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Therapeutic strategies for Alzheimer's disease based on new molecular mechanisms

100%

Religa D. , Winblad B.

nr 4

393-396

Background and objective: Alzheimer's disease (AD) ? the main cause of dementia ? is characterized by the presence of neuritic plaques containing the amyloid-beta peptide (A beta) and an intraneuronal accumulation of tubule-associated protein called tau. The current and future therapeutic strategies for AD will be discussed. Currently available treatment used in AD is based on acetylcholinesterase inhibitors, since in the course of AD there is a substantial loss in cholinergic neurons. Another registered drug used in more severe AD is NMDA antagonist ? memantine. Available strategies for AD include vitamin supplementation for reducing homocysteine levels, statins and non-steroidal anti-inflammatory drugs. The big hope of the last few years ? vitamin E and estrogen supplementation have not been proved efficient, but more studies are needed. There are several strategies aimed at acting directly on A beta or amyloid precursor protein (APP) processing: vaccination with A beta peptide, A beta passive immunization, beta and gamma secretases inhibitors. Nerve growth factors and neurotrophines could also be targeted by new therapies. Conclusions: a better understanding of the role of APP processing and folate and homocysteine in neuronal homeostasis throughout life consist revealing novel and relatively inexpensive approaches for preventing and treating AD.

Starozytne postawy wobec powinnosci medycznych

80%

Nowacka M.

Archeus. Studia z bioetyki i antropologii filozoficznej

2011

tom 12

33-54

Rational medicine, i.e. the one which is not an attempt to conciliate forces evil to man, was shaped in Ancient Greece simultaneously with the birth of philosophical thinking. And in its beginning it was indistinguishable from philosophy because any in tellectual activity of man aiming at understanding something was philosophy. Even when within the frames of philosophy particular disciplines – astronomy, physics, biology, and also medicine – started to be aware of their autonomy, they still remained essentially philosophical. Ancient medicine is philosophical medicine because all its ﬁndings are understood in a philosophical context – deep conviction of philosophers that the universe is an orderly, proportional, and harmonic entirety is transmitted from physicians to patients. Such is the source of medical theory, according to which good health is a harmony of elements in human body, as well as subsequent conviction about peculiar isomorphism of macrocosm and microcosm. The only real indicator of autonomy of medicine from philosophy was a necessary element of realism regarding particular human being who was supposed to be eﬀectively aided in his sickness by concrete means. Philosophy did not have to care about reality so philosophy could bend reality to its speculated theories without having to verify them in practice. However, natural empirism of medicine could not inﬂuence philosophy as medicine itself did not possess, and will not possess for a long time, so big scientiﬁc database that it could be an inﬂuencing factor on philosophica settlements. Ethics will become the common ground for mutual relations between medicine and philosophy. And on this ground a particular analogy between treating human body and healing human soul will be settled, an analogy incomparably more useful for philosophy than for medicine.