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Isonucleosides : Synthesis and Biological Activity

100%

Walczak K.

Polish Journal of Chemistry

1999

tom Vol. 73, nr 10

1613-1629

Synthesis of isonucleosides, compounds with the heterocyclic base placed at nonanomeric position is discussed. Such derivatives are synthesized either by nucleophilic substitution of a leaving group by activated base or by construction of heterocyclic system at the amino group present at the sugar ring.

Antivirals - current trends in fighting influenza

75%

Krol E. , Rychlowska M. , Szewczyk B.

Acta Biochimica Polonica

2014

tom 61

nr 3

Crystal structures of some acyclonucleosides with antiviral activity and related compounds

75%

Birnbaum K. B.

Acta Biochimica Polonica

1996

tom 43

nr 1

The crystal structure of the acyclonucleoside, 9-[4-hydroxy-2-(hydroxymethyl)- butyljguanine (2HM-HBG), has been compared with related acyclonucleosides, and that of the acyclonucleotide, 9-1(1,3-dihydroxy-2-propoxy)methyl]guanine-3',5'-cyclic phosphate (DlIPG-cMP), also with its parent second messenger cGMP and cyclic monophosphate nucleotides. There is considerable conformational flexibility in the acyclic chain of these compounds with several conformations coexisting in the solid state. This flexibility together with the narrow range of the glycosidic torsion angles (from 69° to 94°, with an average of 83(3)° for 11 molecules when the aglycon is guanine, and from 92° to 108° with an average of 103(3)° for 4 molecules when the aglycon is adenine) may be essential for the antiviral activity of these compounds and their ability to act as substrates. The mechanism of antiviral activity of, 9-1(1,3-dihydro- xy-2-propoxy)methyllguanine-3',5'-cyclic phosphate is different from that of the acyclonucleosides, and is discussed in the light of it being a close structural analogue to the second messenger cGMP.

Therapeutical effect of modified adamantane copolymer compounds: Study of molecular mechanisms

63%

Rybalko S. , Nesterova N. , Diadiun S. , Danylenko G. , Danylenko V. , Guzhova S. , Maksimov Y. , Arkadiev V. , Ivans'ka N. , Maksymenok O. , Vrnycianu N. , Zhtrebtsova E. , Grygoreva T.

Acta Biochimica Polonica

2001

tom 48

nr 1

Copolymers of N-polyvinylpyrrolidone-acrylic acid (AB-1) and adamantane derivatives are known to possess marked antiviral activity in in vitro and in ovo models. Among the constructed preparations of AB-1 modified by adamantane derivatives some, especially AB-4 (modified by deitiforin), were found to show more extended antiviral activity and to inhibit markedly virus reproduction in susceptible permissive cell cultures and chicken embryos. In AB-4 treated cells and allantoic sacs, virus titers (influenza virus, herpes virus, and HIV) and virus antigen concentration were decreased. On the other hand, herpes virus-specific thymidine kinase and of DNA-polymerases isolated from Escherichia coli, Plectonema boryanum, and herpes virus type 1 infected murine brain tissue retained their activity after incubation with AB-4 or AB-2. The compounds investigated, in view of their effect on virus reproduction, are thought to be prospective as antiviral agents.

Viral and host-cell protein kinases: enticing antiviral targets

63%

Shugar D.

Cellular and Molecular Biology Letters

1998

tom 03

nr 3

The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents

63%

Naesens L. , Balzarini J. , De Clercq E.

Postępy Biochemii

1995

tom 41

nr 5