Wyniki wyszukiwania - Biblioteka Nauki

1

Insulin resistance and adipokine levels correlate with early atherosclerosis – a study in prediabetic patients

100%

Mihai B. M. , Petriș A. O. , Ungureanu D. A. , Lăcătușu C. M.

Open Medicine

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2014

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tom 10

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nr 1

EN

Cardiovascular risk of prediabetes is still subject to controversies. We analyzed the associations between insulin resistance, adipokines and incipient atherosclerosis estimated by intima-media thickness (IMT) in a cross-sectional study on 122 prediabetic subjects without clinical signs of atherosclerotic disease. Homeostasis model assessment of insulin resistance (HOMA-IR, calculated as fasting insulin × fasting plasma glucose / 22.5), adiponectin, leptin, leptin-to-adiponectin ratio, carotid and femoral IMT were evaluated. We also assessed other parameters related to insulin resistance and adipokines (HbA1c, anthropometric and lipid parameters), as they may also influence atherosclerosis. Carotid IMT was correlated to adiponectin and leptin-to-adiponectin ratio (all p < 0.05), but not with HOMA-IR or leptin, while femoral IMT showed no relationship with these factors. After adjusting for leptin, leptin-to-adiponectin ratio, triglycerides, HDL-cholesterol, cholesterol-to-HDL ratio, triglycerides-to-HDL ratio and HbA1c, IMT values became correlated with HOMA-IR. Adjustment for HOMA-IR induced the appearance of new correlations between adipokines and both IMT values. In conclusion, insulin resistance and adipokines seem related to IMT in prediabetic subjects without clinical signs of arterial obstruction.

2

The relationship between features of metabolic syndrome and blood adipocytokine concentrations in the morbid obese patients during dynamic weight loss

100%

Jankiewicz-Wika J. , Kołomecki K. , Cywiński J. , Piestrzeniewicz K. , Stępień H. , Komorowski J.

Open Medicine

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2006

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tom 1

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nr 2

136-147

EN

Bariatric surgery is the most effective method to achieve weight loss in obese subjects. The aim of this study was to evaluate some adipocytokines and insulin, as well as parameters of metabolic syndrome of the obese patients, for three and six months after vertical banded gastroplasty, in the time of dynamic weight loss. Seven males and two females aged 28 to 49 years, with long lasting simple obesity and the presence of metabolic syndrome, were studied. After surgical treatment the values of the body mass index, waist circumference, systolic and diastolic blood pressure, total cholesterol, LDL cholesterol, triglycerides, and blood concentrations of leptin decreased significantly. Before surgical operation of all obese patients no statistically significant correlations between studied parameters were noted. Three and six months later a lot of correlations between studied parameters appeared. In conclusion, (a) vertical-banded gastroplasty is a valuable method in treatment of obese subjects, leading to a significant decrease in body weight and improvement in some parameters of metabolic syndrome in a few months after surgery, (b) adipocytokines, together with an unknown gastric factor, may be key factors in the control of some features of the metabolic syndrome.

3

Characterization of serum adiponectin and leptin in healthy perinatal dairy cows or cows with ketosis, and their effectson ketosis involved indices

86%

Shen L. , Qian B. , Xiao J. , Zhu Y. , Hussain S. , Deng J. , Peng G. , Zuo Z. , Zou L. , Yu S. , Ma X. , Zhong Z. , Ren Z. , Wang Y. , Liu H. , Zhou Z. , Cai D. , Hu Y. , Zong X. , Cao S. , Shen L. , Qian B. , Xiao J. , Zhu Y. , Hussain S. , Deng J. , Peng G. , Zuo Z. , Zou L. , Yu S. , Ma X. , Zhong Z. , Ren Z. , Wang Y. , Liu H. , Zhou Z. , Cai D. , Hu Y. , Zong X. , Cao S.

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nr 3

4

The associations between the growth hormone/insulin-like growth factor-1 axis, adiponectin, resistin and metabolic profile in children with growth hormone deficiency before and during growth hormone treatment

86%

Witkowska-Sędek E. , Rumińska M. , Stelmaszczyk-Emmel A. , Majcher A. , Pyrżak B.

Acta Biochimica Polonica

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2018

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tom 65

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nr 2

333-340

EN

This study investigated associations between the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis, adiponectin, resistin and metabolic profile in 47 GH-deficient children before and during 12 months of GH treatment. 23 short age-matched children without growth hormone deficiency (GHD) or any genetic or chronic disorders were recruited as controls at baseline. Metabolic evaluation included measurements of adiponectin, resistin, IGF-1, total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, insulin, glycated haemoglobin (HbA1c), thyroid stimulating hormone (TSH) and free thyroxine (free T4) concentrations. The GH-deficient children had significantly higher adiponectin (p<0.05) and total cholesterol (p<0.05) levels, and a significantly lower level of resistin (p<0.05) than the controls. Resistin at 6 months of GH treatment significantly correlated with changes in height SDS in that period (r=0.35) and with the level of fasting insulin (r=0.50), the HOMA-IR (r=0.56) and the QUICKI (r=-0.53) at 12 months of therapy. Adiponectin level at 12 months of GH treatment was significantly associated with changes in HDL-C within the first 6 (r=0.73) and within 12 (r=0.56) months of therapy, while resistin significantly correlated with an increment in IGF-1 within 12 months of treatment (r=0.49) and with total-C at 12 months (r=0.56). Untreated GH-deficient children had higher adiponectin and lower resistin levels than healthy short children without GHD. Adiponectin and resistin levels did not change significantly during the first 12 months of GH therapy. Good responders to GH treatment had a tendency for higher resistin level during GH therapy, which positively correlates with the insulin resistance parameters.

5

The assessment of serum concentration of adiponectin, leptin and serum carbohydrate antigen-19.9 in patients with pancreatic cancer and chronic pancreatitis

72%

Dranka-Bojarowska D. , Lekstan A. , Olakowski M. , Jablonska B. , Lewinski A. , Musialski P. , Sobczyk W. , Kapalka A. , Lampe P.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 5

6

Adiponectin and leptin receptors expression in Barrett's esophagus and normal squamous epithelium in realtion to central obesity status

72%

Mokrowiecka A. , Sokolowska M. , Luczak E. , Dudojc M. , Wieczfinska J. , Kacprzak D. , Wierzchniewska-Lawska A. , Pawliczak R. , Malecka-Panas E.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 2

7

A novel pathophysiological-based panel of biomarkers for the diagnosis of nonalcoholic steatohepatitis

72%

Grigorescu M. , Crisan D. , Radu C. , Grigorescu M. D. , Sparchez Z. , Serban A.

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2012

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tom 63

|

nr 4

8

Maternal first trimester parameters in the prediction of excessive fetal growth in pregnant women with metabolic syndrome

72%

Migda M. , Migda M. S. , Migda B. , Wender-Ozegowska E.

Journal of Physiology and Pharmacology

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2017

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tom 68

|

nr 6

9

Modulatory effect of concomitant administration of sitagliptin and vitamin E on inflammatory biomarkers in rats fed with high fat diet: role of adiponectin

72%

Sakr H. F. , Abbas A. M. , Khalil K. , Shata A. M.

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tom 70

|

nr 6

10

Total and high molecular weight adiponectin levels in the rat model of post-myocardial infarction heart failure

72%

Kalisz M. , Baranowska B. , Wolinska-Witort E. , Maczewski M. , Mackiewicz U. , Tulacz D. , Gora M. , Martynska L. , Bik W.

Journal of Physiology and Pharmacology

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2015

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tom 66

|

nr 5

11

Adiponektyna oraz polimorfi zmy genu apM1 a występowanie nadwagi i otyłości u pacjentów zgłaszających się do poradni ogólnej POZ

72%

Gola M. , Grzeszczak W.

Annales Academiae Medicae Silesiensis

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2012

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tom 66

|

nr 6

27-36

EN

AIM The primary objective of the study, which is the basis of this thesis, was to evaluate the potential association between selected apM1 polymorphisms and the plasmatic concentrations of adiponectin and the incidence of overweight and obesity in the population of patients visiting general outpatient clinics of primary medical care. MATERIAL AND METHODS The reported study comprised a total of 510 adult patients (287 men and 223 women) from the region of southern Poland, who had subsequently sought medical counselling at a general outpatient clinic of primary care. The examined subjects were divided into three (3) groups, following waist circumference values. The control group consisted of patients with a waist circumference <94 cm for men and <80 cm for women. All the subjects had fasting serum concentrations of glucose, insulin, total cholesterol, HDL/LDL fractions, triglycerides, creatinine and adiponectin and genotyping of Y111H (rs17366743), +45 T>G (rs2241766) and +276 G>T (rs1501299) polymorphisms of the adiponectin gene. RESULTS The serum glucose and insulin concentrations in the overweight and obese subjects were statistically signifi cantly higher vs. those in the control group (p < 0.001). The serum adiponectin concentrations in the obese patients were signifi cantly lower vs. those in the overweight subjects (p < 0.001) or those without any excess weight (p < 0.001). Signifi cantly higher values of the HOMA-IR factor were found in both the obese and the overweight patients (p for correlation between either group < 0.01). A strong correlation was observed between the waist circumference and adiponectin levels. It was demonstrated that the adiponectin concentration in the blood decreased with a waist circumference increase (p < 0.001). A similarly strong correlation was noted between the adiponectin levels and BMI (body mass index) values (p < 0.001). The MAF values for the Y111H, +45 T/G and +276 G/T polymorphisms were 0.017, 0.098 and 0.287, respectively. No statistically signifi cant diff erences were demonstrated in the distribution of genotypes between the studied groups for the apM1 Y111H (chi2 = 2.61; p = 0.2706), apM1 +45 T/G (chi2 = 2.10; p = 0.7179) and apM1 +276 G/T (chi2 = 7.93; p = 0.0941) polymorphisms. However, statistically signifi cant diff erences were visualised in the distribution of alleles for the apM1 +276 G/T (chi2 = 6.10; p < 0.05) polymorphism. CONCLUSIONS The results of the reported study confi rm the existence of a strong, negative correlation between the adiponectin levels in the blood and waist circumference or BMI values, also described in a number of literature reports. 2. The apM1 Y111H, +45 T/G and +276 G/T polymorphisms, and in particular the fi rst one, are very rarely found in the Polish population. 3. No correlation was demonstrated between the studied polymorphisms and the incidence of overweight and obesity and serum adiponectin concentration. 4. In the population of subjects with an average GFR = 81.53 ml/min/1.73 m2, the adiponectin concentration positively correlates with glomerular fi ltration values.

PL

CEL PRACY Głównym celem niniejszej pracy była ocena potencjalnego związku między wybranymi polimorfizmami genu apM1 oraz osoczowym stężeniem adiponektyny a występowaniem nadwagi i otyłości w populacji pacjentów zgłaszających się do poradni ogólnej podstawowej opieki zdrowotnej (POZ). MATERIAŁ I METODY Badaniem objęto łącznie 510 dorosłych pacjentów (287 mężczyzn i 223 kobiety) z rejonu Polski Południowej, którzy kolejno zgłaszali się do poradni ogólnej POZ. Badanych podzielono na 3 grupy, zależnie od wartości obwodu pasa. Grupę kontrolną stanowili pacjenci z obwodem talii < 94 cm (mężczyźni) oraz < 80 cm (kobiety). U wszystkich osób oznaczano na czczo w surowicy stężenia glukozy, insuliny, cholesterolu całkowitego, frakcji HDL i LDL, triglicerydów, kreatyniny oraz adiponektyny oraz określono polimorfizmy Y111H (rs17366743), +45 T > G (rs2241766) oraz +276 G > T (rs1501299) genu adiponektyny. WYNIKI W surowicy osób z nadwagą i otyłych stwierdzono istotnie statystycznie wyższe stężenia glukozy i insuliny w stosunku do osób z grupy kontrolnej (p < 0,001). Stężenia adiponektyny w surowicy pacjentów otyłych były istotnie niższe niż u osób z nadwagą (p < 0,001) oraz bez nadwagi (p < 0,001). Zarówno u osób otyłych, jak i z nadwagą stwierdzono znamiennie wyższe wartości wskaźnika insulinooporności HOMA-IR (p dla korelacji pomiędzy każdą z grup < 0,01). Wykazano, że stężenie adiponektyny we krwi maleje wraz ze wzrostem obwodu talii (p < 0,001). Podobnie silną korelację odnotowano między poziomem adiponektyny a wartościami wskaźnika BMI (p < 0,001). Wartości MAF dla polimorfizmów Y111H, +45 T/G oraz +276 G/T wynosiły odpowiednio: 0,017, 0,098 oraz 0,287. Nie wykazano istotnych statystycznie różnic w rozkładzie badanych genotypów między badanymi grupami dla polimorfizmu apM1 Y111H (chi2 = 2,61; p = 0,2706), apM1 +45 T/G (chi2 = 2,10; p = 0,7179) oraz apM1 +276 G/T (chi2 = 7,93; p = 0,0941). Uwidoczniono jednak istotne statystycznie różnice w rozkładzie alleli dla polimorfizmu apM1 +276 G/T (chi2 = 6,10; p < 0,05). Rozkład alleli i genotypów dla polimorfizmów Y111H oraz +45 T/G nie pozwalał na przeprowadzenie wiarygodnych analiz statystycznych. WNIOSKI 1. U badanych z nadwagą i otyłością występuje ujemna korelacja między obwodem talii a stężeniem adiponektyny. 2. Wykazano jednak istotne statystycznie różnice w rozkładzie alleli dla polimorfizmu apM1 +276 G/T pomiędzy badanymi grupami. 3. Nie wykazano zależności pomiędzy występowaniem poszczególnych polimorfizmów a stężeniem adiponektyny w surowicy. 4. Stężenie adiponektyny we krwi koreluje ujemnie z insulinemią i insulinoopornością oraz dodatnio z wielkością filtracji kłębuszkowej.

12

Adiponektyna i leptyna a udar niedokrwienny mózgu

72%

Pyzik M. , Karp-Majewska A.

Aktualności Neurologiczne

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2008

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tom 8

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nr 2

84-89

EN

Abdominal obesity becomes very significant health’s problem, especially because it is connected with pathogenesis of cardiovascular diseases. Adipose tissue is not only a store of excess energy but a hormonally active system too. The substances produced by adipose tissue are adipocytokines. Two of them are leptin and adiponectin. Adiponectin levels are inversely related to the adiposity degree, despite of adipose tissue is only source of it. concentrations of adiponectin have been reported to be decreased in patients with coronary artery diseases, type II diabetes mellitus, hypertensions and dyslipidemia patients in some insulin resistant states. It takes part in processes regulate glucose and lipid metabolism and it has anti-inflammatory and antiatherogenic properties. Adiponectin has a potential protective ability towards to cardiovascular diseases. Positive correlation with degree of adiposity has been reported for leptin – hormone involved in the regulation of food intake and energy expenditure. Leptin exerts many potentially atherogenic effects. It has been reported to influence on arterial hypertension, endothelial dysfunction, platelet aggregation, insulin resistant and activation of sympathetic system. In this way it can play very important role in development of stroke. Recent studies suggest that adiponectin and leptin may play an important role in obesity-associated cerebrovascular diseases. There is still too little evidence to say that these two hormones are independent marks of ischemic stroke and confirm their role in stroke pathogenesis.

PL

Otyłość brzuszna staje się coraz istotniejszym problemem zdrowotnym, głównie ze względu na związaną z nią koincydencję rozwoju chorób sercowo-naczyniowych. Tkanka tłuszczowa jest nie tylko źródłem zapasów energii, ale również hormonalnie czynnym systemem. Substancje wydzielane przez komórki tkanki tłuszczowej to adipocytokiny, do których zaliczamy między innymi leptynę i adiponektynę. Pomimo iż tkanka tłuszczowa jest jedynym źródłem adiponektyny, paradoksalnie jej stężenie w otyłości ulega obniżeniu. Ponadto niższe stężenia wykazano u chorych z chorobą niedokrwienną serca, cukrzycą typu II, nadciśnieniem tętniczym i dyslipidemią, czyli w stanach prawdopodobnej insulinooporności. Adiponektyna bierze udział w procesach usprawniających metabolizm glukozy i lipidów oraz wykazuje działanie przeciwzapalne i przeciwmiażdżycowe, a więc i potencjalnie ochronne działanie wobec chorób sercowo-naczyniowych. Ze wzrostem zgromadzonej tkanki tłuszczowej pozytywnie koreluje poziom leptyny, hormonu uczestniczącego w regulacji poboru pożywienia i wykorzystania energii. Leptyna wykazuje wiele potencjalnie proaterogennych właściwości. Poprzez między innymi wpływ na ciśnienie krwi, układ fibrynolityczny, funkcje śródbłonka, agregację płytek, oporność na insulinę oraz aktywację układu sympatycznego może odgrywać istotną rolę w rozwoju niedokrwiennego udaru mózgu. Badania sugerują, że adiponektyna i leptyna mogą stanowić ogniwo łączące otyłość z chorobami naczyniowymi OUN. Wciąż jednak istnieje zbyt mało danych, by uznać oba hormony za niezależne markery wystąpienia udaru niedokrwiennego mózgu oraz potwierdzić ich rolę w jego patogenezie.

13

Assessment of leptin-to-adiponectin ratio in prediction of insulin resistance and nutrition status in a geriatric female population

72%

Biercewicz M. , Slusarz R. , Kedziora-Kornatowska K. , Filipska K. , Bielawski K. , Ruszkowska-Ciastek B.

Journal of Physiology and Pharmacology

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2020

|

tom 71

|

nr 1

14

Decreased serum adiponectin reflects low vitamin D, high interleukin 6, and poor physical performance in knee osteoarthritis

72%

Udomsinprasert W. , Manoy P. , Yuktanandana P. , Tanavalee A. , Anomasiri W. , Honsawek S.

Archivum Immunologiae et Therapiae Experimentalis

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2020

|

tom 68

|

nr 3

15

Adiponectin, resistin and subclinical inflammation - the metabolic burden in Launois Bensaude syndrome, a rare form of obesity

72%

Harsch I. A. , Bergmann T. , Koebnick C. , Wiedmann R. , Ruderich F. , Hahn E. G. , Konturek P. C.

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2007

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tom 58

|

nr 1

65-76

16

Expression of leptin, NGF and adiponectin in metabolic syndrome

72%

Atanassova P. , Hrischev P. , Orbetzova M. , Nikolov P. , Nikolova J. , Georgieva E.

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2014

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tom 62

|

nr 4

17

Neuroendocrine control of metabolic homeostasis in Polish centenarians

72%

Baranowska B. , Bik W. , Baranowska-Bik A. , Wolinska-Witort E. , Szybinska A. , Martynska L. , Chmielowska M.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

|

nr 6

55-61

EN

Neuropeptides play a pivotal role in the control of metabolic homeostasis. We aimed to evaluate the release of neuropeptides involved in the control of energy homeostasis in relation to metabolic status in aging humans. The study group consisted of 183 women: 75 centenarians (above 100 yrs old), 26 elderly women (below 70 yrs), 45 younger women (mean 26 yrs) and 37 obese women (mean 41.6 yrs). Fasting plasma concentration of leptin, adiponectin, ghrelin active, neuropeptide Y (NPY) and insulin were measured. Our results showed several differences in the metabolic and neurohormonal status in the centenarian group. The incidence of hypertension, glucose intolerance, insulin resistance and dyslipidemia was lower compared with obese women. Leptin and NPY concentrations were significantly lower than in elderly and obese subjects. Moreover, NPY level was higher than that in the younger group. Plasma adiponectin values were higher than in any of the other group. Insulin levels were significantly lower compared with the young and obese groups. Furthermore, a negative correlation was found between adiponectin and HOMA-IR, and adiponectin and insulin. Ghrelin active concentrations were significantly lower compared with the young subjects. However, ghrelin levels were higher than in obese subjects. We conclude that altered neuropeptide activity in centenarians may play a role in the mechanisms contributing to prolonged survival.

18

Serum betatrophin and irisin levels in hepatocellular carcinoma

72%

Pazgan-Simon M. , Zuwala-Jagiello J. , Menzyk T. , Bator M. , Derra A. , Lekstan A. , Grzebyk E. , Simon K. , Kukla M.

Journal of Physiology and Pharmacology

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2020

|

tom 71

|

nr 1

19

Effect of diet and other factors on serum adiponectin concentrations in patients with type 2 diabetes

72%

Ostrowska L. , Fiedorczuk J. , Adamska E.

Roczniki Państwowego Zakładu Higieny

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2013

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tom 64

|

nr 1

EN

Background. Adiponectin is a protein specific to visceral adipose tissue where its concentrations are reduced in type 2 diabetes and obesity. Many factors also determine serum levels of adiponectin such as gender, BMI, as well as diet. Objective. To compare the effects of consuming certain key foodstuff products on serum adiponectin concentrations between diabetic patients and suitable controls. Material and methods. A survey and laboratory testing was performed on 72 patients of whom (n = 21) were diabetics, whilst the control group, (n = 51) non-diabetics. Eating habits were assessed and serum adiponectin was measured in all cases. Results. Diabetic patients had significantly lower adiponectin levels compared to the control group; respectively (23.5±21.1 μg/ml vs. 36.5±21.1 μg/ml; p=0.02). Furthermore, women had higher concentration than men; respectively (41.3 μg/ml± 20.1 μg/ml vs. 22.0 μg/ml± 14.8 μg/ml; p=0.000). A high consumption of foodstuffs such as vegetables, vegetable oils, coffee and tea positively correlated with adiponectin concentration in serum, whilst a negative correlation was seen with consumptions of mixed bread, fried and baked dishes, alcohol, nuts and seeds. Conclusions. Serum adiponectin levels are related to factors such as gender, (higher in women), BMI, (higher in persons with normal body weight) and whether diabetic, (lower in people with diabetes). Multiple correlations were observed between the consumption of foodstuff product groups and serum adiponectin concentration. It is thereby suggested, that adiponectin could have a significant role to play in the treatment and prevention of diabetes and obesity.

PL

Wprowadzenie. Adiponektyna jest białkiem swoistym dla tkanki tłuszczowej wisceralnej. Zmniejszone jej stężenie obserwuje się w cukrzycy typu 2 oraz otyłości. Istnieje wiele czynników determinujących poziom adiponektyny w surowicy krwi tj. płeć, BMI, ale również dieta. Celem pracy była ocena wpływu spożywanych grup produktów na poziom adiponektyny w surowicy krwi osób z cukrzycą oraz grupy kontrolnej. Materiał i metody. Badaniem ankietowym oraz analizą laboratoryjną objęto 72 pacjentów. Grupę badaną (n=21 osób) stanowiły osoby chore na cukrzycę, natomiast grupę kontrolną (n=51 osób) stanowiły osoby bez cukrzycy. Ocenie poddano sposób żywienia oraz zawartość adiponektyny w surowicy krwi pacjentów. Wyniki. Adiponektyna osiągała niższe wartości u osób z cukrzycą w porównaniu do grupy kontrolnej (23,5±21,1 μg/ml vs. 36,5±21,1 μg/ml; p=0,02). Kobiety charakteryzowały się wyższym jej stężeniem w stosunku do mężczyzn (41,3 μg/ml± 20,1 μg/ml vs. 22,0 μg/ml± 14,8 μg/ml; p=0,000). Wysoka częstość spożycia produktów spożywczych takich jak: warzywa, oleje roślinne, kawa i herbata dodatnio korelowała ze stężeniem adiponektyny w surowicy krwi. Natomiast spożywanie pieczywa mieszanego, potraw smażonych i pieczonych, alkoholu, orzechów i pestek było ujemnie skorelowane ze stężeniem adiponektyny w surowicy krwi. Wnioski. Wykazano, że poziom adiponektyny w surowicy krwi zależy od czynników takich jak: płeć (wyższy u kobiet), BMI (wyższy u osób z prawidłową masą ciała) oraz obecności cukrzycy (niższy u osób z cukrzycą). Zaobserwowano wiele korelacji dotyczących częstości spożycia produktów, a stężeniem adiponektyny w surowicy krwi, co też może odgrywać znaczącą rolę w leczeniu oraz profilaktyce cukrzycy oraz otyłości.

20

Short term 13-cis-retinoic acid treatment at therapeutic doses elevates expression of leptin, GLUT4, PPARgamma and aP2 in rat adipose tissue

58%

Krskova-Tybitanclova K. , Macejova D. , Brtko J. , Baculikova M. , Krizanova O. , Zorad S.

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tom 59

|

nr 4

731-743

EN

Temporary defects in the plasma lipid and glucose homeostasis are frequent complication accompanying chronic treatment with 13-cis-retinoic acid (13cRA). White adipose tissue acts as an endocrine organ producing a variety of hormones (adipocytokines) including leptin, adiponectin, tumor-necrosis factor alpha (TNF) and angiotensin II (Ang II), which influence lipid metabolism, systemic insulin sensitivity and inflammation. To study the effect of a short-term 13cRA administration on metabolism of epididymal fat tissue, we treated Wistar rats with five identical therapeutic doses of 13cRA (0.8 mg/kg b.w.) by gavage during a period of 10 days. Expression of adiponectin, leptin, TNF and selected proteins such as adipocyte fatty acid binding protein (aP2), insulin-dependent glucose transporter GLUT4, peroxisome proliferator-activated receptor gamma (PPAR) and retinoid X receptors (RXRs) was investigated using RT-PCR. Short-term treatment with therapeutic doses of 13cRA caused significant increase of the aP2, PPAR and moderately RXR gene expression. Similarly, the relative amount of mRNA for leptin and GLUT4 was increased, while the TNF transcript was decreased after treatment with 13cRA. The gene expression and plasma concentration of adiponectin were without any significant changes. Since local adipose renin-angiotensin system (RAS) has been presumed to be involved in the regulation of fat tissue metabolism, we also investigated the gene expression of RAS components in epididymal fat depot. Our data has shown that 13cRA elevated Ang II receptor type 1 (AT1 receptor) - at both, mRNA and protein level. Thus, our results demonstrate that short-term 13cRA treatment is inducing alterations in fat tissue metabolism in relation to stimulated adipogenesis.