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Molecular basis for the degradation of aromatic xenobiotic compounds

100%

Gren I. , Guzik U. , Wojcieszynska D. , Labuzek S.

Biotechnologia

2008

nr 2

58-67

Aromatic compounds in the environment can be of natural or anthropological origins. Xenobiotic arenes are found to be weakly degraded because of the presence of stable aromatic ring (due to the delocalization of their p orbitals) and different constituents which can impede biodegradation rate. That's why the cleavage of aromatic ring by dioxygenases of bacterial origin is the critical step in removing of theses xenobiotics from environment. Also, monooxygenases play important role in biotransformation of the initial structure to one of the central intermediates: catechol, hydroquinone, protocatechuate or gentisate. In biodegradation of haloaromatics, dehalogenases are the essential enzymes in removing these xenobiotics.

Role of genetically detrmined oxidation of drugs and xenobiotics in pathogenesis of neoplastic diseases

80%

Niewinski P. , Orzechowska-Juzwenko K.

tom 50

nr 4

321-332

The relationship between genetically determined polymorphic hepatic oxidation and susceptibility to neoplastic diseases have aroused much interest. Some studies provide evidence of a possible association between oxidation phenotype, especially extensive and very extensive phenotype, and increased risk of the development of cancers. This work presents modern views on that subject.

Biodegradation and detoxification of xenobiotics and compounds of natural origin

70%

Dlugonski J. , Lisowska K. , Paraszkiewicz K. , Slaba M. , Bernat P.

nr 4

62-68

Microscopic fungi are widely used for synthesis and transformation of biologically active compounds e.g. antibiotics, corticosteroids and androgens. The fungal strains applied for steroid hormone production are also able to attack pollutants, including deleterious xenobiotics e.g. polycyclic aromatic hydrocarbons (PAHs), chlorophenols or organotins to less toxic derivatives. Transformation, detoxification, and degradation of both types of hydrophobic substrates (steroids and xenobiotics), as well as heavy metals recovery from industrial wastes, are in the center of interest of Department of Industrial Microbiology and Biotechnology. This paper is a short review on a possibility of application of industrial strains for environment protection and an introduction to our detailed presentations (1-4) on this subject, during The 2nd National Biotechnology Congress in Lodz.