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1
Content available Antidepressant-like and anxiolytic-like activity of a novel indoleamine derivative ADN -2013 in rodents
100%
Wasik A. , Partyka A. , Jastrzębska-Więsek M. , Kołaczkowski M. , Wesołowska A.
Medicina Internacia Revuo
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2017
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tom 28
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nr 108
152-162
EN
A novel indolamine derivative, ADN-2013, has been proved to possess a preclinical activity profile appropriate for the treatment of behavioral and psychological symptoms of dementia. Its antidepressant and anxiolytic properties have been examined in rat and mice models. The receptor mechanisms underlying the antidepressant properties of ADN-2013 have also been elucidated. ADN-2013 significantly shortened the immobility time measured in the forced swim test in mice and rats, producing an effect that was abolished by the dopamine D1-receptor antagonist SCH 23390 in rats. Moreover, ADN-2013 evoked anxiolytic-like activity in both “conditional” and “unconditional” anxiety-like paradigms in mice and rats. From these results, it is likely that direct antagonism toward serotonin 5-HT6 receptors and an indirect effect of dopamine, acting mostly via D1-like receptors, may be involved in the antidepressant action of ADN-2013. However, the partial agonist activity of ADN-2013 toward D2 receptors, observed in in vitro studies, might also contribute to this effect.
2
Content available Dziurawiec w terapii łagodnych i umiarkowanych zaburzeń depresyjnych
84%
Zielińska A.
Lek w Polsce
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2022
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tom 376
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nr 09
7-12
EN
According to the World Health Organization (WHO), depression is a mental disorder that affects over 350 million people worldwide. Typically used antidepressants, e.g. from the group of selective serotonin reuptake inhibitors (SSRIs), despite their effectiveness, have many undesirable side effects. For this reason, alternative methods of alleviating the symptoms of depression are being sought. St. John's wort (Hypericum perforatum L.) has been used as herbal remedy for this disease for many years, especially in Germany and other European countries, although its effectiveness is still controversial. However, meta-analyzes of clinical trials published in recent years have confirmed that St. John's wort may be an effective therapy in mild and moderate depression. H. perforatum extract shows comparable effectiveness to standard antidepressant drugs (SSRIs), while the percentage of side effects and dropouts is significantly lower than with SSRIs. St. John's wort extract may be the preferred choice in the treatment of mild to moderate depressive states.
PL
Według Światowej Organizacji Zdrowia (WHO) depresja to zaburzenie psychiczne, na które cierpi ponad 350 mln osób na całym świecie. Klasycznie stosowane leki antydepresyjne, m.in. z grupy selektywnych inhibitorów wychwytu zwrotnego serotoniny (SSRIs), pomimo swojej skuteczności, wykazują wiele niepożądanych działań ubocznych. Dlatego cały czas poszukuje się alternatywnych metod łagodzenia objawów depresji. Dziurawiec zwyczajny (Hypericum perforatum L.) stosowany jest jako środek ziołowy na tę chorobę od wielu lat, zwłaszcza w Niemczech i w innych krajach europejskich, choć jego skuteczność nadal budzi wiele kontrowersji. Jednak metaanalizy badań klinicznych opublikowane w ostatnich latach potwierdziły, że ziele dziurawca może stanowić skuteczną terapię w stanach łagodnej i umiarkowanej depresji. Ekstrakt z H. perforatum wykazuje porównywalną efektywność do standardowych leków antydepresyjnych (SSRIs), podczas gdy odsetek efektów niepożądanych i rezygnacji z terapii jest znacznie niższy niż w przypadku SSRIs. Ekstrakt z dziurawca zwyczajnego może być preferowanym wyborem w terapii łagodnych i umiarkowanych stanów depresyjnych.
3
Content available Relative profiling of L-tryptophan derivatives from selected edible mushrooms as psychoactive nutraceuticals to inhibit P-glycoprotein: a paradigm to contest blood-brain barrier
84%
Margret A. A. , Mareeswari R. , Kumar K. A. , Jerley A. A.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2021
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tom 102
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nr 1
4
The infuence of antidepressants on the immune system
84%
Szalach L. P. , Lisowska K. A. , Cubala W. J.
Archivum Immunologiae et Therapiae Experimentalis
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2019
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tom 67
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nr 3
5
Content available remote Involvement of the monoaminergic system in the antidepressant-like activity of chromium chloride in the forced swim test
84%
Piotrowska A. , Siwek A. , Wolak M. , Pochwat B. , Szewczyk B. , Opoka W. , Poleszak E. , Nowak G.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 4
6
Content available Właściwości fizykochemiczne i użytkowe biopaliw B50 skomponowanych w wersji letniej i zimowej przeznaczonych do zasilania pojazdów rolniczych
84%
Wolszczak J. , Jakubiec J.
Inżynieria Rolnicza
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2010
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tom R. 14, nr 5
299-309
PL
Biopaliwa B50L i B50Z otrzymano w laboratorium przez zmieszanie równych objętości handlowego Bioestru B100 (estry metylowe oleju rzepakowego) z handlowymi olejami napędowymi. Zbadano właściwości fizykochemiczne i użytkowe paliw wyjściowych oraz mieszanek B50 skomponowanych w wersji letniej (B50L) i w wersji zimowej (B50Z). Stwierdzono, że z wyjątkiem dwóch parametrów: liczby kwasowej dla biopaliwa B50L i indeksu cetanowego dla mieszanki B50Z, pozostałe parametry jakościowe spełniają wymagania określone dla biopaliwa B20. Oceniono skuteczność działania wybranych dodatków depresujących oraz stabilność właściwości niskotemperaturowych depresowanych biopaliw B100 i B50. Proponowane biopaliwa B50 mogą znaleźć zastosowanie w eksploatacji maszyn rolniczych w okresie letnim i zimowym.
EN
B50L and B50Z biofuels were received in the laboratory by mixing equal volumes of commercial Bioester B100 (methyl esters of rape-seed oil) with commercial diesel oils. Physicochemical and utility properties of output fuels and B50 mixtures composed in summer version (B50L) and winter version (B50Z) and were tested. It was found that, except for two parameters: the acid number for B50L biofuel and the cetane index for B50Z mixture, other quality parameters comply with requirements stated for B20 biofuel. The efficiency of operation of selected antidepressant additives and the stability of low-temperature properties of B100 and B50 biofuels treated with antidepressant additives were evaluated. Proposed B50 biofuels can be used for the operation of agricultural machines in summer and winter seasons.
7
Serotonin and neurogenesis in the hippocampal dentate gyrus of adult mammals
84%
Djavadian R. L.
Acta Neurobiologiae Experimentalis
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2004
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tom 64
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nr 2
8
Content available remote Human opiorphin is a naturally occurring antidepressant acting selectively on enkephalin-dependent delta-opioid pathways
67%
Javelot H. , Messaoudi M. , Garnier S. , Rougeot C.
Journal of Physiology and Pharmacology
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2010
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tom 61
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nr 3
355-362
EN
Human opiorphin protects enkephalins from degradation by human neutral endopeptidase and aminopeptidase-N and inhibits pain perception in various behavioral rodent models of pain via endogenous enkephalin-related activation of opioidergic pathways. In addition to pain control, endogenous opioid pathways are also implicated in the modulation of emotion-related behaviors. Thus, we explored the dose-dependent motivational responses induced by opiorphin using the forced swim test, the standard rat model of depression. In addition, to further understand the endogenous events triggered by opiorphin, we investigated the specific involvement of µ- or -opioid receptor-dependent pathways. In parallel, the locomotor activity test was used to detect possible sedation or hyperactivity. Here, we report for the first time that at 1-2 mg/kg i.v. doses, opiorphin elicited antidepressant-like effects by activating endogenous -opioidergic pathways, since that activation was reversed by the selective -opioid antagonist naldrindole (10 mg/kg i.p.). The antidepressive behavioral responses exerted by opiorphin are specific at systemically active doses. Treated-rats did not develop either hypo- or hyper-active responses in a locomotor test or amnesic behavioral response in the passive avoidance rat model. In addition, opiorphin did not induce either anxiolytic-, or anxiogenic-like responses in the conditioned defensive burying test. Taking the data together, we conclude that opiorphin is able to elicit antidepressant-like effects, mediated via -opioid receptor-dependent pathways, by modulating the concentrations of endogenous enkephalin released in response to specific physical and/or psychological stimuli. Thus, opiorphin or optimized derivatives is a promising single candidate to treat disorders that include both pain and mood disorders, particularly depression.
9
Content available remote Effect of venlafaxine and nicotine on the level of neurotransmitters and their metabolites in rat brains
67%
Czubak A. , Nowakowska E. , Golembiowska K. , Kus K. , Burda K. , Metelska J.
Journal of Physiology and Pharmacology
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2010
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tom 61
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nr 3
339-346
EN
Nicotine (NIC) and venlafaxine (VEN) have been proved to exert antidepressant activity in both human and animals. The effect of antidepressant doses of NIC and VEN (our previous results) on noradrenergic (NA), dopaminergic (DA), serotoninergic (5-HT) neurotransmitters and their metabolites: DOPAC, HVA and 5-HIAA in rats’ hippocampus in freely moving rats were determined by microdialysis technique and HPLC method. Both drugs release 5-HT and NA, but VEN to a greater degree. DA level was affected only by VEN, however NIC extended the response of the DA system on VEN’s effect. Combined administration of drugs caused the greatest changes in the 5-HT system. Both drugs contributed to reduction in neurotransmitter biotransformation.
10
Content available remote Protective effects of vortioxetine in predator scent stress model of post-traumatic stress disorder in rats: role on neuroplasticity and apoptosis
67%
Ozbeyli D. , Aykac A. , Alaca N. , Hazar-Yavuz A. N. , Ozkan N. , Sener G.
Journal of Physiology and Pharmacology
|
2019
|
tom 70
|
nr 4
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