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EN
The ability of various cytokines to hamper tumor growth or to induce anti-tumor im­mune response has resulted in their study as antitumor agents in gene therapy ap­proaches. In this review we will concentrate on the costimulation of antitumor immune re­sponses using modification of various cell types by cytokine genes. Several strategies have emerged such as (i) modification of tumor cells with cytokine genes ex vivo (whole tumor cell vaccines), (ii) ex vivo modification of other cell types for cytokine gene delivery, (iii) delivery of cytokine genes into tumor microenvironment in vivo, (iv) modification of dendritic cells with cytokine genes ex vivo. Originally single cytokine genes were used. Subsequently, multiple cytokine genes were applied simul­taneously, or in combination with other factors such as chemokines, membrane bound co-stimulatory molecules, or tumor associated antigens. In this review we dis­cuss these strategies and their use in cancer treatment as well as the promises and lim­itations of cytokine based cancer gene therapy. Clinical trials, including our own expe­rience, employing the above strategies are discussed.
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