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Expression of Bcl-2 and Bax proteins in thyroid glands of rats in experimental thyroiditis

100%

Markovic L. , Todorovic J. , Stankovic G. , Radojevic S. , Gvozdenovic E. , Aritonovic J. , Stupar N. , Vojinovic Maglic G.

Folia Biologica

2010

tom 58

nr 3-4

163-169

Mutations in the KRAS gene in ovarian tumors

100%

Dobrzycka B. , Terlikowski S. J. , Kowalczuk O. , Niklinska W. , Chyczewski L. , Kulikowski M.

Folia Histochemica et Cytobiologica

2009

tom 47

nr 2

221-224

Effect of juglone on C-32 and COLO 829 melanoma cells in in vitro cultures

100%

Zielinska A. , Plonka-Czerw J. , Kusmierz D.

nr 1

Antiapoptotic proteins as targets for bioactive compounds

100%

Pajak B.

tom 10

nr 2

One of the most promising strategies in colon cancer therapy is the sensitization of cancer cells to natural proapoptotic cytokines, such as death ligands and interferons, which are able to eliminate abnormal cells. The investigation of mechanisms determining the immune escape of cancer cells revealed the presence of antiapoptotic proteins, such as cFLIP, which inhibit cell death signal transduction. Numerous studies showed that the use of different metabolic inhibitors, such as cycloheximide (CHX), reduces the cFLIP protein level, thus restoring the susceptibility to TNF-a-induced apoptosis. However, high non-specific toxicity of CHX excludes the clinical use of this substance. The current efforts are focused on identification of bioactive compounds which could safely support immunotherapy. The review presents in vitro and in vivo evidence that butyrate (Bt), fatty acid produced in colon during fermentation process and parthenolide (PN), sesquiterpene lactone isolated from Tanacetum parthenium specifically affect different cancer cells. Among described various molecular mechanisms of Bt and PN action, one reduces the level of antiapoptotic proteins. This paper clearly demonstrates that bioactive compounds, especially combined with immune cytokines could be seriously considered as an alternative for routine colon anti-cancer therapy.

Survivin is a key factor in the differential susceptibility of gastric endothelial and epithelial cells to alcohol-induced injury

80%

Jones M. K. , Padilla O. R. , Zhu E.

Journal of Physiology and Pharmacology

2010

tom 61

nr 3

253-264

We previously demonstrated that the anti-apoptosis protein, survivin, plays a protective role against alcohol-induced gastric injury. Since the endothelium is a primary target of alcohol-induced gastric damage, we investigated whether survivin expression is a key factor in the greater susceptibility of gastric endothelial vs. epithelial cells to alcohol-induced injury. Here, we demonstrate that rat gastric epithelial cells (RGM1 cells, an epithelial cell line derived from normal rat gastric mucosa) expressed 7.5-fold greater survivin protein levels vs. rat gastric endothelial cells. Survivin expression correlated with resistance of gastric epithelial vs. endothelial cells to both alcohol-induced cell damage and alcohol-induced apoptosis. Suppression of survivin protein expression levels using siRNA rendered the gastric epithelial cells as susceptible to both alcohol-induced cell damage and apoptosis as the gastric endothelial cells. Conversely, forced overexpression of survivin by transient transfection rendered gastric endothelial cells as resistant to both alcohol-induced cell damage and apoptosis as mock-transfected gastric epithelial cells. Moreover, overexpression of a threonine-34 to glutamate phosphorylation mimic mutant survivin construct rendered gastric endothelial cells significantly more resistant to alcohol-induced damage and apoptosis vs. mock-transfected gastric epithelial cells. These findings indicate that disparate survivin expression levels can explain the discrepancy between gastric epithelial and endothelial cell susceptibility to alcohol-induced injury; and, that a negative charge at amino acid residue 34 on survivin, such as that which naturally occurs by phosphorylation of threonine-34, enhances its property in conferring gastric mucosal protection.

Innate immunity signaling pathways: links between immunonutrition and responses to sepsis

80%

Slotwinski R. , Slotwinska S. , Kedziora S. , Balan B.-J.

2011

tom 59

nr 2