Wyniki wyszukiwania - Biblioteka Nauki

1

Nanoparticles for targeted delivery of anticancer agents

100%

Storm G. , Molema G. , Woodle M. , Metselaar B. , Schiffelers R.

Cellular and Molecular Biology Letters

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2005

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tom 10

|

nr Suppl.

2

Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin

75%

Michalska M. , Pajak W. , Kolodziejska J. , Lazarenkow A. , Nawrot-Modranka J.

Acta Biochimica Polonica

|

2008

|

tom 55

|

nr 3

613-617

EN

The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity

3

The X-ray structure and absolute configuration of the anticancer drug (plus)-4-ketocyclophosphamide

75%

Gdaniec M. , Adamiak D. A. , Misiura K.

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1989

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tom 36

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nr 3-4

4

Experimental antitumor activity and toxicity of the selected triazolo- and imidazoacridinones

75%

Kusnierczyk H. , Cholody W. M. , Paradziej-Lukowicz J. , Radzikowski C. , Konopa J.

Archivum Immunologiae et Therapiae Experimentalis

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1994

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tom 42

|

nr 5-6

5

Intranasal administration of perillyl alcohol activates peripheral and bronchus-associated immune system in vivo

63%

D’Alincourt Salazar M. , da Silva R. F. , Da Fonseca C. O. , Lagrota-Candido J. , Quirico-Santos T.

Archivum Immunologiae et Therapiae Experimentalis

|

2014

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tom 62

|

nr 1

6

Biological evaluation of mitoxantrone dihydrochloride synthesized by a new method. II. Comparison of Now 85/34 and novantrone (Lederle) acute toxicity and antitumor activity

63%

Matuszyk J. , Kusnierczyk H. , Radzikowski C.

|

tom 37

|

nr 1-2

7

Antimetastatic potentials of 8-aryl-2,6,7,8-tetrahydroimidazo [2,1-C] [1,2,4]triazine-3,4-diones

63%

Sztanke K. , Pasternak K. , Sztanke M. , Kandefer-Szerszen M.

Journal of Elementology

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2009

|

tom 14

|

nr 3 Suppl.

81-82

8

Two Gln187 mutants of human soluble APRIL inhibit proliferation of lung carcinoma A549 cells

63%

Dai S. , Zheng Y. , Chen B. , Gao M. , Zhang Y. , Zhang L. , Gong W. , He F.

Acta Biochimica Polonica

|

2009

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tom 56

|

nr 4

703-710

EN

Soluble APRIL (sAPRIL), the active form of a proliferation-inducing ligand (APRIL), is implicated in the proliferation of tumor cells. Suppressing APRIL function has been considered as a potential strategy for the therapy of APRIL-associated tumors. In the present study, we generated human sAPRIL and its two mutants, Gln187-D-sAPRIL (Gln187 deleted) and Gly187-sAPRIL (Gln187 replaced by Gly). In vitro experiments showed that the two mutants had similar specific binding capacity to lung carcinoma A549 cells compared to the wild-type sAPRIL, and both, especially Gly187-sAPRIL, exhibited significant antagonistic effect on sAPRIL-induced tumor cell proliferation in a dose-dependent manner, which might be predominantly mediated by blocking sAPRIL-induced MEK and ERK phosphorylation but not p38MAPK or JNK signaling. In vivo experiments with nude mice bearing A549 cell-derived xenograft tumor showed that only the Gly187-sAPRIL mutant could significantly suppress the tumor growth. These results suggest that Gln187 may be a crucial amino acid in APRIL-mediated tumor cell proliferation via the MEK-ERK signaling pathway and that the sAPRIL mutants may serve as novel potential antagonists of APRIL for the therapy of APRIL-associated cancers.

9

Molecular modelling, synthesis and antitumour activity of carbocyclic analogues of netropsin and distamycin - new carriers of alkylating elements

63%

Bartulewicz D. , Markowska A. , Wolczynski S. , Dabrowska M. , Rozanski A.

|

2000

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tom 47

|

nr 1

EN

A series of netropsin and distamycin analogues was synthesised and investigated by molecular modelling. The lowest-energy conformations of four carbocyclic lexitropsins, potential carriers of alkylating elements, were obtained using the HyperChem 4.0 program, and compared with the DNA-lexitropsin crystal structures from the Brookhaven National Laboratory Protein Data Bank. A method for synthesis of carbocyclic lexitropsins was elaborated, with the use of a nitro group or azobenzene as precursors for the aromatic amino group. The influence of methoxy group in ortho position with respect to amide groups on the activity of the new compounds was investigated. All of the compounds tested showed high antitumour activity in the standard cell line of mammalian tumour MCF-7.

10

Comparative evaluation of toxicity and antitumor activity of original and reproduced anthracycline drugs

63%

Kusnierczyk H. , Radzikowski C. , Gorecki P. , Cichocka K.

Archivum Immunologiae et Therapiae Experimentalis

|

1994

|

tom 42

|

nr 1

11

Inhibition of tumor growth by interleukin 10 gene transfer in B16[F10] melanoma cells

63%

Walos S. , Szary J. , Szala S.

|

nr 4

EN

Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antitumor activity. The effect of IL-10 on tumor growth was tested in murine melanoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10 tumor growth was decreased depending on the amount of secreted IL-10.

12

Interferon caused alterations of human cell response to bleomycin in vitro

63%

Giannoylaki H. , Havredaki M.

|

tom 41

|

nr 5-6

13

Antitumour activity of Salmonella typhimurium VNP20047 in B16[F10] murine melanoma model

63%

Jazowiecka-Rakus J. , Szala S.

Acta Biochimica Polonica

|

2004

|

tom 51

|

nr 3

EN

A tumour therapy is proposed based on attenuated Salmonella typhimurium VNP20047 expressing the Escherichia coli cytosine deaminase gene. VNP20047 was administered intravenously to B16(F10) melanoma-bearing C57BL/6 mice. VNP20047 proliferated within tumours and livers regardless of the initial inoculum dose. After 10 days the number of bacteria increased in livers up to 4.2 x 106 cfu/g and decreased in tumours down to 5.9 x 106 cfu/g. VNP20047 at 1 x 105 cfu/mouse, when combined with 5-fluorocytosine, inhibited tumour growth by 85% without prolonging animal survival. Histology studies revealed severe lesions in tumours and livers. These data suggest that S. typhimurium VNP20047 induced inflammatory responses, even though the strain was attenuated.

14

Influence of mesna on urotoxic effects of selected bromosubstituted analogs of ifosfamide

63%

Kusnierczyk H. , Konarski L. , Kowalski P. , Radzikowski C.

|

nr 1

15

Peritonitis-induced antitumor activity of peritoneal macrophages from uremic patients

63%

Turyna B. , Jurek A. , Gotfryd K. , Siaskiewicz A. , Kubit P. , Klein A.

|

nr 3

16

Expression of antitumour response. Role of attachment and cytostatic effect of different substrains of Bacillus Calmette-Guerin to human bladder cancer cells

63%

Janaszek W. , Wysokinska T.

Bulletin of the Veterinary Institute in Puławy

|

1998

|

tom 42

|

nr 1

17

Acyclic analogues of 5-fluoro-dUMP and 5-fluoro-2'-deoxyuridine: Synthesis and inhibition of thymidylate synthase and tumour cell growth

63%

Felczak K. , Golos B. , Dzik J. , Rode W. , Bretner M. , Shugar D. , Kulikowski T.

|

nr 1

EN

1-[(2-Hydroxyethoxy)methyl]-5-fluorouracil (HEMFU) and 1-[(1,3-dihydroxy-2-propoxy)methyl]-5-fluorouracil (DHPFU) were prepared by alkylation of the di-O-TMS derivative of 5-fluorouracil and phosphorylated with the use of the wheat shoot phosphotransferase system to their monophosphates, HEMFUMP and DHPFUMP. 1-(2-Phosphonylmethoxyethyl)-5-fluorouracil (PMEFU) was obtained by condensation of diethyl-2-chloroethoxymethanephosphonate with 5-fluorouracil and cleavage of the alkylphosphoester with trimethylbromosilane. Inhibition of highly purified thymidylate synthase from mouse tumour Ehrlich carcinoma and leukemia L1210 cells by each of the nucleotide analogues, DHPFUMP, PMEFU and HEMFUMP, and of L5178Y mouse leukemia cell growth by the nucleoside (HEMFU) analogue, were studied. DHPFUMP proved to be the strongest inhibitor, non-competitive vs dUMP, with Kiapp 2.8 μM for time-independent interaction with the enzyme and N5,N10-methylenetetrahydrofolate (CH2H4PteGlu). In the presence of CH2H4PteGlu, DHPFUMP exhibited time-dependent inactivation of the enzyme, the inactivation rate plots being biphasic and pointing to Ki values in the μM range (103-fold higher than for 5-fluoro-dUMP). HEMFUMP and PMEFU were much weaker inhibitors of the enzyme, with Kiapp values of 0.26 μM (non-competitive vs dUMP) and 30 mM (non-competitive vs dUMP), respectively. HEMFU, despite the weak interaction of its nucleotide analogue with the enzyme, proved to be a strong cell (L5178Y) growth inhibitor, with IC50 in the range 10-5 M.

18

Cytokine regulation of monocyte recruitment

63%

Mantovani A. , Bottazzi B. , Sozzani S. , Peri G. , Allavena P. , Dong Q. G. , Vecchi A. , Colotta F.

Archivum Immunologiae et Therapiae Experimentalis

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1995

|

tom 43

|

nr 2

19

Biological evaluation of mitoxantrone dihydrochloride synthesized by a new method. I. Acute toxicity and antitumor activity in mouse transplantable tumor systems

51%

Matuszyk J. , Kusnierczyk H. , Radzikowski C.

|

tom 37

|

nr 1-2

20

Proliferation, differentiation and apoptosis of the choline deficient ethionine supplemented diet-rat oval cells under the influence of 2-methoxyestradiol

51%

Wojcik M. , Bobowiec R. , Lisiecka U. , Kostro K.

|

2012

|

tom 63

|

nr 6