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tom 10
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nr 1
EN
Peliosis hepatis (PH) is a rare condition characterized by dilatation of hepatic sinusoids and the presence of blood-filled spaces within the liver. The disease occurs mainly in subjects exposed to toxic substances or estrogens, and is often asymptomatic. A 9 year-old pekingese female dog was sent to Division of Pathology for autopsy because of sudden death of unclear cause. Autopsy revealed severe hydroperitoneum (1500 ml of transsudate), dilatation of heart ventricles, passive hyperemia of lungs, spleen and kidneys. The liver was enlarged, with slightly wrinkled surface, with many red spots, of different size and shape. Microscopic examination of the liver revealed the presence of areas with severe dilatation of hepatic sinusoids, and multiple cystic spaces filled with blood. Some of these spaces were lined with endothelium and other were not. Spaces were different in shape and size and were localized in the areas between dilated sinusoids. Based on the macroscopic and microscopic examination, the liver lesions were identified as severe hepatic sinusoidal dilatation with formation of peliosis hepatis-tike structures.
EN
The aim of this study was to investigate paraoxonase (PON1) activity and total sialic acid to be measured for the first time in sheep infected naturally with foot and mouth disease, and their relationships with oxidative stress. A total of 30 Awassi sheep (aged between 2-4), which were healthy and infected with the foot and mouth disease virus (FMDV) were used in the study. Concentrations of paraoxonase activity (PON1), which is an important antioxidant against oxidative stress, high density lipoprotein (HDL) and total sialic acid (TSA), which has a critical role for immune system and is one of the significant indicators of cellular degeneration, were measured in serum samples drawn from animals. The total oxidant capacity (TOC) and total antioxidant capacity (TAC) were evaluated to determine the oxidative balance. It was observed that serum PON1 (P < 0.001) and HDL (P < 0.01) concentrations were significantly lower compared to the control group. TSA concentration was higher in the infected group (P < 0.001) compared to the healthy group. TOC was higher (P < 0.001) and TAC was lower (P < 0.01) in the infected group compared to the control group. Consequently, harmful effects of the infection of foot and mouth disease were shown as cause of oxidative cell damage and the high rate of sialic acid was produced depending on the degeneration during the infection.
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nr 4
EN
This article reviews the actual world FMD situation. In 2000, fifty nine countries officially reported outbreaks of FMD. The disease occurred in Europe (Greece), Asia (Russia, Mongolia, Bangladesh, Cambodia, China, Japan, Laos, Nepal, Pakistan, Philippines, Republic of Korea, Taiwan, Thailand, Vietnam, Iran, Iraq, Turkey, in Caucasian region - Georgia, Azerbaijan and Armenia as well as in Kazakhstan, Kyrgyzstan, Turkmenistan and Tajikistan), Africa (Egypt, Kenya, Mauritania, South Africa, Tanzania, Uganda, Malawi, Namibia, Zambia and Zimbabwe) and in South America (Brazil, Colombia, Uruguay, Bolivia, Peru, Ecuador and Venezuela). In 2001, FMD was still spreading throughout the endemic regions and appeared in some of the west European countries - Great Britain, the Netherlands, France and Ireland. In South America, FMD occurred in Argentina, Uruguay, Brazil and Colombia. In Asia the FMD spread in Turkey, Iran, Afghanistan, Georgia, Azerbaijan, Mongolia, Kuwait, Bahrain, Yemen, Qatar, United Arab Emirates, Oman, Iran, Bhutan, Nepal, Malaysia, Philippines, Thailand and Taiwan. The FMD situation in Africa was unclear, but probably most countries in West, East and South Africa were affected. The most recent data of the OIE from May 2002 confirmed FMD outbreaks in population of pigs in Republic of Korea.
EN
The work reports a rare case of canine two primary malignant tumours concurrent with one benign tumour occurring within a single organism. Soft palate malignant melanoma with metastases to the regional lymph nodes and internal organs was classified as the index tumour, while thyroid carcinoma was defined as incidentaloma. The third tumour recognised was a large lipoma located in the abdominal cavity. The presented case proves that in the animal organism affected with a malignant tumour, other tumours may develop.
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2008
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tom 11
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nr 2
175-186
EN
Interferon-a (IFN-a) is well known as a clinically effective antiviral and antineoplastic therapeutic agent. It has also been shown to have immunoregulatory properties. IFN-a stimulates a cell-mediated innate immune response and then participates in the transition of the initial host innate response to an effective adaptive immune response. IFN-a is produced in small quantities in nasal secretions during viral infections, prompting many authors to suggest that low-dose oromucosal administration of IFN-a effectively mimics nature. Moreover, the injectable high-dose interferon therapy currently approved for various human disorders causes numerous side effects. By contrast, oromucosal administration of IFN-a is not associated with toxic effects. Another distinct advantage is ease of administration: the IFN can be dissolved in drinking water or administered by nebulization to the oral or nasal cavity. This review describes the current state of knowledge concerning orally administered IFN-a, of both human and animal origin, as a prophylactic or therapeutic agent in veterinary medicine. We present the effects of IFN-a in such animals as cattle, pigs, horses, cats, dogs and chickens, and attempt to explain its mechanism of action following oromucosal administration. It is hoped that this review of the medical literature on the use of IFN-a in animals will give practitioners a better understanding of the challenges and benefits of using this interesting cytokine in clinical practice.
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tom 14
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nr 2
EN
Twenty-seven pruritic dogs were used in this study. When a hypoallergenic diet was fed to these 27 dogs for six weeks, none of the dogs showed improvement of the pruritus. These dogs had a history and clinical signs of atopic dermatitis (AD) as defined by Prelaud’s diagnostic criteria. Subsequently, the 27 dogs were isolated for observation for two weeks in the hospital. In the isolation room in the veterinary clinic, cages and tableware were all stainless steel, and carpet was not used. A hypoallergenic diet was continuously fed to the 27 dogs for two weeks, during which time they were kept in the isolation room. PVAS (Pruritus Visual Analog Scale) was performed prior to starting the isolation, at the start of the study and 2 weeks after starting the isolation. In 17dogs (63%) the pruritus improved in the isolation room. A statistically significant reduction (p<0.01) of PLS (Pruritus liners score) was recorded 2 weeks after isolation. It was hypothesized that the 17 dogs whose pruritus improved in the isolation room had AD caused by an environmental antigen that was not present in the isolation room. Pruritus of the remaining 10 dogs (37%) did not improve. For 6/10 dogs, the intradermal allergy testing was positive for an environmental antigen. For4/10 dogs, the intradermal allergy testing was negative for all environmental antigens. Dogs for which sensitivity to an environmental antigen was not identified were thought to have atopic-like dermatitis.
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nr 1
41-46
EN
The subject of this study was to determine urine specific gravity (USg) and urinary creatinine (UCrn) in dogs with different diseases but with normal renal function. Sick dogs with different diseases were divided into nine groups. Dogs suffering from polyuria/polydipsia, vomits, diarrhoea and females in oestrus or pregnant were excluded from the studies. The healthy dogs served as a control group. Over a three-year period, a total of 267 dogs were examined clinically as well as using imaging and laboratory diagnostics methods. In sick dogs, USg and UCrn were found to be essentially decreased (except animals with neurological and uterine diseases, and neurological diseases, respectively), as compared with normal dogs. In clinically healthy animals of the control group, UCrn and USg did not significantly differ between the females and males. As for the control group, no correlation between UCrn/USg and the body weight/age was found, either.
EN
This study aimed to determine the relationship between hepcidine levels and some hematological and biochemical parameters after anemia in natural theileriosis cows. This research was conducted with a total of 25 cattle, including 10 healthy controls and 15 cattle with natural theileriosis. 1098 bp positivity was determined according to the PCR result. Leukocyte (WBC), erythrocyte (RBC), hematocrit (HCT) and hemoglobin (HGB) levels were decreased. However, red blood cell distribution width (RDW), Platelet (PLT) and hepcidin levels were increase determined in natural theileriosis cows according to the control group. In addition, a positive correlation was detected between hepsin and iron parameters although there is no statistical significance between them and a negative correlation was determined between hepcidine and HCT, HGB and RDW parameters. As a result, it was determined that erythrocyte parameters decrease and increase in iron parameters and heptidine levels in cattle with theileriosis. It can be concluded that the diagnostic importance.
PL
Pięciomiesięczny, europejski krótkowłosy kotek, trafił do kliniki okulistycznej z powodu bólu oka oraz nadmiernego łzawienia. W trakcie badania okulistycznego stwierdzono niedorozwój powieki górnej oka prawego. Ageneza występowała na odcinku 1/3 długości powieki od strony kąta bocznego. Brak fragmentu powieki powodował ciągłe drażnienie rogówki. Jedynym sposobem poprawienia komfortu życia kotka było przeprowadzenie zabiegu rekonstrukcji powieki. Zabieg wykonano metodą Roberts – Bistnera.
20
Content available What is it "dry eye" and how to treat it?
75%
PL
Suche zapalenie spojówek i rogówki u zwierząt (KCS) powstaje na skutek zubożonej produkcji łez, co skutkuje ich niedoborem. Choroba objawia się wysuszeniem powierzchni oka. Oko jest zaczerwienione, zwierzę odczuwa świąd. Pojawiają się na powierzchni rogówki keratopatie. Schorzenie występuje u psów, kotów a nawet koni. W miarę trwania choroby, wokół oczu na powierzchni powiek, odkłada się ropna wydzielina. Istnieje wiele przyczyn powodujących taki stan. Głównie są to zaburzenia natury immunologicznej, wady wrodzone, urazy, reakcje polekowe, infekcje wirusowe oraz zaburzenia hormonalne. Rozpoznanie choroby odbywa się za pomocą testu łzowego Schirmera (STT). Leczenie polega na podawaniu preparatów nawilżających oko oraz leków stymulujących produkcję łez (cyclosporyna A, tacrolimus). W przypadku, gdy leczenie takie nie przynosi oczekiwanych rezultatów, można zastosować zabieg transpozycji przewodu ślinianki.
EN
Keratoconjunctivitis sicca – KCS- “dry eye” is due to an aqueous tear deficiency. This results in persistent, mucopurulent conjunctivitis and corneal ulceration and scaring. KCS occurs in dogs, cats and horses. With time, some of the mucous can build up around the eye, becoming dry and crusty. As the conditions progresses, the cornea becomes invaded with blood vessels, scarred and pigmented. There are a number of possible causes i.e. autoimmune, congenital, trauma, drug reactions, viral infections and hormone imbalance. Dry eye is diagnosed with a Schirmer tear test. Therapy consists of artificial tear solutions, ointment and antibiotic combinations. Lacrimogenics such as topical cyclosporine A or tacrolimus may increase tear productions. In chronic KCS refractory to medical therapy, parotid duct transpostion is indicated.
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