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A model of axonal transport drug delivery

100%

Kuznetsov A.

tom 10

nr 2

320-328

In this paper a model of targeted drug delivery by means of active (motor-driven) axonal transport is developed. The model is motivated by recent experimental research by Filler et al. (A.G. Filler, G.T. Whiteside, M. Bacon, M. Frederickson, F.A. Howe, M.D. Rabinowitz, A.J. Sokoloff, T.W. Deacon, C. Abell, R. Munglani, J.R. Griffiths, B.A. Bell, A.M.L. Lever, Tri-partite complex for axonal transport drug delivery achieves pharmacological effect, Bmc Neuroscience 11 (2010) 8) that reported synthesis and pharmacological efficiency tests of a tri-partite complex designed for axonal transport drug delivery. The developed model accounts for two populations of pharmaceutical agent complexes (PACs): PACs that are transported retrogradely by dynein motors and PACs that are accumulated in the axon at the Nodes of Ranvier. The transitions between these two populations of PACs are described by first-order reactions. An analytical solution of the coupled system of transient equations describing conservations of these two populations of PACs is obtained by using Laplace transform. Numerical results for various combinations of parameter values are presented and their physical significance is discussed.

Projections from the visual areas to the neostriatum in rats. A re-examination

86%

Lopez-Figueroa M. O. , Ramirez-Gonzalez J. A. , Divac I.

nr 3

Neurons of the claustrum projecting to the motor and somatosensory cortex in the rabbit - assessment with the method of retrograde transport of fluorescent tracers

86%

Kowianski P. , Morys J. , Dziewiatkowski J. , Karwacki Z. , Bobek-Billewicz B. , Narkiewicz O.

nr 4

Axonal accumulation of p75NTR and TrkA in the septum following lesion of septo-hippocampal pathways

72%

Skup M. , Bacia A. , Koczyk D. , Jeglinski W. , Zaremba M. , Oderfeld-Nowak B.

nr 2