Wyniki wyszukiwania - Biblioteka Nauki

Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

Ograniczanie wyników

Znaleziono wyników: 3

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: beta-2-microglobulin

Sortuj według:

Ogranicz wyniki do:

Changes in haematological parameters and serum beta-2-microglobulin levels in CD4+ T-cells-stratified Nigerian HIV patients

100%

John Ayodele Olaniyi J. A. , Godwin Joseph Emeka G. J. , Abdulfatah Adekunle Onifade A. A. , Alaruru Olusoji Adeyanju A. O. , Sheu Kadiri Rahamon S. K.

nr 1

33-39

Introduction. Reports have shown that there is a rise in beta-2-microglobulin (β2M) concentration in patients with HIV infection and that the degree of elevation correlates well with the extent of disease burden and could be an independent prognostic marker for death. However, there is the dearth of information on the interplay between alteration in haematological profile, a common cause of morbidity and mortality in HIV, and β2M. Aim. Changes in selected haematological parameters and β2M in Nigerian HIV patients stratified based on CD4+ T-cells counts were thus assessed in this study. Material and methods. Forty-eight asymptomatic, drug naïve HIV patients were enrolled into this cross-sectional study. Haemoglobin concentration (Hb), packed cell volume (PCV), total and differential white blood cell count, platelet count and CD4+ T-cells count were determined using standard methods while serum levels of β2M were determined using ELISA. Thereafter, the patients were stratified into three groups based on the CD4+ T-cells count. Results. Hb and lymphocyte counts increased with increasing CD4+ T-cells count. In contrast, neutrophils percentage, MCV and MCH reduced with increasing CD4+ T-cells count. The mean lymphocytes percentage was significantly higher while the mean neutrophils percentage was significantly lower in patients with CD4+ T-cells count of 500–800 cells/μl compared with the patients with CD4+ T-cells count <200 cells/μl. Similarly, the mean MCV was significantly lower in patients with CD4+ T-cells count of 500–800 cells/μl compared with patients with CD4+ T-cells count of 200–499 cells/μl and patients with CD4+ T-cells count <200 cells/μl. β2M had significant positive correlation with WBC and neutrophils percentage but had a significant negative correlation with lymphocytes percentage and MCH in patients with CD4+ T-cells count <200 cells/μl. However, β2M had sig nificant positive correlation with PCV, Hb, monocytes and morphology in patients with CD4+ T-cells count of 500–800 cells/μl. Conclusion. It could be concluded from this study that HIV infection is associated with alteration in haematological profile and the alteration is CD4+ T-cells count-dependent. Also, elevation in β2M concentration appears to be a marker of lymphopaenia in patients with low CD4+ T-cells count

Beta-2-microglobulin and neopterin in patients with giardiasis

86%

Czarnowski D. , Miegoc H. , Kalinowska A. , Prokopowicz D.

nr 3

The influence of chelidonine and Ukrain on the beta-2-microglobulin concentration in the serum of lead-poisoned rats

72%

Jagiello-Wojtowicz E. , Maciejewska-Kozak H. , Chodkowska A. , Radej R.

nr 3-4

The present study investigated the effects of single (lx) administration and a 10-day treatment with chelidonine (50 and 100 mg/kg i.p.) or drug Ukrain (7 and 14 mg/kg i.p.) on the ß2-microglobulin concentration in the serum of acute or subacute lead-poisoned rats (30 mg/kg i.p.). Both acute and subacute lead-intoxication significantly enhanced ß2- microglobulin concentration in the rats serum in comparison to the control groups. In acute poisoning only chelidonine (100 mg/kg i.p.) significantly decreased ß2-microgIo- bulin concentration in the rat serum. In subacute lead intoxication, 10-day treatment with chelidonine (50 mg/kg i.p.) or Ukrain (14 mg/kg i.p.) significantly decreased ß2- microglobulin in the serum of rats. Both chelidonine as well as Ukrain decreased nefrotoxicity induced by lead acetate. These investigations are to be continued.

W pracy badano wpływ jednorazowego i 10-dniowego podawania chelidoniny (50 i 100 mg/kg i.p.) oraz leku Ukrain (7 i 14 mg/kg i.p.) na stężenie ß2-mikroglobuliny w surowicy krwi szczurów w ostrym i podostrym zatruciu octanem ołowiu (30 mg/kg i.p.) Zarówno ostre, jak i podostre zatrucie ołowiem, powodowało istotny wzrost stężenia ß2-mikro- globuliny w surowicy szczurów w porównaniu z grupą kontrolną. U szczurów poddanych ostremu zatruciu ołowiem tylko chelidonina (100 mg/kg i.p.) istotnie obniżała stężenie P2-mikroglobuliny w surowicy krwi. 10-dniowe podanie chelidoniny (50 mg/kg i.p.) lub leku Ukrain (14 mg/kg i.p.) istotnie zmniejszało stężenie ß2-mikroglobuliny w surowicy zwierząt poddanych podostremu zatruciu ołowiem. Zarówno chelidonina, jak też lek Ukrain, zmniejszały nefrotoksyczność indukowaną ołowiem. Badania będą kontynuowane.