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Antifungal efficiency of three traditional medicinal plants against Trichophyton rubrum

100%

Kindu G. , Mekonen M. , Ageze E. , Abebaw M. , Workie A. , Getnet B.

World News of Natural Sciences

2019

tom 25

15-21

Cutaneous fungal infection are a wide-spread public health concern affecting millions of people all across the world. Nearly half of the affected will experience multiple episodes of infection requiring numerous rounds of treatment. Trichophyton rubrum was the most common etiological agent of dermatophytes, and it is emerging as an important and significantly prevalent infection in an increasingly aging population and immune-compromised patients. Development of more effective and less toxic anti-fungal agents is required for the treatment of dermatophytosis. The aim of the study was to evaluate the anti-fungal activity of extracts of three plant species used in traditional medicine against Trichophyton rubrum. The ethanol and water extracts of Eucalyptus globules, Croton macrostachyus, and Phytolacca dodecandra leaves were evaluated in vitro for anti-fungal activity against Trichophyton rubrum, using the agar well diffusion technique. The mean inhibition zone of both extracts for E. globulus, C. macrostachyus and P. dodecandra were 19.8, 20 and 16.3 mm, respectively, and mean inhibition zone of the ethanol and water extracts were 23 and 14.4 mm, respectively. Generally, mean inhibition zone of plant extracts did not show statistically significant difference among plants and the mean inhibition zone of plant extracts did show statistically significant difference between extracts (P ≤ 0.05). On the basis of the current findings, Eucalyptus globules and Croton macrostachyus could be good candidates in the search for new antifungal agents from natural products against Trichophyton rubrum. Therefore, further studies are needed to study their toxicology and isolate the bio- active components from these plants.

Anti-dermatophytic activity of garlic (Allium sativum) extracts on some dermatophytic fungi

58%

Mercy K. A. , Ijeoma I. , Emmanuel K. J.

2014

tom 19

Dermatophytic infection is a common infection that constitutes public health problem among children. Anti dermatophytic activity of aqueous, ethanolic and methanolic extracts of garlic (Allium sativum) was investigated against isolates of dermatophytic fungi obtained from sixty primary school children in Aba. The well in agar diffusion technique was used to determine the sensitivity patterns of the test organisms. The results were compared with the activity of a known antifungal drug nystatin. The isolates included Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum gypseum, Trichophyton verrucosum and Epidermophyton floccosum. The result of the antifungal activity of garlic showed high but varied levels of antifungal effectiveness on the different species of the dermatophytes at four different concentrations of 12.5 %, 25 %, 50 % and 100 % used. T. rubrum was the most susceptible followed by M. gypseum, T. mentagrophytes, T. verrucosum and E. floccosum respectivey. The diameter zones of inhibition exhibited by the extracts against test fungal species ranged between 4.50 mm and 30.67 mm. Further purification and extraction of active principle of garlic would give an antidermatophytic activity comparable to standard antifungal drugs.