przetwarzania akumulatorów w Karaczi i u 100 osób kontrolnych badano ogólny stan zdrowia, parametry hematologiczne i markery narażenia na ołów. Wyniki. Wyniki wskazują, że średnie poziomy ołowiu i kwasu δ-aminolewulinowego we krwi były znacząco wyższe (P<0.05), podczas gdy aktywność dehydratazy kwasu δ-aminolewulinowego była znacząco niższa (P<0.05) u zatrudnionych przy naprawie i przetwarzaniu akumulatorów w porównaniu do osób z grupy kontrolnej. Poziomy ołowiu we krwi i kwasu δ-aminolewulinowego były skorelowane pozytywnie podczas gdy w przypadku aktywności dehydratazy kwasu δ-aminolewulinowego stwierdzono negatywną korelację do wieku i mierzonego w latach czasu narażenia. Stężenie ołowiu we krwi było pozytywnie skorelowane z hemoglobiną i liczbą erytrocytów a aktywność dehydratazy kwasu δ-aminolewulinowego była negatywnie skorelowana ze stężeniem hemoglobiny. Objawy związane z wykonywaną pracą, takie jak osłabienie, objawy ze strony nosa i bóle mięśniowe częściej występowały u osób narażonych niż z grupy kontrolnej. Wyniki przeprowadzonych badań potwierdziły, że zawodowe narażenie na ołów wiąże się ze zmianami istotnych parametrów hematologicznych i występowaniem markerów narażenia na ołów u narażonych pracowników, a także występowaniem szkodliwych skutków zdrowotnych. Wnioski. Wyniki badań dostarczają danych do oceny ryzyka u pracowników naprawy i recyklingu akumulatorów i sugerują potrzebę zastosowania środków zaradczych w celu obniżenia zawodowego narażenia na ołów u tej grupy pracowników i ochrony przed toksycznym oddziaływaniem ołowiu. Sugeruje się, że badania parametrów hematologicznych i medycznych u pracowników narażonych na ołów powinny być wykonywane okresowo w celu zapobieżenia przyszłym zagrożeniom zdrowia.

3

Blood lead concentrations in children from industrial areas in Southwestern Poland in 1995 and 2007

84%

Ignasiak Z. , Slawinska T. , Malina R. , Little B.

Polish Journal of Environmental Studies

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2011

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tom 20

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nr 2

EN

The Legnica-Głogow Copper Mining District has been the site of metal mining for more than 50 years. Intensive environmental actions have, more recently, been aimed at reducing emissions of harmful substances in the region. We compared the blood lead concentrations of children resident in the copper smelting district in southwestern Poland in 1995 and 2007. The sample included 1,405 children, 7-15 years of age, resident in the same communities in the Legnica-Głogow Copper Mining District in 1995 (432 boys, 403 girls) and 2007 (279 boys, 291 girls). Blood samples were drawn (venipuncture) and analyzed for lead levels (Pb-B) with the same protocol in both years (atomic absorption spectrometry in a graphite furnace). Analysis of covariance, with age and age squared as covariates, was used to compare blood lead levels between years, regions (Głogow and Legnica), and genders. The prevalence of children with blood lead levels >6 μg/dl was compared between years, regions, and genders, and was compared with the chi square statistic (χ²). Blood lead level was significantly higher in 1995 (7.52±0.12 μg/dL) compared to 2007 (4.80±0.16 μg/dL), a decline of 2.72±0.19 μg/dL over the 12-year interval. Blood lead levels were higher in boys than in girls in each year, and declined between 1995 and 2007 in each gender, 8.61±0.16 μg/dL and 5.31±0.23 μg/dL, respectively, in boys, and 6.43±0.17 μg/dL and 4.29±0.22 μg/dL, respectively, in girls. Percentages of high blood lead levels (>6 μg/dL) were significantly higher in boys than girls in both years (1995: 77.5% and 51.9%, respectively; 2007: 32.6% and 16.5%, respectively), and declined significantly between 1995 and 2007 in both genders. Blood lead levels decreased over the interval of 12 years in school children resident in the Legnica-Głogow Copper Mining District.