The intramolecular cyclization of 2-(2-formylphenoxy)hexanoic acid (FPHA) to 2-butylbenzofuran under the Perkin reaction conditions has been investigated. The influence of important parameters on the 2-butylbenzofuran yield in relation to 2-(2-formylphenoxy)hexanoic acid introduced (response function) has been described by regression equations in the form of a second order polynomial. The optimum values of: acetic anhydride to FPHA molar ratio, reaction time, acetic acid to FPHA molar ratio have been determined. 2-Butylbenzofuran and some of benzene-ring-halogenated 2-alkylbenzofurans have been obtained in moderate yields from corresponding 2-(2-formylphenoxy)alkanoic acids with the use of optimal conditions.