Wyniki wyszukiwania - Biblioteka Nauki

1

Combined delivery of an antiangiogenic protein (angiostatin) and an immunomodulatory gene (interleukin-12) in the treatment of murine cancer.

100%

Wilczyńska U. , Kucharska A. , Szary J. , Szala S.

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tom 48

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nr 4

1077-1084

EN

We investigated the feasibility of a novel therapeutic approach to treat neoplastic diseases in mice. This novel strategy consists in delivering a protein (angiostatin) with strong antiangiogenic properties, followed by administration of the interleukin 12 gene that is strongly immunomodulatory and has also some antiangiogenic effects. When angiostatin-mediated antiangiogenic therapy was used in combination with intratumor delivery of the IL-12 gene (a strategy much safer than IL-12 protein administration), this produced a synergistic therapeutic effect.

2

Anti-tumor chemotherapy utilizing peptide-based approaches - apoptotic pathways, kinases, and proteasome as targets

75%

Mendoza F. J. , Espino P. S. , Cann K. L. , Bristow N. , McCrea K. , Los M.

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2005

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tom 53

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nr 1

3

Combined delivery of an antiangiogenic protein [angiostatin] and an immunomodulatory gene [interleukin-12] in the treatment of murine cancer

63%

Wilczynska U. , Kucharska A. , Szary J. , Szala S.

Acta Biochimica Polonica

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2001

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tom 48

|

nr 4

EN

We investigated the feasibility of a novel therapeutic approach to treat neoplastic diseases in mice. This novel strategy consists in delivering a protein (angiostatin) with strong antiangiogenic properties, followed by administration of the interleukin 12 gene that is strongly immunomodulatory and has also some antiangiogenic effects. When angiostatin-mediated antiangiogenic therapy was used in combination with intratumor delivery of the IL-12 gene (a strategy much safer than IL-12 protein administration), this produced a synergistic therapeutic effect.