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Molecular interactions in lomefloxacin-liposome systems

100%

Budai M. , Pallaghy R. , Szabo Z. , Zimmer A. , Grof P.

Cellular and Molecular Biology Letters

2005

tom 10

nr Suppl.

The effect of nitrofurazone and furazolidone on induction of cytochrome P-450 dependent monooxygenase system

75%

Czeczot H. , Kobierska-Szeliga M. , Bilbin M.

Acta Biochimica Polonica

1992

tom 39

nr 1

Improved analytical procedure for the determination of sulfonamides in honey

63%

Posyniak A. , Jazdzewski K. , Pietruszka K. , Mitrowska K. , Gajda A.

Bulletin of the Veterinary Institute in Puławy

2008

tom 52

nr 1

An improved liquid chromatography-fluorescence detection method for the determination of seven sulfonamides in bee honey was proposed. The method is selective and robust enough for the required purposes. The whole procedure was validated in accordance with the Commission Decision 657/2002/EC. Detection capabilities were from 26.15 to 49.50 µg/kg, and recoveries ranged from 32.8% to 116.1%, depending on the analyte.

Modified substrates of DNA polymerases and design of antivirals

63%

Krayevsky A. A. , Alexandrova L. , Dyatkina N. B. , Kukhanova M. K. , Shirokova E. A.

tom 43

nr 1

The results obtained in our laboratory on investigating of substrate properties of a large number of compounds towards different DNA polymerases have been summarized. On the basis of systematic analysis a directed synthesis of nucleotides with antiviral properties was performed.

Jak wykonać regionalną perfuzję kończyny u konia

51%

Poulin Braim A.

Weterynaria po Dyplomie

2017

tom 18

nr 1

The decline of antibiotic era - new approaches for antibacterial drug discovery

51%

Jagusztyn-Krynicka E. K. , Wyszynska A.

Polish Journal of Microbiology

2008

tom 57

nr 2

Infectious diseases still remain the main cause of human premature deaths; especially in developing countries. The emergence and spread of pathogenic bacteria resistant to many antibiotics (multidrug-resistant strains) have created the need for the development of novel therapeutic agents. Only two new classes of antibiotics of novel mechanisms of action (linezolid and daptomycin) have been introduced into the market during the last three decades. The recent progress in molecular biology and bacterial genome analysis has had an enormous impact on antibacterial drug research. This review presents new achievements in searching a new bacterial essential genes, a potential targets for antibacterial drugs. Application of metagenomics strategy is also shown. Some recent technologies aimed at development of anti-pathogenic drugs such as inhibitors of quorum sensing process or histidine kinases are also discussed. Extensive research efforts have provided many details concerning structure of bacterial proteins playing an important role in pathogenesis such as adherence proteins or toxins, what allowed searching for antitoxin drugs or drugs interfering with bacterial adhesion. As an example, the review focuses on anthrax therapies under development. Additionally, the article presents the progress in phage therapy; using bacteriophages or their products such as lysins in antibacterial therapy.

Atopowe zapalenie skóry u psów - najnowsze wiadomości na temat rozpoznawania i leczenia

32%

Banovic F.

tom 20

nr 3