Wyniki wyszukiwania - Biblioteka Nauki

1

Lipid peroxidation and antioxidant status in patients with periodontitis

100%

Panjamurthy K. , Manoharan S. , Ramachandran C. R.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr 2

2

Changes in antioxidant status of heart muscle tissue in experimental diabetes in rabbits.

88%

Gumieniczek A. , Hopkała H. , Wójtowicz Z. , Nikołajuk J.

Acta Biochimica Polonica

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2002

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tom 49

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nr 2

529-535

EN

The present study was designed to evaluate the oxidative stress-related parameters in alloxan-induced diabetes in rabbits. After 3, 6, 12 and 24 weeks of hyperglycaemia the enzymatic and non-enzymatic factors were measured in heart tissue of diabetic and control groups. Superoxide dismutase and glutathione peroxidase activities and the contents of total sulfhydryl compounds significantly increased at all time intervals. Catalase activity increased initially (after 3 and 6 weeks), decreased after 12 weeks and increased again at the 24th week of the experiment. Glutathione reductase activity increased initially (at 3rd week), decreased below control level after 6 and 12 weeks, then increased again. Ascorbic acid concentration decreased after 3 and 6 weeks, and increased at the 12th and 24th weeks. The level of lipid peroxidation products was reduced after 3, 6 and 12 weeks of the experiment. After 24 weeks it was significantly elevated. These data suggest that hyperglycaemia induces oxidative stress in the heart but the defense mechanisms in the heart tissue are fairly efficacious against oxidative injury.

3

Influence of non-enzymatic antioxidants on antioxidation status in acute haemorrhagic necrotizing pancreatitis in rat

88%

Marciniak A. , Lutnicki K. , Szpringer E. , Barham S.

Bulletin of the Veterinary Institute in Puławy

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2005

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tom 49

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nr 1

4

Deteriorations of pulmonary function, elevated carbon monoxide levels and increased oxidative stress amongst water-pipe smokers

75%

Yalcin F. K. , Er M. , Hasanoglu H. C. , Kilic H. , Senturk A. , Karalezli A. , Ergin M. , Erel O.

International Journal of Occupational Medicine and Environmental Health

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2017

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tom 30

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nr 5

731-742

EN

Objectives A water pipe (hookah) is a tobacco smoking tool which is thought to be more harmless than a cigarette, and there are no adequate studies about its hazards to health. Water-pipe smoking is threatening health of the youth in the world today. The objective of this study has been to investigate the carbon monoxide (CO) levels in breath, examine the changes in pulmonary function tests (PFT) and to assess the change of the oxidative stress parameters in blood after smoking a water pipe. Material and Methods This study is a cross-sectional analytical study that has included 50 volunteers who smoke a water pipe and the control group of 50 volunteers who smoke neither a cigarette nor a water pipe. Carbon monoxide levels were measured in the breath and pulmonary function tests (PFTs) were performed before and after smoking a water pipe. Blood samples were taken from either the volunteer control group or water-pipe smokers group after smoking a water pipe for the purpose of evaluation of the parameters of oxidative stress. Results Carbon monoxide values were measured to be 8.08±7.4 ppm and 28.08±16.5 ppm before and after smoking a water pipe, respectively. This increment was found statistically significant. There were also significant reductions in PFTs after smoking a water pipe. Total oxidative status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were found prominently higher after smoking a water pipe for the group of water-pipe smokers than for the control group. Conclusions This study has shown that water-pipe smoking leads to deterioration in pulmonary function and increases oxidative stress. To the best of our knowledge this study is the only one that has shown the effect of water-pipe smoking on oxidative stress. More studies must be planned to show the side effects of water-pipe habit and protective policies should be planned especially for young people in Europe. Int J Occup Med Environ Health 2017;30(5):731–742

5

Disturbances of anti-oxidative balance in rats caused by aflatoxin B1

75%

Wojtowicz-Chomicz K. , Stadnik A. , Kowal M. , Sztanke K. , Sztanke M. , Borzecki A.

Bulletin of the Veterinary Institute in Puławy

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2011

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tom 55

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nr 1

EN

The aim of the study was to analyse the effect of aflatoxin B₁ (AFB1) on total antioxidant status (TAS). The studies were conducted on Wistar male rats weighing 190-200 g. The animals were given for 7 d varied doses of AFB1, from 0.5 mg/kg b.w. to 2 mg/kg b.w. TAS and concentration of uric acid were determined in blood serum. The administration of AFB1 caused a decrease in TAS value, the most significant in the rats, which received the highest dose. AFB₁ disturbed the second line of defence against free radicals, which was proved by an increase in the second line defence antioxidant, i.e. uric acid.

6

Antioxidant status and concentration of selected trace metals in placental tissues obtained from inhabitants of southern Poland

75%

Pietrzycka A. , Stepniewski M. , Kitlinski M. , Zamorska L. , Zadrozna M. , Solarska K.

Acta Biologica Cracoviensia. Series Zoologia

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2007

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tom 49

49-57

7

Protective influence of natural anthocyanins of Aronia melanocarpa on selected parameters of antioxidative status in experimental intoxication with sulphide-2-chloroethyl-3-chloropropyl

75%

Kowalczyk E. , Charyk K. , Fijalkowski P. , Niedworok J. , Blaszczyk J. , Kowalski J.

Polish Journal of Environmental Studies

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2004

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tom 13

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nr 3

EN

Sulphide-2-chloroethyl-3-chloropropyl is an alkylating agent. It posssesses mutagenic and carcinogenic properties, participates in oxidative processes and can induce lipid peroxidation.The aim of our investigation was to define antioxidative activity of natural anthocyanins after single experimental intoxication with sulphide-2-chloroethyl-3-chloropropyl in mice. Catalase activity in hemolysate, thiobarbituric acid reacting substances (TBARS) concentration in hemolysate and selected organs were determined. The study confirms increased lipid peroxidation as a result of sulphide-2-chloroethyl-3-chloropropyl intoxication, but natural anthocyanines derived from Aronia Melanocarpa also seem to play a protective role as an antioxidative agent.

8

Effects of nitric oxide synthase inhibitor on exercise-mediated pro- and anti-oxidative balance in rat blood plasma

75%

Frankiewicz-Jozko A. , Grudzinski I. P.

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2005

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tom 56

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nr 4

EN

Rats were subjected to different running trainings on a treadmill for 3 weeks, including continuous endurance and intermittent exercises at speed intensity of 10,22 and 30 m/min (°15), respectively. On the last day of the training period, the animals were dosed with Nw-nitro-L-arginine methyl ester, L-NAME (30 mg/kg b.w.), and they were further subjected to exhaustive running exercise (22 m/min; °15). Studies showed that inhibition of nitric oxide synthase (NOS) with L-NAME mitigated pro- and anti-oxidative (TB/TA) balance in the blood plasma of rats subjected to exhaustive exercise. Intermittent training before the exhaustive exercise enhanced L-NAME-induced effects on TB/TA levels in rats, but it was not observed in continuous endurance trainings

PL

Szczury poddawano różnym treningom biegowym na bieżni przez okres 3 tygodni, w tym wysiłkom ciągłym o charakterze wytrzymałościowym i interwałowym przy szybkościach 10, 22 i 30 m/ min (°15). Ostatniego dnia okresu treningowego, zwierzęta otrzymywały ester metylowy Nw-nitro- L-argininy, L-NAME (30 mg/kg m.c.), po czym były one poddawane wysiłkowi biegowemu do wyczerpania (22 m/min; °15). Badania wykazały, że inhibicja syntezy tlenku azotu (NOS) za pomocą L-NAME obniżała równowagę pro- i anty-oksydacyjną (TB/TA) w osoczu krwi szczurów poddawanych wysiłkowi do wyczerpania. Interwałowy trening, który przeprowadzano przed wysiłkiem do wyczerpania zwiększał efekty indukowane przez L-NAME na poziom TB/TA u szczurów, czego nie odnotowano po zastosowania wysiłków ciągłych o charakterze wytrzymałościowym.

9

Blood antioxidant defence in horses during physical exercises

63%

Krumrych W.

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2010

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tom 54

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nr 4

EN

The aim of the study was to evaluate the antioxidative potential of blood during standard physical exercise of horses. The study included 114 clinically healthy horses representing different groups: breeding horses (27), recreation horses (22), and sport horses (65). The group of sport horses consisted of race horses (11), trotters (15), and jumping (25) and driving horses (14). The blood was collected from external jugular vein three times: before exercise, immediately after exercise, and after 30-min rest. The following enzymatic and nonenzymatic antioxidative indices were determined: superoxide dismutase, glutathione peroxidase (GPx), catalase, albumin, total bilirubin, uric acid, and total antioxidant status (TAS). The study demonstrated a temporary post exercise mobilisation of antioxidative mechanisms, especially in cases of intensively trained competitive horses. It was demonstrated that among the antioxidants, the activity of GPx showed the high post-exercise changeability, which suggests a great importance of this enzyme in the protection of the organism from the increased generation of reactive oxygen species. The analysis of results of pre- exercise examination indicated higher rest values of main antioxidative enzymes and TAS in horses trained regularly and intensively than those in animals of a small physical activity. These results prove the positive influence of training on antioxidative potential of blood in horses.

10

Does hydrogen-rich water mitigate MP toxicity in rainbow trout (Oncorhyncus mykiss)? Monitoring with hematology, DNA damage, and apoptosis via ROS/GSH/MDA pathway

63%

Atamanalp M. , Kırıcı M. , Köktürk M. , Kirici M. , Alwazeer D. , Kocaman E. M. , Ucar E. , Parlak V. , Özcan S. , Alak G.

Oceanological and Hydrobiological Studies

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2023

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tom Vol. 52, No. 2

206--220

EN

Although the number of studies documenting the presence of Microplastics (MP) in fish is increasing, research studies focused on its detoxification are very limited. In this study, rainbow trout ( Oncorhyncus mykiss) were randomly divided into two groups after being fed with MPs (15% polypropylene [PP] +15% polyethylene [PE]) for 2 months. MP excretion without any application (PP+PE) in group I fish, and excretion of MPs with hydrogen-rich water (HRW) application (PP+PE+HRW) in group 2 were investigated under semi-static conditions for 21 days. This effectwas also compared by using positive and negative control groups (Control[no treatment, free PP, PE or/and HRW] and only HRW group). In thisdirection, the following were determined: PP+PE chronic toxicity in aquatic organisms, the toxicity mechanism and the effect of HRW as a possibletreatment method in blood tissue; with hematological indices ([RBC count [RBC], leukocyte count [WBC], hemoglobin value [Hb], hematocrit ratio [Hct], platelet count [PLT], hemoglobin count per erythrocyte [MCHC],mean hemoglobin amount per erythrocyte [MCH] and mean erythrocyte volume [MCV]) in other tissues (liver, gill and brain tissue) oxidative stress response (catalase [CAT]), glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), glutathione (GSH), reactive oxygen products (ROS), malondialdehyde ([MDA] levels), DNA damage (8-OHdG: 8-Hydroxy-2-Deoxyguanosine), and the apoptosis (caspase 3) levels were investigated. In addition, acetylcholinesterase enzyme (AChE) activity, which is important in neurotoxicity pathways in the brain, wasdetermined. The presence of plastics (PP/PE) in target tissues (muscle, liver,gill and gastrointestinal tract) was also obtained.The results showed that PP+PE caused toxicity in all three tissues. MPs showed an inhibiting effect on antioxidant enzyme activities and an inductive effect on MDA, ROS, 8-OHdG, and caspase 3 levels. HRW showed a mitigating effect on MP-mediated toxicity in O. mykiss brain, blood, gill, and liver by controlling the ROS/ GSH/MDA pathway. HRW can be suggested as a cost-effective and eco-friendly curative for the protection of fish from the oxidative damages produced by the ingestion of microplastics.

11

Effects of light wavelength on daughter cladode growth and quality in edible cactus Nopalea cochenillifera cultured in a plant factory with artificial light

63%

Horibe T. , Imai S. , Matsuoka T.

Journal of Horticultural Research

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2018

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tom 26

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nr 2

12

Responses of antioxidant status in the gills of brown trout (Salmo trutta m. trutta L.) with ulcerative dermal necrosis

63%

Tkachenko H. , Kurhalyuk N. , Palczynska K.

Baltic Coastal Zone. Journal of Ecology and Protection of the Coastline

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2011

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tom 15

EN

Antioxidant defence system (activities of superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase), and free radical modification of lipids were determined in the gills from male and female brown trout (Salmo trutta m. trutta L.) affected by ulcerative dermal necrosis (UDN). In both males and females, lipid oxidation in the gills from UDN-affected trout showed higher values as compared to the respective control. UDN induced an increase of thiobarbituric acid reactive substances (TBARS) levels both in the gills of males and females. UDN caused a decrease in gill antioxidant enzyme activities. This might be due to inactivation of the abovementioned enzymes by the end products of lipid peroxidation. The importance of the glutathionemediated antioxidant defence system in protection against UDN-induced oxidative stress was demonstrated.

PL

W pracy przedstawiono wyniki badań dotyczących występowania stresu oksydacyjnego w tkance skrzeli samców i samic troci wędrownej (Salmo trutta m. trutta L.) z wrzodziejącą martwicą skóry. Pod względem badawczym skrzela stanowią wartościową tkankę, która w największym stopniu narażona jest na oddziaływanie niekorzystnych czynników środowiska. Uzyskane wyniki badań wykazały zróżnicowanie poziomu intensywności procesów lipoperoksydacji (ocenianych przez poziom TBARS produktów) oraz aktywności enzymów antyoksydacyjnych (dysmutazy ponadtlenkowej, katalazy, reduktazy i peroksydazy glutationowej) w okresie tarła u osobników troci wędrownej zdrowych i chorych z wrzodziejącą martwicą skóry. Pobór materiału badawczego z rzeki Słupi (Północna Polska) odbył się we ścisłej współpracy z Dyrekcją Parku Krajobrazowego „Dolina Słupi” oraz Zarządem Okręgu Polskiego Związku Wędkarskiego w Słupsku w latach 2007-2009. Wyniki naszych badań sugerują istotne zwiększenie poziomu procesów peroksydacji lipidów w tkance skrzeli troci – dla samców trzykrotne, dla samic – o 3,5 raza. Wspomniane schorzenie wywołuje stres oksydacyjny w skrzelach ryb z inhibicją mechanizmów antyoksydacyjnej obrony. Obniżenie aktywności podstawowych enzymów antyoksydacyjnych z jednoczesną intensyfikacją procesów peroksydacji lipidów obniża wydajność procesów tarłowych tego gatunku ryb.

13

D-carvone, a monoterpene reverses alterations in heart rate, nitric oxide, aortic lipids and enzymatic antioxidant status in nitric oxide deficient hypertensive rats

63%

Rajeshwari T. , Raja B.

International Letters of Natural Sciences

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2015

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tom 05

EN

The present study was aimed to assess the antihyperlipidemic, antihypertensive and antioxidant effect of D-carvone, a monoterpene against Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension. Hypertension was prompted in adult male albino rats of the Wistar strain by oral administration of the L-NAME (40 mg/kg body weight) in drinking water for 4 weeks. Rats were treated with D-carvone (5, 10 and 20 mg/kg body weight) for four weeks. L-NAME treated rats exhibited significant increase in water intake, heart rate, aortic lipids level such as triglycerides (TG), total cholesterol (TC), free fatty acids (FFA) and significant decrease in the level of phospholipids (PL), plasma nitric oxide (NO). The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were decreased in erythrocytes of L-NAME induced hypertensive rats. Treatment with D-carvone restored all the above parameters to near normal level. These results suggest that D-carvone acts as an antihyperlipidemic, antihypertensive and antioxidant agent against L-NAME induced hypertensive rats.

14

Wytłoki owocowe jako dodatek do kruchych ciastek

63%

Siemianowska E. , Wesołowski A. , Barszcz A. , Radzymińska M. , Aljewicz M. , Tyburski J.

Przemysł Spożywczy

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2016

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tom T. 70, nr 10

41--45

PL

Wytłoki owocowe pozostałe po produkcji soków to bogate źródło substancji bioaktywnych o działaniu prozdrowotnym. W ramach projektu z przetwórstwa ekologicznego wypieczono kruche ciastka z dodatkiem wytłoków truskawek, malin, aronii, czarnej porzeczki i jabłek. Do wypieku użyto mąki jasnej i ciemnej z prastarych odmian pszenicy: samopszy, płaskurki, orkiszu jarego i orkiszu ozimego. Po czterech dniach od wypieku wykonano ocenę sensoryczną ciastek, oznaczono aktywność antyoksydacyj ną, parametry przechowalnicze, takie jak wilgotność i aktywność wody, oraz wybrane właściwości mechaniczne. Dodatek wytłoków owocowych w sposób zróżnicowany wpływał na twardość ciastek, ale nie powodował znacznego pogorszenia parametrów sensorycznych i przechowalniczych. Oznaczono wysoką aktywność antyoksydacyjną wszystkich ciastek wynoszącą 52,5-66,5%. Wykazano, że możliwe jest wzbogacenie kruchych ciastek wytłokami owocowymi nawet o 30% bez znacznego pogorszenia ich cech teksturalnych.

EN

Pomace, resulting after juice production, is abundant in bioactive substances with pro-health activity. So, it can be used as valuable component of shortcakes. Within the ecologic processing project, the shortcakes with addition of 10, 20 and 30% of strawberry, raspberry, black chokeberry, black currant and apple pomace were baked. White and brown flours of old wheat varieties: einkorn wheat, emmer wheat and spring and winter spelt were used. Sensory assessment of the cakes was performed, and antioxidant activity, preservation properties: moisture, water activity, four days of baking were determined. Addition of the pomace differently influenced the shortcakes hardness but it did not cause a considerable sensory and preservation parameters. High antioxidant activity at the level of 52.5-66.5% was determined. It has been proved that enrichment of the shortcakes with pomace, even at a level of 30%, is possible without considerable worsening their textural properties.

15

Total antioxidant status and 8-hydroxy-2'-deoxyguanosine levels in gingival and peripheral blood of periodontitis patients

63%

Konopka T. , Krol K. , Kopec W. , Gerber H.

Archivum Immunologiae et Therapiae Experimentalis

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2007

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tom 55

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nr 6

16

Rat colonic lipid peroxidation and antioxidant status: the effects of dietary luteolin on 1,2-dimethylhydrazine challenge

63%

Manju V. , Balasubramaniyan V. , Nalini N.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr 3

17

Antioxidant status of lambs fed on diets supplemented with selenite or Se-yeast

63%

Boldizarova K. , Gresakova L. , Faix S. , Mellen M. , Leng L.

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tom 14

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nr 2

18

Alteration in antioxidant status and lipid peroxidation of sheep previously treated with vitamin A and beta-carotene during breeding and periparturient period

63%

Kamiloglu N. N. , Beytut E. , Aksakal M.

Bulletin of the Veterinary Institute in Puławy

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2006

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tom 50

|

nr 2

19

The effect of brachytherapy on antioxidant status and lipid peroxidation in patients with cancer of the uterine cervix

63%

Mila-Kierzenkowska C. , Kedziora-Kornatowska K. , Wozniak A. , Drewa T. , Wozniak B. , Drewa S. , Krzyzanska-Malinowska E. , Makarewicz R.

Cellular and Molecular Biology Letters

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2004

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tom 09

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nr 3

EN

The aim of this study was to investigate the effect of brachytherapy on lipid peroxidation and antioxidant status in patients with uterine cervix cancer. The study was conducted on 84 uterine cervix cancer patients from the Brachytherapy Department of the Regional Centre of Oncology in Bydgoszcz. Patients with uterine cervix cancer were found to have elevated levels of lipid peroxidation and antioxidant defence system impairment relative to healthy females. The results of the study indicate that brachytherapy has no direct effect on the antioxidant system of patients with uterine cervical carcinoma. However, the normalisation of catalase and glutathione peroxidase activity and erythrocyte TBARS level observed six months after the end of therapy may be due to the arrest of the progression of the disease.

20

The effect of microcrystalline chitosan on total antioxidant status, intracellular ion concentration and [Ca2plus]ATPase activity in Ehrlich ascites tumor cells in vitro

63%

Grabowska M. , Ignacak J. , Struszczyk H.

Acta Biologica Cracoviensia. Series Zoologia

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2001

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tom 43