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1 Polish Journal of Environmental Studies

1 1995

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The constituents of hepatic and placental mixed function oxidase [MFO] systems after acute carbon tetrachloride intoxication

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Bienioszek M. , Plewka A. , Chmielarska-Kotus K. , Pajak J.

Polish Journal of Environmental Studies

1995

tom 04

nr 2

The influence of acute carbon tetrachloride intoxication on hepatic and placental cytochrome P-450 content, and on NADPH-cytochrome P-450 reductase was examined in Wistar female rats. The animals were pretreated with a single dose of CC14 before pregnancy. The contents of the constituents of the MFO system were measured at term. The results revealed that the CCl4-mediated decrease at the total hepatic cytochrome P-450 level was reduced by pregnancy. Carbon tetrachloride pretreatment did not change the placental cytochrome P-450 level. A significant increase in placental microsomal cytochrome P-450 reductase activity was found after acute CC14 intoxication, which did not influence this enzyme in the liver of pregnant individuals.