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Budowa i rola DBP [Vitamin D-Binding Protein] w stanach fizjologii i patologii u zwierzat i ludzi

100%

Madej J. P. , Boratynski J. , Nowacki W.

tom 62

nr 09

987-991

The vitamin D-binding protein (DBP), also known as group-specific component or Gc globulin, demonstrates a pleiotropic effect in human and animal bodies. DBP binds vitamin D and its derivatives. It plays a key role in the extracellular actin-scavenger system (EASS) through the ability of actin binding. DBP is a precursor of the macrophage-activating factor in the inflammation-primed macrophage activation cascade. It binds various cells to the surface of and can significantly enhance the leukocyte chemotactic activity for C5a and C5a des Arg. Anti-human DBP serum shows a cross-reactivity with the serum of the various species in double immunodiffusion or immunoelectrophoresis tests. The polymorphism of DBP in humans and animals indicates a species-characteristic pattern in PAGE and IEF. Gc globulin may be used as a non-specific marker of diseases and some clinical states of patients.

Oznaczanie testem ELISA poziomu DBP w surowicy klaczy po porodzie

84%

Madej J. P. , Borkowski J. , Boratynski J. , Nowacki W.

nr 05

707-712

The vitamin D-binding protein (DBP), also known as Gc-globulin, plays a role as vitamin D and its metabolites carrier; actin scavenger, a precursor of macrophage activating factor (DBP-MAF), binds fatty acids located on the surface of many cell types and enhances chemotactic activity of C5 and C5a des Arg. In the authors’ studies, in order to assess DBP level in mares sera, the ELISA test was developed and standardized. The aim of this study was likewise to compare the level of Gc protein in sera of mares after delivery as compared to non-pregnant mares. The sera derived from 77 full blood mother-mares taken at 36-48 h after delivery, sera of 6 mares that had not taken part in reproduction and sera of 3 geldings the Wielkopolska breed. The authors demonstrated that two days after delivery the DBP concentration in mother-mares sera was significantly higher (p = 0.001291 < α = 0.05) than in non-pregnant mares. It was also proved that DBP level in mother-mares sera had no relation to age or number of deliveries.

Relationship between the genetic polymorphism of blood proteins and the coat colour in horses

67%

Pikula R. , Tomaszewska-Guszkiewicz K. , Smugala M. , Stepien J.

Animal Science Papers and Reports

1997

tom 15

nr 1

15-22

The use of blood protein polymorphism for determining the genetic distance between half-bred stallions

67%

Pikula R. , Tomaszewska-Guszkiewicz K. , Smugala M. , Stepien J.

Animal Science Papers and Reports

1997

tom 15

nr 1

5-14