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tom nr 3
22--36
EN
Among the tested methods of valorisation for recreation the analysis in terms of usefulness for recreational investment or attractiveness of recreation play a leading role (they relate to areas of highest natural values). There are many partial methods for assessing the usefulness of areas for recreation (or tourism) dependent on spatial scale, degree of assessment generalization and professional orientation of the author. For urban areas or regions the role of the diversity of the geographical environment and communication accessibility of the area (the planning and spatial aspect,) stands out in the foreground. In studies on a local scale assessments of the resilience and health properties of the natural environment (the physiographic or phytosociological aspect) or following the needs of the people (the social aspect) are becoming more important. The new issue is a orientation of the conservational valorisation methods on determining of the recreation suitability of the cultural landscape of cities. The proper assessment of the recreation usefulness of historical areas needs by author to develop an indirect method, in which the analysis of the individual components of the geographical environment would impose usage patterns, taking into account the investment and spatial availability of areas, and natural and cultural values as elements of co-creating a harmonious landscape. Also the economic factors affecting the value of the land, and so far included occasionally have been subjected to a more detailed evaluation. The developed method of assessing the recreation usefulness of complex structures of the cultural landscape was based on the analysis of fortification works, preserved in the spatial structure of Warsaw. The method is based on the selected subgroups of criteria: primary- determining the recreation functions (the possibility of the introduction of recreational functions); secondary - determining the type of recreation. The primary criteria determine the current investment availability of areas and depend mainly on the way of development and use, ownership structure and purpose in the planning records. The secondary criteria determine the values of the area in terms of program and type of recreational behaviors.
EN
Changes in the large neutral amino acid (LNAA) transport across the blood-brain barrier (BBB) is thought to contribute to brain dysfunction in a number of clinical conditions, including phenylketonuria, acute liver failure, and sepsis. Here, we present a novel approach for estimating BBB permeability and the LNAA concentrations in brain extracellular fluid, by demonstrating that they can be mathematically derived on the basis of kinetic constants of the BBB available from the literature, if cerebral blood flow and the arterial and jugular venous LNAA concentrations are known. While it is well known that the permeability surface area product of the BBB to a LNAA from blood to brain (PS1) can be calculated from the arterial LNAA concentrations and kinetic constants of the BBB, we demonstrate that the permeability surface area product from brain to blood (PS2) can be calculated by deriving the substrate activity of the saturable transporter from the kinetic constants and arterial and jugular venous LNAA concentrations, and that the concentration of the LNAA in brain extracellular fluid can then be determined. This approach is methodically simple, and may be useful for assessing the transcerebral exchange kinetics of LNAAs in future human-experimental and clinical studies.
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