Wyniki wyszukiwania - Biblioteka Nauki

1

N4-Amino-acid derivatives of 6-azacytidine: Structure-activity relationship.

100%

Alexeeva I. , Palchikovskaya L. , Shalamay A. , Nosach L. , Zhovnovataya V. , Povnitsa O. , Dyachenko N.

Acta Biochimica Polonica

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2000

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tom 47

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nr 1

95-101

EN

Several N4-derivatives of 6-azacytidine were synthesized using of Vorbrüggen's condensation method. Their antiviral activity with respect to the adenovirus serotypes 2 and 5 in Hep-2 cells culture was studied and primary specific activity was determined. Correlation between chemical structure of new 6-azacytidine derivatives and their biological properties is discussed.

2

Inhibition of proteolytic processing of adenoviral proteins by ε-aminocaproic acid and ambenum in adenovirus-infected cells

100%

Nosach L. , Dyachenko N. , Zhovnovataya V. , Lozinskiy M. , Lozitsky V.

Acta Biochimica Polonica

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2002

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tom 49

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nr 4

1005-1012

EN

Maturation of adenovirus particles is markedly affected by proteolytic processing. The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs ε-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells infected with adenovirus. Proteolytic processing may be regarded as one of the targets for inhibiting adenovirus reproduction.

3

In vitro immune evaluation of adenoviral vector-based platform for infectious diseases

75%

Baran J. , Kuryk L. , Szczepinska T. , Lazniewski M. , Garofalo M. , Mazurkiewicz-Pisarek A. , Mikiewicz D. , Mazurkiewicz A. , Trzaskowski M. , Wieczorek M. , Pancer K. , Hallmann E. , Brydak L. , Plewczynski D. , Ciach T. , Mierzejewska J. , Staniszewska M.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2023

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tom 104

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nr 4

4

Virus-like particles as vaccine

75%

Chroboczek J. , Szurgot I. , Szolajska E.

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2014

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tom 61

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nr 3

5

Helper-dependent adenoviral vectors in experimental gene therapy

75%

Jozkowicz A. , Dulak J.

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nr 3

EN

In the majority of potential applications gene therapy will require an effective transfer of a transgene in vivo resulting in high-level and long-term transgene expression, all in the absence of significant toxicity or inflammatory responses. The most efficient vehicles for delivery of foreign genes to the target tissues are modified adenoviruses. Adenoviral vectors of the first generation, despite the high infection efficacy, have an essential drawback: they induce strong immune response, which leads to short term expression of the transgene, and limits their usefulness in clinical trials. In contrast, helper-dependent adenoviral vectors (HdAd) lacking all viral coding sequences display only minimal immunogenicity and negligible side-effects, allowing for long-term transgene expression. Thus, HdAd vehicles have become the carrier of choice for adenoviral vector-mediated experimental gene therapy, effectively used in animal models for delivery of transgenes into the liver, skeletal muscle, myocardium or brain. Strong and long-lasting expression of therapeutic genes has allowed for successful treatment of dyslipidemias, muscular dystrophy, obesity, hemophilia, and diabetes. Additionally, the large cloning capacity of HdAd, up to 37 kb, facilitates the use of physiologically regulated, endogenous promoters, instead of artificial viral promoter sequences. This enables also generation of the single vectors expressing multiple genes, which can be potentially useful for treatment of polygenic diseases. In this review we characterize the basic features of HdAd vectors and describe some of their experimental and potential clinical applications.

6

Evaluation of the protective effect of a prime-boost strategy with plasmid DNA followed by recombinant adenovirus expressing BmAMA1 as vaccines against Babesia microti infection in hamster

63%

Wang G. , Yu L. , Efstratiou A. , Moumouni P. F. A. , Liu M. , Guo H. , Gao Y. , Cao S. , Zhou M. , Li J. , Ringo A. E. , Xuan X.

Acta Parasitologica

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2018

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tom 63

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nr 2

7

Incidence and detection of aviadenoviruses of serotypes 1 and 5 in poultry by PCR and duplex PCR

63%

Niczyporuk J. , Samorek-Salamonowicz E. , Czekaj H.

Bulletin of the Veterinary Institute in Puławy

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2010

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tom 54

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nr 4

EN

The aim of the study was to develop and optimise a single PCR and duplex PCR for the detection and differentiation of avian adenovirus serotypes 1 and 5 in poultry. The methods were based on sequence of hexon gene of the serotypes. The PCR and duplex PCR DNA products were 227 pb and 178 bp for serotypes 1 and 5, respectively, and were highly specific. The duplex-PCR method was found to be a highly specific, sensitive, and efficient rapid tool for the detection of serotypes 1 and 5 of adenoviruses, which could be detected in one reaction mixture. During this study, 30 of the isolates obtained from internal organs of healthy birds contained both serotypes of the adenovirus. In the case of six isolates, both serotypes were detected in one bird.

8

N4-amino-acid derivatives of 6-azacytidine: structure - activity relationship

63%

Alexeeva I. , Palchikovskaya L. , Shalamay A. , Nosach L. , Zhovnovataya V. , Povnitsa O. , Dyachenko N.

|

2000

|

tom 47

|

nr 1

EN

Several N4-derivatives of 6-azacytidine were synthesized using of Vorbrueggen's condensation method. Their antiviral activity with respect to the adenovirus serotypes 2 and 5 in Hep-2 cells culture was studied and primary specific activity was determined. Correlation between chemical structure of new 6-azacytidine derivatives and their biological properties is discussed.

9

The role of PTEN in allergic inflammation

63%

Lee Y. C.

Archivum Immunologiae et Therapiae Experimentalis

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2004

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tom 52

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nr 4

10

Production and isolation of adenovirus in fox farms in Western Siberia

63%

Shestopalov A. M. , Durimanov A. G. , Rassadkin Y. N. , Ustinova E. N. , Trapezov O. V.

Zeszyty Naukowe. Przegląd Hodowlany

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1996

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tom 28

11

Characteristics of foodborne viruses – selected data

51%

Niedzwiedzka-Rystwej P. , Deptula W.

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tom 13

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nr 1

12

Disseminated adenovirus disease in immunocompromised patient successfully treated with oral ribavirin: a case report

51%

Ulrych E. E. , Dzieciatkowski T. , Przybylski M. , Zdunczyk D. , Boguradzki P. , Torosian T. , Waszczuk-Gajda A. , Rynans S. , Wroblewska M. , Jedrzejczak W. W. , Mlynarczyk G.

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2011

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tom 59

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nr 6

13

Distemper virus diagnosis in foxes and minks

51%

Shestopalov A. M. , Sazonkin B. N. , Trapezov O. V.

Zeszyty Naukowe. Przegląd Hodowlany

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1996

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tom 28

14

Charakterystyka krajowych izolatow adenowirusa krwotocznego zapalenia jelit [HE] indykow i ocena sytuacji epizootycznej w Polsce

44%

Koncicki A.

Acta Academiae Agriculturae ac Technicae Olstenensis. Veterinaria

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1996

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tom 22,Suppl.F

1-43

PL

Całość badań zrealizowano w dwóch częściach. W pierwszej części pracy - laboratoryjno-eksperymentalnej - scharakteryzowano w zakresie taksonomicznym, patogennym i właściwości immunogennych dwa pierwsze krajowe izolaty wirusa HE. Wykazano, że oba izolaty (HEV1 i HEV2) są identyczne, a pod względem morfologicznym oraz właściwości fizykochemicznych odpowiadają aviadenowirusom grupy II. Wirusy te w warunkach eksperymentalnych nie wywołują u indyków objawów klinicznych, choć powodują zmiany histopatologiczne w wielu narządach. W drugiej - terenowej fazie - prowadzono monitoring serologiczny stad oraz analizowano sytuację epizootyczną pod kątem wpływu zakażeń wirusem HE na zdrowotność indyków oraz efekty produkcyjne. Wykazano, że wirus HE jest szeroko rozpowszechniony, a powodując immunosupresję wywołuje znaczne straty w chowie indyków.

EN

The research was divided into two parts. The first one - including laboratory work and experiments - enabled to characterize two first domestic HEV isolates from the perspective of taxonomy and their patogenie and immunogenic properties. It was shown that both of the examined isolates (HEV1 and HEV2) are identical, and that they correspond to Aviadenovirus of group II as far as their morphological and physico-chemical properties are concerned. Although the virus in question does not cause clinical symptoms in experimental conditions, it produces histopathological changes in several organs of turkeys. The other part of research - the field one - included serological monitoring of flocks and analysis of epizootic situation, taking into account the influence of infections with HEV on the health state of turkeys and production efficiency. It was shown that HEV is widespread and that it causes considerable losses in turkey rearing by bringing about immunosuppression.