Wyniki wyszukiwania - Biblioteka Nauki

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Wood decay mushrooms of the genus ganoderma as a source of biologically active triterpenes

100%

Sułkowska-Ziaja K. , Piechaczek M. , Pacławska A. , Muszyńska B.

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nr 109

237-245

EN

Species of the genus Ganoderma are an example of some of the most thoroughly studied representatives of Basidiomycota both in terms of chemical composition and biological activity. Among the compounds found in this kind, the therapeutic effect is primarily associated with the polysaccharides that are heteroglycans or β-D-glucans and terpenoids represented mainly by triterpenes. Triterpene compounds have a structure composed of 30 carbon atoms, usually forming a system of five six-membered rings. Characteristic of these structures are functional groups (hydroxyl, carboxyl or ketone) and double bonds. Mycochemical studies have led to the isolation of numerous triterpenes of the lanostane type (ganoderic acids, aldehydes, alcohols, esters), lucidenic acids and others from various species of the Ganoderma genus. The broad spectrum of biological activity determined by triterpene compounds includes anti- tumor, anti-inflammatory, antioxidant, hepatoprotective, antidiabetic, and antiviral effects. This work describes biologically active triterpenes in selected species of the genus Ganoderma: Ganoderma lucidum, Ganoderma applanatum, Ganoderma adspersum, Ganoderma pfeifferi, Ganoderma colossum and others. These species are sources of natural compounds valued for thousands of years in the traditional medicine of the Far East, while ongoing research has confirmed their medicinal properties nowadays.

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Investigation of the Antioxidant and Anti-Inflammatory Capacities of Different Extracts from Cistus ladanifer L. Leaves in the Ait Ammart Region (Northern Morocco)

88%

Benamari O. , Labhar A. , Ahidar N. , Salhi A. , Ahari M. h. , Elyoussfi A. , Benyoub B. , Amhamdi H.

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2024

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tom Vol. 25, iss. 3

178--184

EN

Plants are a significant source for identifying new compounds (particularly secondary metabolites) with medicinal value for drug development, pharmaceuticals, and food additives. Many of these healing plants are frequently used in conventional medicine to treat and prevent various diseases. The purpose of the current research is to assess the total phenolic content (TPC) and total flavonoid content (TFC) for phytochemical analysis, DPPH and FRAP (Ferric Reducing Antioxidant Power) assays for antioxidant activity (AOA), and the activity of reducing inflammation exhibited by various extracts, which were determined by measurement of absorbance with a UV spectrophotometer. The outcome demonstrated that the Cistus ladanifer L leaf aqueous extract (EAqCL) has the highest yield (15.581%) and the highest phenolic content (98.28 ± 0.32 mg GAE/gext) compared to the other extracts. Whereas, ethanol extract (EECL) exhibited the highest flavonoid content (11.39 ± 1.45 mg QE/gext), DPPH-radical scavenging activity (RSA = 94.534 ± 1.24%) at 800 μg/ml and FRAP (1.017 ± 0.12) at 400 μg/mL. The extract also showed better anti-inflammatory activity (95.61 ± 0.92%) at 1000 μg/ml. According to the results obtained, this sticky shrub growing in the Ait Ammart region has great potential for exploiting natural sources of bioactive substances and producing pharmacologically active metabolites.

3

Synthesis, Characterization and Anti-inflammatory Activity of Some Organotin(IV) Complexes

88%

Rehman W. , Rehman S. , Muhammad B. , Shah S. T. , Tauseef I. , Guo C. Y.

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2009

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tom Vol. 83, nr 12

2043-2049

EN

The synthesis and characterization of new coordination compounds of some organotin(IV) chlo rides with fexofenadine are reported; the ligand molecules appear to be bound to the tin atom through carbonyl oxygen atom. The structure of the synthesized compounds has been characterized by elemental analyses, and bonding in these complexes is discussed in terms of their IR, 1H NMR and through Mössbauer studies. The spectroscopic results obtained are in full agreement with the proposed 1:1 stoichiometry. The synthesized complexes have been screened for anti-inflammatory effect. The results obtained showed that triphenyltin(IV) derivatives of fexofenadine exhibited promising anti-inflammatory effect as compared to the other tin(IV) derivatives of the same ligand.

4

New thiopyridine complexes: design, electrochemical preparation and biological assessment

88%

El-Sabbagh O. I. , Yamany B. Y. , Eldeab H. A.

Polish Journal of Chemical Technology

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2019

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tom Vol. 21, nr 4

20--25

EN

Novel complexes of Ru (III), Cu (II) and Au (III) (2–4) were prepared using 6-phenyl-2-thioxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (HL, 1) adopting either electrochemical or traditional chemical methods. The electrochemical method is preferred in the synthesis of the complexes than the chemical one because it affords pure products with higher yields in shorter reaction time. The novel thiopyridine complexes were characterized by elemental analyses, IR, 1H, 19F-NMR, TGA and DTA measurements. The antimicrobial activity evaluation revealed that the complex bearing copper metal 3 has nearly the same activity as the reference drug ciprofloxacin. Anti-inflammatory activity evaluation showed that complex 4 containing gold displayed anti-inflammatory activity higher than the reference drug celecoxib upon using carrageenan rat hind paw edema method.

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Antibacterial, antifungal, anti-oxidant, anti-inflammatory and anti-hypertensive activities of N-chloropyrazinamide

75%

Vaijayanthi S. P. , Mathiyalagan N.

International Letters of Chemistry, Physics and Astronomy

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2014

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tom Vol. 7

1--8

EN

N-chloropyrazinamide was prepared by the chlorination of pyrazinamide using trichloroisocyanuric acid. The experimental results ascertained that the tested N-chloropyrazinamide showed good antimicrobial activities when compared to standard drug. It was found that N-chloropyrazinamide at different concentrations exhibited significant dose dependent anti-oxidant, anti-inflammatory and anti-hypertensive activity.

6

Scavenging activity, anti-inflammatory and diabetes related enzyme inhibition properties of leaves extract from some varieties of Phoenyx dactylifera l.

75%

Eddine L. S. , Segn L. , Noureddine G. , Mohammed Redha O. , Mokni S.

International Letters of Chemistry, Physics and Astronomy

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2013

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tom Vol. 9, iss. 2

125-135

EN

In this study we investigate the antioxidant, anti-inflammatory, and antidiabetic activities of ethanolic leaves extracts of three selected varieties of Phoenyx dactylifera L. namely: “Ghars”, “Deglet Nour” and “Hamraya”. The assessment of the antioxidant potential of crude leaves extracts, using superoxide anions inhibition, DPPH and total antioxidant activity essays, was carried out. Furthermore, the anti-inflammatory properties of the extracts were determined by measuring the inhibition of nitric oxide (NO) production. Moreover, the antidiabetic effect was evaluated by inhibition of α-amylase enzymes. The total phenolic content measured by Folin-ciocalteu method was as well conducted. The raw leaves extracts of the selected varieties was found to contain a high content of total phenolic content (342.45 mg GAE/gDW for GE) and therefore exhibited a higher antioxidant activity and inhibitory effect of radicals scavenging activity against DPPH and superoxide anion (IC50 = 7.44 μg/mL and 39.11 μg/mL respectively). The three varieties exhibited significant inhibition nitric oxide using in-vitro assay (IC50 = 240.28 μg/mL for GE). The extracts also displayed high inhibition actions against α-amylase enzymes. The results suggest that the leaves of the three selected varieties of Phoenyx dactylifera can be considered as a good source of natural antioxidant and anti-inflammation drugs as well as potent antidiabetic medicine.

7

Phytochemical, Anti-Inflammatory and Antioxidant Activities of Pistacia lentiscus L. Leaves from Ajdir, Al Hoceima Province, Morocco

75%

Labhar A. , Benamari O. , El-Mernissi Y. , Salhi A. , Ahari M. , El Barkany S. , Amhamdi H.

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tom Vol. 24, iss. 7

172--177

EN

Pistacia lentiscus L. (PL) is a shrub belonging to the Anacardiaceae family, used in traditional medicine to treat various disorders in the Commune of Ajdir from Al Hociema province. The conducted study focused on determination of the polyphenols and flavonoids contents by spectrophotometric and in vitro evaluation of the antioxidant and anti-inflammatory capacity. Determining total polyphenols shows the aqueous extract with a higher concentration of 125.04±0.01 mg EAG/g ES, followed by the ethanolic extract of 108.16±0.02 mg EAG/g ES. Determination of flavonoids revealed that the hexanoic extract contains a maximum of flavonoids with a level of 90.60±0.01 mg EQ/g ES. The antioxidant activity of different extracts was determined through two methods: DPPH and FRAP. Aqueous and ethanolic extracts showed a high antioxidant capacity. Further, regarding anti-inflammatory activity, the ethanolic extract has good activity inhibition (92.65±0.67) followed by aqueous extract (94±0.29) at 1000 μg/mL concentration. This study found that the ethanolic extracts from PL leaves are a powerful natural antioxidant and effective anti-inflammatory agent. The results indicate the extract’s effectiveness and highlight the importance of medicinal plants from the Commune of Ajdir.