Wyniki wyszukiwania - Biblioteka Nauki

1

Modelling of the pathological bile flow in the duct with a calculus

100%

Kuchumov A. G. , Nyashin Y. I. , Samarcev V. A. , Gavrilov V. A.

Acta of Bioengineering and Biomechanics

|

2013

|

tom Vol. 15, no. 4

9--17

EN

The aim of the present paper is to develop an analytical model for description of the pathological bile flow in the major duodenal papilla duct with a calculus. The problem is separated into two parts. The first part deals with determination of bile behaviour and constitutive relation parameters of the pathological bile. The viscosity vs. shear rate, the viscosity vs. time, and shear stress vs. shear rate dependences are obtained for different types of bile taken from patients of different age and sex. As a result, the approximation of curves described by the Casson equation was obtained. It was shown that the pathological bile is a thixotropic non-Newtonian fluid. The second part is directly related to modelling of the bile flow in the duct with a calculus. As a result of solving the problem, the bile velocity profile, flow rate vs. time, and bile pressure vs. calculus radius were obtained. The dependences obtained may play an important role in the assessment of an indication to operation.

2

The role of reduced glutathione in bile formation in sheep

100%

Bobowiec R. , Kosior-Korzecka U. , Martelli F. , Sighieri C.

Polish Journal of Veterinary Sciences

|

1999

|

tom 02

|

nr 1

EN

The present study reports the investigation on the influence of reduced glutathione (GSH) on bile secretion in 4 canulated sheep during constant intraduodenal infusion of bile alone, bile with sodium taurocholate (TCHNa) or bile with sodium deoxycholate (DCHNa). Infusions of bile alone and bile with TCHNa or DCHNa brought about an increase in the bile salts secretion from 0.05 ± 0.01 (μM/min/kg to the value of 0.12 ± 0.03, 0.22 ± 0.07 and 0.32 ± 0.08 μM/min/kg, respectively. It was shown that the administration of GSH during the infusion of both bile alone and bile+bile salts slightly but significantly (p < 0.05) lowered bile salts secretion. At the same time both bile with glutathione and bile+bile salts+glutathione increased the bile flow significantly (p < 0.05) as compared to that found after infusions without glutathione. After the i.v. administration of GSH, the volume of the bile increased to a lesser extent than it did with bile+TCHNa or, especially, with bi- le+DCHNa infusions. The concentration of glutathione in the bile was the highest during the infusion of bile+DCHNa (671.18 ng/ml), lower during the infusion of bile+TCHNa (471.40 ng/ml) and the lowest during the infusion of bile alone. Although the bile salts secretion decreased during the simultaneous infusion of the bile with bile salts and glutathione, there was an increase in the bile flow. Therefore, we concluded that some bile acid independent fraction was secreted into the bile and that the fraction was dependent on GSH secretion at the level of canaliculi.

3

Effects of sodium taurocholate and sodium dehydrocholate on bile flow, lipid and bilirubin secretion in sheep

84%

Bobowiec R. , Studzinski T. , Sikorska M.

Acta Physiologica Polonica

|

1990

|

tom 41

|

nr 7

EN

Bobowiec R., Studziński T. and Sikorska M.: Effects of sodium taurocholate and sodium deyhdrocholate on bile flow and lipid and bilirubin secretion in sheep. Acta Physiol. Pol. The investigation was performed on 8 sheep with implanted catheters in the common bile duct and in the cystic duct. Sodium taurocholate and sodium dehydrocholate were infused into the jugular vein at the rate of 50 µmol/min for 20 min. Directly after the termination of the sodium taurocholate infusion, the volume of the secreted bile increased from 8.4-9 µl· kg⁻¹ · min⁻¹ to the highest mean value of 17.8 µl·kg⁻¹ , min⁻¹ , with a simultaneous increase in the concentration of cholates from 1.71 mmol/1 to 4.82 mmol/1 and bilirubin from 271.1 µmol/1 to 461.7 µmol/1. The concentration of cholesterol and phospholipids in the bile also increased, but did not reach statistically significant values. The infusion of sodium dehydrocholate caused an increase in the bile secretion to the highest mean value of 20.59 µ1 · kg⁻¹ · min⁻¹ with a simultaneous decrease in the concentration of bilirubin to 148.75 µmol/1, cholesterol to 233.0 µg/ml, phospholipids to 56.11 µg/ml and cholate to 1.0 mmol/1. The results show that biliary secretion of phospholipids, cholesterol and bilirubin is dependend on the secretion of sodium taurocholate rather than on dehydrocholic acid.

4

The influence of gastrointestinal hormone infusion upon the change of lithogenic index value in the rat

84%

Romanski K. W. , Bochenek W. J.

Polish Journal of Veterinary Sciences

|

1998

|

tom 01

|

nr 1

EN

Rats, after cannulation of the common bile duct, duodenum and vena cava posterior were infused i.d. with sodium taurocholate to partially maintain the enterohepatic circulation of bile acids. Four-h i.V. infusions of glucagon, Boots secretin, Boots CCK and OP-CCK were continued together with bile acid administration. The bile was collected throughout the experiment and the bile volume, bile acid, phospholipid and cholesterol content in bile were determined. From these results molar lipid per cent and the lithogenic index were computed. During glucagon administration the lithogenic index was enhanced and molar per cent of phospholipids and cholesterol was greater, and that of bile acids was lower, than in rats deprived of hormone infusion. The effect of secretin upon the lithogenic index and the proportion of lipids was similar, although the rate of bile acid secreted was almost twice as high than that during glucagon infusion. When CCK was infused, despite enhanced per cent of bile acids, the lithogenic index was also higher than in the control group. No significant changes in both molar lipid composition and the lithogenic index were obtained when OP-CCK was applied. It is proposed that gastrointestinal hormones can affect bile lithogenicity through alterations of biliary lipid secretion.