Wyniki wyszukiwania - Biblioteka Nauki

1

Study of the arterial blood supply of the pancreas harvested for transplantation

100%

Fiedor P. , Rezulski J. , Wierzbicki Z. , Danielewicz R. , Michalak G. , Walaszewski J. , Nowak M. , Rowinski W.

|

1989

|

tom 48

|

nr 1-4

2

Ventilatory response to hypoxia in experimental pathology of the diaphragm

63%

Sokolowska B. , Jozwik A.

|

nr 3

121-126

EN

In this study, we examined the usefulness of arterial blood gas variables, as changed by the hypoxic stimulus, in discerning various experimentally-induced conditions of diaphragm weakness in anesthetized cats. We defined three experimental situations (models): (i) intact muscle, statistical Class I, (ii) four degrees of muscle dysfunction (after sequential diaphragm denervation), Classes II-V, and (iii) entirely paralyzed muscle, Class VI. Responses to a hypoxic stimulus in the above-mentioned conditions were evaluated by using the methods of the pattern recognition theory. We found that before the hypoxic stimulus, with partial but of different severity denervation of the diaphragm, the k-nearest neighbor classifier (k-NN) assigned 100% of the classified cases to Class II (one phrenic nerve rootlet cut). In contrast, during hypoxia only 67% of cases were assigned to Class II, the remaining being spread throughout other classes of muscle weakness. When one limits the procedure to the extreme classes: Class I (intact diaphragm) and Class VI (totally denervated diaphragm), the k-NN picks out 33% and 50% cases of bilateral diaphragm paralysis before and during hypoxia, respectively. We conclude that any remaining innervations of the diaphragm ensure the functionally optimal level of lung ventilation that may waver when hypoxia develops.

3

Haematological and biochemical blood parameters and acid-base balance parameters of the arteliar blood of free-living and caged European brown hares (Lepus europeaus)

63%

Nicpon J. , Slawuta P. , Noszczyk-Nowak A.

Bulletin of the Veterinary Institute in Puławy

|

2010

|

tom 54

|

nr 4

EN

The comparative study was performed on 200 European brown hares. Group I consisted of 35 clinically healthy hares kept in cages. Group II comprised 165 clinically healthy hares caught alive in their natural environment. Following the premedication, arterial and venous blood was drawn from the hares of the two groups studied. In the arterial blood, the acid-base balance (ABB) parameters were determined - blood pH, pCO₂, t CO₂, HCO₃⁻, BB, and BE. In the venous blood, the activity of AST, ALT, and FA, concentration of urea, creatinine, total protein, albumins, globulins, cholesterol, triglycerides, glucose, WBC, RBC, Hb, and Ht were determined. In addition, concentrations of Ca²⁺, P, Mg²⁺, Na⁺, K⁺, and Cl⁻ were measured in the blood serum. It was demonstrated that only the contents of globulins and triglycerides were similar in groups I and II. Concentration of electrolytes and ABB parameters were close to each other in the two studied groups, except for concentration of Mg²⁺ and inorganic P, and CO₂ molecular pressure. In the light of the obtained results a question remains opened: whether successful breeding, understood as an increase in the number of offspring of the reintroduced individuals, is more likely to occur in the case of animals caught alive and, adapted to living in their natural environment, or in the case of caged animals.

4

Acid-base indicators in the venous and arterial blood of horses affected by recurrent airway obstruction (RAO)

63%

Stopyra A. , Sobiech P. , Waclawska-Matyjasik A.

Polish Journal of Veterinary Sciences

|

2012

|

tom 15

|

nr 3

EN

The acid-base equilibrium is closely linked to gas exchange in the lungs, and respiratory exchange ratios are used to evaluate respiratory effectiveness and tissue oxygen levels. Acid-base indicators are determined in both arterial and venous blood samples. This study compares the usefulness of acid-base indicators of venous and arterial blood in monitoring the condition of horses with recurrent airway obstruction. Prior to treatment involving bronchodilating glucocorticoids, expectorant and mucolytic drugs, more pronounced changes were observed in venous blood (pH 7.283, pCO2 61.92 mmHg, pO2 35.541 mmHg, HCO3 - 31.933 mmHg, BE 2.933 mmol/l, O2SAT 58.366%, ctCO2 38.333 mmol/l) than in arterial blood (pH 7.309, pCO2 53.478 mmHg, pO2 90.856 mmHg, HCO3 - 28.50 mmHg, BE 3.133 mmol/l, O2SAT 93.375%, ctCO2 31.652 mmol/l), indicating compensated respiratory acidosis. The improvement of respiratory efficiency minimized acidosis symptoms in both venous blood (pH 7.365, pCO2 43.55 mmHg, pO2 47.80 mmHg, HCO3 - 30.325 mmHg, BE 3.050 mmol/l, O2SAT 80.10%, ctCO2 29.80 mmol/l) and arterial blood (pH 7.375, pCO2 39.268 mmHg, pO2 98.476 mmHg, HCO3 - 26.651 mmHg, BE 4.956 mmol/l, O2SAT 98.475%, ctCO2 28.131 mmol/l). Venous blood parameters were marked by greater deviations from mean values, both before and after treatment. Acid-base indicators determined in venous blood are indicative of respiratory disturbances, but they do not support a comprehensive evaluation of gas exchange in the lungs.

5

Influence of liver`s oxide-reductive homeostasis disorder for AKBR values in rabbit`s arterial blood

63%

Wardas M. , Aleksiewicz R. , Pawlowska-Goral K. , Adamiak Z. , Kostrzewski M. , Sierocinski M.

|

tom 10

|

nr 1

EN

The keton bodies are created generally in a liver, but this organ has no enzymatic system able to metabolize them. A dependence exists between the molar acetoacetate concentration and the molar ß-hydroxybutyrate concentration, and it can be an indicator of quantitive relations between NAD and NADH. Metabolic reserve can be estimated on the basis of the molar concentration of keton bodies in the arterial blood - of the AKBR value. Tests were carried out on specially prepared rabbit arterial blood samples. Because there is no way to measure NAD to NADH cocentrations in the liver directly a relationship between acetoacetate and ß-hydroxybutarate serves to estimate of the oxydo-reductive status of this key organ. That is why AKBR values seem to be extremely important. Vitamin E is known for it's cytoprotective influence of hepatic cells damage. In the presented paper we've challenged this hypothesis by analysing of correlation between AKBR values in examined rabbit group.

6

Thrombolysis by thienopyridines and their congeners

63%

Gryglewski R. J. , Dupin J. P. , Uracz W. , Swies J. , Madej J. , Hou G. , Gravier D. , Casadebaig F.

|

2000

|

tom 51

|

nr 4,1

7

Arterial ketone index in assessing liver function and its detoxicative capability after ischemia-reperfusion injury

63%

Caban A. , Wiaderkiewicz R. , Kaminski M. , Oczkowicz G. , Ziaja J.

|

2000

|

tom 47

|

nr 4

EN

Arterial ketone index (AKBR) which is the ratio of acetoacetic acid to 3-hydroxybutyric acid in the arterial blood, is believed to reflect the mitochondrial reduction potential of hepatocytes and general energy state of the liver. In the presented paper we challenged this hypothesis by analysing the correlation between AKBR and the results of typical liver blood tests (AspAT, AlAT, LDH, CRP) and biotransforming potential of the liver (cytochromes P450, b5 and their corresponding NADPH and NADH reductases) in the model of ischemia-reperfusion injury of rat liver. The results were compared with histochemical analysis of distribution and activity of SDH, LDH and G-6-Pase, the key marker enzymes of the liver. We have shown that, except in the case of acute phase protein (CRP), a decrease in AKBR correlated well with the increase of the level of indicator enzymes in serum. Histochemical analysis also confirmed that AKBR correlates with the degree of damage to hepatocytes during early stage of reperfusion after 60 min of liver ischemia. In the Spearman test, AKBR was significantly correlated with the changes in cytochrome P450 content and its NADPH reductase activity which indicates a high sensitivity of this test. We conclude that the decrease of AKBR value reflects the impairment of basic energy pathways and detoxicative capability of the liver.

8

Retrograde transfer of 125I-radiolabelled activin and inhibin in the periovarian vascular complex in the sow

51%

Wasowska B. , Stefanczyk-Krzymowska S. , Grzegorzewski W.

|

nr 2

159-167

EN

This study investigated whether activin A and an inhibin-a subunit fragment (INHα) could permeate in a periovarian vascular complex from ovarian effluent into the ovarian artery and be retrograde transferred into the ovary. Radiolabelled activin A (125I-activin A) and INHα (125I-INHα) were injected (2.7xl07 dpm) into follicles or corpora lutea (CL). It was demonstrated that 125I-activin A and 125I-INHa were released into the ovarian effluent and permeated into the arterial blood supplying the ovary in both phases of the cycle. The concentration of 125I-activin A in ovarian arterial blood was higher in the luteal phase (LP) than in the follicular phase (FP) (P<0.0001) in contrast to 125I-INHα which was higher in the FP (P<0.0001). The concentration of 125I-activin A in uterine tissues generally did not differ between the phases of the estrous cycle, but the concentration of 125I-INHα was higher (P<0.05) in the FP than in the LP. The concentration of 125I-activin A was higher in the LP in samples of endometrium and myometrium (P<0.05), as well as mesometrium (P<0.01), and higher in the FP in samples of mesometrium (P<0.05) close to the ovary than in the samples adjoining the uterine body. In the FP, the concentration of 125I-INHa was higher in endometrium and mesometrium close to the ovary than in samples adjoining the uterine body (P<0.05). In conclusion, the study demonstrated that it was possible for INHa and activin A to be retrograde transferred to the ovary. Thus this transfer could elevate their concentration in arterial blood supplied to the ovarian follicles or CL and may influence production of these peptides in the ovary, modulating ovarian function.

9

Aging and expression of heme oxygenase-1 and endothelin-1 in the rat carotid body after chronic hypoxia

51%

Di Giulio C. , Verratti V. , Artese L. , Petruccelli G. , Walski M. , Pokorski M.

Journal of Physiology and Pharmacology. Supplement

|

2009

|

tom 60

|

nr 5

10

The innervation and arterial blood supply of pig's stomach in foetal period

51%

Chroszcz A.

Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine

|

2008

|

tom 11

|

nr 3

11

Influence of the wing-of-the-nostrils correction procedure on the change of the acid-base balance parameters and oxygen concentration in the arterial blood in French bulldogs

51%

Slawuta P. , Nicpon J. , Domanska S.

|

nr 1

EN

Brachycephalic syndrome develops as a result of a specific build of splanchnocranium. In dogs of brachycephalic breeds, an impairment of correct gas exchange occurs. 5 French bulldogs at the age of 11-14 months, which suffered from continuous mixed-type dispnoea and lowered effort tolerance, were examined. Apart from the above-mentioned symptoms, the occurrence of strong external nostril stenosis was noted in the clinical examination. The symptoms observed together with the nostril stenosis indicated a possibility of an occurrence of the brachycephalic syndrome. 1 ml of full blood was drawn from the femoral artery. Acid-base balance parameters were determined in the arterial blood: pH, pCO₂, HCO₃ -, and pO₂. The wing-of-the-nostrils correction procedure were carried out in general anaesthesia. In premedication, the patients received medetomidine and after 15 minutes, fentanyl together with atropine. The induction of propofol was carried out. After four weeks from the procedure, blood was collected and the acid-base balance and pO₂ parameters were again determined. The obtained values of the acid-base balance and pO₂ parameters showed a noticeable influence of the wing-of-the-nostrils correction procedure on the values of the parameters determined. The results of the blood gasometry obtained prior to the procedure clearly indicate the occurrence of respiratory acidosis. The correction of wings of the nostrils significantly influenced saturation of the arterial blood with oxygen and the symptoms of dispnoea observed by the owners and episodes of apnoea and the loss of consciousness entirely subsided.

12

Acid-base balance parameters and ionic composition of arterial, venous and capillary blood in goats

51%

Sobiech P. , Pomianowski A. , Stopyra A. , Kuleta Z. , Zbanyszek M. , Procajlo A. , Rajski K.

Polish Journal of Veterinary Sciences

|

2004

|

tom 07

|

nr 2

13

Influence endothelin ET A receptor antagonist - BQ-123 - on changes of endothelin-1 level in plasma of rats with acute vasospasm following subarachnoid hemorrhage

51%

Josko J. , Hendryk S. , Jedrzejowska-Szypula H. , Gwozdz B. , Herman Z. S. , Gawlik R.

Journal of Physiology and Pharmacology

|

1998

|

tom 49

|

nr 3

14

The adrenal-renal vascular connection contributes to increase in renal vascular resistance during an experimental hypotension in the rat

51%

Ziecina R. , Abramczyk P. , Lisiecka A. , Przybylski J.

|

1997

|

tom 48

|

nr 2

15

Protein kinase C in the carotid body

51%

Pokorski M. , Faff L.

Acta Neurobiologiae Experimentalis

|

1999

|

tom 59

|

nr 2

16

Regional heterogeneity of myocardial blood flow within the rabbit left ventricle during haemorrhagic hypotension

51%

Standa M. , Iversen P. O. , Flatebo T. , Nicolaysen G.

Journal of Physiology and Pharmacology

|

1992

|

tom 43

|

nr 3

EN

Several studies have reported an extensive regional heterogeneity in myocardial blood flow. The reported coefficients of variation for regional myocardial perfusion range from about 0.2 to 0.4 in normotensive animals. The spatial distribution of myocardial perfusion during haemorrhagic hypotension seems not to have been assessed. The goal of the present study was to determine the regional heterogeneity in myocardial blood flow within the rabbit left ventricle during normal conditions and after haemorrhagic hypotension. Radioactive microspheres were infused into the left ventricle in barbiturate anaethetized rabbits over either 30 or 120 sec. The haemorrhagic hypotension was induced by bleeding, so that mean arterial blood pressure was reduced to about 50% of control. The left ventricles were divided into samples of about 0.025 g each. Regional heterogeneity in the blood flow was expressed as the coefficient of variation corrected for the Poisspn distribution of microspheres (CVc). The CVc was 0.37 ±0.09 (mean±SD) during control and 0.41+0.11 after bleeding, the CVc obtained after bleeding being somewhat higher than during control (P<0.05). We obtained a high correlation coefficient (τ about 0.68) between regional perfusion values at control and after bleeding which indicates a stable perfusion pattern within the myocardium. We conclude that the regional distribution of coronary blood flow within the left ventricle is markedly heterogenous during control condition and that this pattern is not changed during haemorrhagic hypotension.

17

Effect of unilateral ovariectomy on counter-current transfer of prostaglandin F2alpha in the area of mesometrium vasculature in the pig

44%

Stefanczyk-Krzymowska S. , Grzegorzewski W. , Skipor J. , Krzymowski T.

Bulletin of the Polish Academy of Sciences. Biological Sciences

|

1992

|

tom 40

|

nr 1

18

Przeciwpradowe przenikanie i zwrotny transport progesteronu, oksytocyny i prostaglandyny F2 alfa w obszarze wiezadla szerokiego macicy krow w czasie trwania fazy lutealnej

38%

Koziorowski M.

Acta Academiae Agriculturae ac Technicae Olstenensis. Veterinaria

|

1996

|

tom 22,Suppl.G

1-43

PL

W pracy przedstawiono wyniki badań własnych dotyczących przeciwprądowego przenikania z krwi żylnej i limfy do krwi tętniczej progesteronu, oksytocyny i prostaglandyny F2α w obszarze więzadła szerokiego macicy u krów będących w fazie lutealnej cyklu estralnego i na tym tle rozpatrzono znaczenie tego procesu w regulacji rozrodu u krowy. Progesteron wytwarzany przez ciałko żółte w czasie fazy lutealnej opuszcza jajnik z krwią żyły jajnikowej i limfą. W obszarze naczyń krezki jajnika (mesovarium) ulega przeciwprądowemu przenikaniu do krwi tętnicy jajnikowej. Powstaje zwiększona lokalna koncentracja progesteronu w tym obszarze, a przez gałąź maciczną tętnicy jajnikowej również w obszarze macicy i jajowodu. Sugeruje się, że tą drogą zwiększona lokalnie koncentracja progesteronu bierze udział w przygotowaniu macicy do spełnienia funkcji wydzielniczej, a szczególnie ma to znaczenie w sekrecji PGF2α. Wykazano również przeciwprądowe przenikanie i transport jajnikowej oksytocyny z krwi żylnej odpływającej z jajnika do krwi tętniczej zaopatrującej zarówno jajnik, jak i przez odgałęzienie tętnicy jajnikowej - macicę i jajowód. Sugeruje się, że lokalna koncentracja oksytocyny w obszarze macicy i jajowodu ma na celu zapoczątkowanie zmian, zarówno naczyniowych, jak i wydzielniczych, związanych ze zbliżającą się luteolizą. Wykazano przeciwprądowe, zwrotne przenikanie PGF2α z krwi żylnej do krwi tętniczej w obszarze krezki macicy (mesometrium), przy czym proces ten z większą intensywnością przebiegał po stronie ciałka żółtego. Proces ten ma za zadanie ochronę aktywnego ciałka żółtego przed luteolizą.

EN

The paper presents the results of own investigations concerning counter-current transfer of progesterone, oxytocin and prostaglandin F2α from venous blood and lymph to arterial blood in the area of broad ligament of uterus in the case of cows going through the luteal phase of estral cycle. The significance of the above-mentioned process in regulation of cow reproduction was examined. Progesterone produced by corpus luteum during the luteal phase leaves the ovary with ovarian vein blood and lymph. It is then subjected, in the area of mesovarium, to counter-current transfer to the blood of ovarian artery. It causes an increase in local concentration of progesterone both in this area and, through the uterine branch of ovarian artery, in those of uterus and oviduct. It may suggest that in this way the locally increased concentration of progesterone participates in the preparations of uterus to performing the function of secretion, it is especially important in the case of PGF2α secretion. It was also shown that counter-current transfer and transport of ovarian oxytocin from venous blood, flowing from the ovary, to arterial blood supplying both the ovary and, through the branch of ovarian artery, the uterus and oviduct, takes place as well. It seems that the local concentration of oxytocin in the area of uterus and oviduct is aimed at starting some changes in vasculature and secretion, connected with approaching luteolysis. Counter-current back transfer of PGF2α from venous to arterial blood in the area of mesometrium was also observed. However, this process was more intensive on the side ipsilateral to corpus luteum. It is aimed at protection of active corpus luteum against luteolysis.