Wyniki wyszukiwania - Biblioteka Nauki

1

CFD simulations of blood flow through abdominal part of aorta

100%

Polanczyk A. , Piechota A.

Challenges of Modern Technology

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2010

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tom Vol. 1, no. 1

34--39

EN

The aim of this research was to show superiority of using real geometries in simulations of blood fl ow through cardiovascular system. Our model compared blood fl ow through an abdominal part of aorta reconstructed with a use of data from an AngioTK research with the 3DDoctor software to geometries with the same diameters at inlet and outlet as mention before but created only with the Gambit 2.2.30 software without data from AngioTK. Blood fl ow simulations were prepared with the Fluent 6.2.16 software. Calculations of fl ow through a real geometry allows to obtain realistic results of values connected with process of blood fl ow. Results showed that calculations blood fl ow through a virtual geometry lasted two times longer than for a real geometry. Mesh for a real geometry consist about 600.000 elements and for a virtual geometry about 900.000 elements. Wall shear stress and blood velocity was higher for a real geometry and closer to that in human organism. It was shown that calculating a virtual geometry vessel was to big simplifi cation when investigating blood fl ow through a vessel. Application of mathematical models based on real geometries gives more realistic results than artifi cial geometries. Virtual models have lots of simplifi cations which results are far away from expectations. Simplifi cations depend on the model that is used.

2

The clinical relevance of coeliac trunk variations

86%

Gielecki J. , Zurada A. , Sonpal N. , Jablonska B.

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tom 64

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nr 3

123-129

EN

The coeliac trunk is a surgically significant artery originating from the abdominal aorta and supplying the supracolic organs. Branches of this arterial trunk supply the primary organs of the abdomen and divert a significant volume of blood from the abdominal aorta. Past research has shown that the anatomy of the coeliac trunk is not identical for all human beings and that about 15% of the population displays significant variations from the typical branching pattern. Data derived from earlier research has been consolidated to give an account of the major variations found in the anatomy of the coeliac trunk and to put forward some theories for the cause of such variation. It is crucial to achieve full comprehension of these topics as knowledge of these variations is indispensable in operative and diagnostic procedures within the abdomen. Without understanding of the arterial architecture and knowledge of the variation characterising the patient in this critical region surgery may entail a considerable risk of an error being committed that may occasionally lead to lethal complications.

3

Analiza porównawcza składu pierwiastkowego ścian aorty brzusznej i tętniaka aorty brzusznej

86%

Kobielarz M. , Marycz K. , Szotek S. , Będziński R.

Engineering of Biomaterials

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2009

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tom Vol. 12, no. 89-91

185--187

PL

Głównym celem pracy było określenie procentowego składu pierwiastkowego ścian zdrowej aorty brzusznej (NAA) i tętniaka aorty brzusznej (AAA) na podstawie mikroanalizy rentgenowskiej (Rtg) dla dużej populacji materiału badawczego, ażeby sprawdzić użyteczność metody do różnicowania (na poziomie molekularnym) materiału biologicznego pod kątem zmian chorobowych. Dla żadnego z analizowanych pierwiastków nie odnotowano, na poziomie istotności p=0,05, istotnych statystycznie zmian w procentowym rozkładzie pierwiastków między preparatami ścian zdrowych aort brzusznych oraz tętniaków. Na podstawie uzyskanych wyników wykazano, biorąc pod uwagę wielkość grup badawczych, że zastosowana metoda nie umożliwia różnicowania materiału biologicznego na założonym poziomie istotności.

EN

The main aim of paper was evaluation of chemical elements composition of normal abdominal aortic walls (NAA) and abdominal aortic aneurysms walls (AAA) based on X-ray microanalysis for a numerous and diversified population in order to differentiate (on molecular level) biological materials according pathological changes. For neither of analyzed elements were noticed statistically significant on the confidence level p=0,05 differences between NAA walls and AAA walls. On the basis of the obtained results it can be concluded that used methods isn’t sufficient to differentiation of biological materials according pathological changes.

4

Elastin and collagen fibres alterations for abdominal aortic aneurysms population with constant maximum diameter size

86%

Kobielarz M. , Maksymowicz K. , Będziński R.

Engineering of Biomaterials

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2011

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tom Vol. 14, no. 102

2--6

EN

Development of abdominal aortic aneurysm (AAA) is a dynamic process proceeding as a result of the multi-factor pathological remodelling of elastin and collagen fibres, results an aneurysm expansion. In clinical practice, development of AAA is identified with aneurysm growth. Hence, the aim of this paper is to propose a taxonomy of load-bearing structural components alterations for AAA with relatively constant maximum diameter (average diameter 6.9±0.8 cm). Structural investigations of normal (n=47) and aneurismal (n=46) vessels were carried out on the basis of histological and ultrastructural examinations. The histological preparations were subjected to histometric evaluation; the number of collagen and elastin fibres and additionally the thickness of the particular vascular wall layers. A qualitative analysis of the abdominal aortic wall, mainly estimation of fibres arrangement, based on histological and ultrastructural (SEM) examinations were additionally performed. Using a cluster analysis, three stages of load-bearing fibres alterations for AAA population were distinguished. The clusters were systematized according to NAA results. For AAA population with relatively constant maximum diameter in the first stage of load-bearing fibres remodeling was observed a substantial loss of elastin fibres. The second stage is characterized by an increase in the number of collagen fibres. In the final stage the number of collagen is dramatically reduced. Presented results provide evidence to risk of AAA rupture is not connected with AAA size but a remodelling of extra-cellular matrix proteins. The remodelling is accompanied by changes in the AAA wall thickness, which should be taken into consideration when evaluating the degree of advancement of this disease.

5

Effect of triiodothyronine on phospholipid metabolism in skeletal muscles of the rat

86%

Zendzian-Piotrowska M. , Gorska M. , Dworakowski W. , Gorski J.

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nr 1

6

Types of renal arteries in aspect of the reconstruction operation of the abdominal aorta

86%

Kucznik W. , Mikusek J. , Kaletka Z. , Ziaja K.

Folia Morphologica

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1996

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tom 55

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nr 4

7

Variation in the arteries of the aortic arch in European brown hare [Lepus europaeus]

72%

Brudnicki W. , Macherzynska A. , Nowicki W.

Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine

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2007

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tom 10

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nr 1

8

Variation in branches of the abdominal aorta in European rabbit

72%

Nowicki W. , Brudnicki W. , Iwanczyk M. , Jablonski R. , Skoczylas B.

Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine

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2010

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tom 13

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nr 4

9

Adropin, nesfatin-1 and angiotensin II receptor expression in the abdominal aorta in ovariectomized rats after nesfatin-1 treatment

72%

Pawlowska-Olszewska M. , Puzio I. , Tymicki G. , Kalisz G. , Sroka-Bartnicka A. , Blicharz-Kania A. , Nowakiewicz A. , Kosior-Korzecka U. , Kulak K.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 6

10

Beta-adrenergic antagonists influence abdominal aorta contractility by mechanisms not involving beta-adrenergic receptors

72%

Hauzer W. , Bujok J. , Czerski A. , Rusiecka A. , Pecka E. , Gnus J. , Zawadzki W. , Witkiewicz W.

Folia Biologica

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2014

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tom 62

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nr 3

11

Comparison of the effect of alpha1- and alpha2-adrenoceptor agonists and antagonists on muscle contractility of the rabbit abdominal aorta in vitro

72%

Gnus J. , Rusiecka A. , Czerski A. , Zawadzki W. , Witkiewicz W. , Hauzer W.

Folia Biologica

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2013

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tom 61

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nr 1-2

12

Experimental methods of abdominal aortic aneurysm creation in swine as a large animal model

72%

Czerski A. , Bujok J. , Gnus J. , Hauzer W. , Ratajczak K. , Nowak M. , Janeczek M. , Zawadzki W. , Witkiewicz W. , Rusiecka A.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 2

13

Morphology and development of the terminal portion of the abdominal aorta in cow during fetal and neonatal periods

72%

Molenda O. , Radek J. , Radek T.

Folia Morphologica

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1990

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tom 49

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nr 1-2

14

Ocena histologiczna i ultrastrukturalna ścian tętniaków aorty brzusznej

72%

Kobielarz M. , Maksymowicz K. , Kaleta K. , Kuropka P. , Marycz K. , Będziński R.

Engineering of Biomaterials

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2010

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tom Vol. 13, no. 99-101

83--87

PL

Rozwój tętniaków, w tym aorty brzusznej (AAA) jest dynamicznym procesem, który zachodzi w wyniku wieloczynnikowego, patologicznego remodelingu tkanki łącznej ściany aorty. Badania strukturalne ścian naczyń tętniczych (zdrowych i z tętniakiem) przeprowadzono w oparciu o analizę histologiczną i ultrastrukturalną. Analiza porównawcza wyników wykazała, że w przypadku preparatów ścian tętniaków aorty brzusznej odnotowano cały szereg zmian, które są charakterystyczne dla rozważanego schorzenia, w tym: wzmożony proces neowaskularyzacji oraz obecność nacieku zapalnego. Ponadto, odnotowano zatarcie granic między warstwami oraz redukcję ich grubości, co szczególnie zaznaczyło się w przypadku błony wewnętrznej. Zaobserwowano istotny ubytek włókien elastynowych oraz zmienny co do intensywności w poszczególnych przypadkach ubytek włókien kolagenowych. Wykazano także, że zmiany w liczbie włókien tkanki łącznej odgrywają kluczową rolę w procesie rozwoju AAA.

EN

The development of abdominal aortic aneurysm (AAA) is a dynamic process proceeding as a result of the multi-factor pathological remodelling of the connective tissue. Structural investigations of normal and aneurismal vessels were carried out on the basis of histological and ultrastructural examinations. A comparative analysis of the experimental results revealed a whole series of changes characteristic of the AAA walls (intensified neovascularisation and inflammatory infiltrations). In addition, the boundaries between the layers were found to be blurred and the thickness of the layers was reduced. A substantial loss of elastin fibres and a case-specific loss of collagen fibres were observed. The number of connective tissue fibres play a key role in the AAA development.

15

Farnesoid X receptor regulates vascular reactivity through nitric oxide mechanism

72%

Zhang R. , Ran H.-H. , Zhang Y.-X. , Liu P. , Lu C.-Y. , Xu Q. , Huang Y.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 4

16

Effect of heavy metal cations on the activity of cathepsin D (in vitro study)

72%

Karwowska A. , Lapinski R. , Gacko M. , Grzegorczyk E. , Zurawska J. , Karczewski J. K.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 3

17

Nitric oxide decreases renal medullary Naplus, Kplus-ATPase activity through cyclic GMP-protein kinase G dependent mechanism

72%

Beltowski J. , Marciniak A. , Wojcicka G. , Gorny D.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 2

EN

The aim of this study was to investigate the effect of nitric oxide on renal Na+,K+-ATPase and ouabain-sensitive H+,K+-ATPase activities. The study was performed in male Wistar rats. The investigated substances were infused under general anaesthesia into abdominal aorta proximally to the renal arteries. The activity of ATPases was assayed in isolated microsomal fraction. NO donor, S-nitroso-N-acetylpenicillamine (SNAP), infused at doses of 10-7 and 10-6 mol/kg/min decreased medullary Na+,K+-ATPase activity by 29.4% and 45.2%, respectively. Another NO donor, spermine NONOate, administered at the same doses reduced Na+,K+-ATPase activity in the renal medulla by 31.7% and 46.5%, respectively. Neither of NO releasers had any effect on Na+,K+-ATPase in the renal cortex and on either cortical or medullary ouabain-sensitive H+,K+-ATPase. Infusion of NO precursor, L-arginine (100 µmol/kg/min), decreased medullary Na+,K+-ATPase activity by 32.2%, whereas inhibitor of nitric oxide synthase, L-NAME (10 nmol/kg/min), increased this activity by 20.7%. The effect of synthetic NO donors was mimicked by 8-bromo-cGMP and blocked by inhibitors of soluble guanylate cyclase, ODQ or methylene blue, as well as by specific inhibitor of protein kinase G, KT5823. In addition, inhibitory effect of either SNAP or 8-bromo-cGMP on medullary Na+,K+-ATPase was abolished by 17-octadecynoic acid (17-ODYA), which inhibits cytochrome P450-dependent metabolism of arachidonic acid. These data suggest that NO decreases Na+,K+-ATPase activity in the renal medulla through the mechanism involving cGMP, protein kinase G, and cytochrome P450-dependent arachidonate metabolites. In contrast, NO has no effect on Na+,K+-ATPase in the renal cortex and on either cortical or medullary ouabain-sensitive H+,K+-ATPase.

18

Lack of ovarian response in ageing cows to noradrenaline infused into the abdominal aorta

72%

Kotwica J. , Jaroszewski J. , Bogacki M.

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nr 4

EN

A cannula was inserted into the aorta abdominalis through the coccygeal artery (cranial to the origin of the ovarian artery) in mature heifers (n=4) and in old cows (n=4) with reproductive disorders, to facilitate infusion of noradrenaline (NA; 4 mg/30 min) on day 10 of the oestrous cycle. Before, during and after NA jnfusion peripheral blood samples were collected for progesterone and oxytocin determination every 5-10 min. Each NA infusion stimulated (P < 0.01) secretion of both hormones in mature heifers. However, there were no hormonal response to NA treatment in ageing cows. In conclusion we assume that: (a) lack of ovary response to noradrenergic stimulation is involved in the reproductive disorders in the cow or (b) an ovary with disordered function does not respond to NA treatment, perhaps due to impairment of ß-adrenergic signalling system.

19

Decreased hypotensive responsiveness to nitric oxide donor S-nitroso N-acetyl-DL-penicillamine [SNAP] in spontaneously hypertensive [SHR] rats

72%

Stys T. , Stys A. , Paczwa P. , Szczepanska-Sadowska E. , Lipkowski A. W.

Journal of Physiology and Pharmacology

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1998

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tom 49

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nr 1

20

Abdominal aorta anastomosis in rats and stable gastric pentadecapeptide BPC 157, prophylaxis and therapy

58%

Hrelec M. , Klicek R. , Brcic L. , Brcic I. , Cvjetko I. , Seiwerth S. , Sikiric P.

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tom 60

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nr 7