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A morphologixal study of the testes in relation to acetylcholinesterase actvity in the brain and testis of an organophosphate pesticide ingested by a wild passerine bird (Lonchura malabarica)

100%

Maitra S. , Sarkar R.

Folia Biologica

1995

tom 43

nr 3-4

143-149

Oral administration of an organophosphate pesticide, phosphamidon, at sublethal doses caused a decrease in both and testicular acetylcholinesterase (AChE), paired testicular weight, seminiferous tubular diameter, and the number of tubules containing healthy germ cells in the testes of adult whitetroated munias in a dose and duration depended manner.While no significant changes in the cytomorphology and nuclear diameter of Leyding cells were noted in the testes of the experimental birds, a significant negative correlation was observed between the number of semiferous tubules containing degenerated germ cells and the rate of AChE activity in both the testes and in the brain of respective bird groups.These findings demonstrate for the first time that the antigametogenic effects of an OP pesticide on avian tests may be due to impaired cholinergic functions in the brain and/or the testes in the birds concerned.

Hormonal regulation of oestrogen formation by Leydig cells in vitro: immunocytochemical approach

86%

Gancarczyk M. , Tworzydlo W. , Szlachta A. , Sadowska J. , Bilinska B.

Folia Biologica

2003

tom 51

nr 3-4

181-188

The ability of the testis to convert androgens into oestrogens is related to the presence of a microsomal enzyme, aromatase, in testicular cells. The aim of this study was to show whether the supplementation of culture media with LH or an aromatase inhibitor could affect the process of aromatisation in Leydig cells of the bank vole in vitro. This was investigated by means of immunocytochemistry and radioimmunological assays. In control cultures of Leydig cells, both steroid hormones secretion as well as immunoreactivities for aromatase and oestrogen receptor were weaker than in those treated with LH. On the contrary, the addition of aromatase inhibitor into the culture medium resulted in a decreased intensity of immunocytochemical stainings in comparison with the control. Concomitantly, the androgen level was slightly higher, whereas that of oestrogen significantly lower than in the control cultures. Additionally, to check whether steroid hormones are able to regulate aromatase or oestrogen receptor immunoexpressions, some of the Leydig cell cultures were enriched with testosterone or oestradiol, respectively. Strong immunoreactivities for both aromatase and oestrogen receptor were observed. This suggests that Leydig cells in vitro are able to regulate directly the secretion of oestrogens by active aromatase. Finally, it is concluded that oestrogen formation in bank vole Leydig cells in vitro can be influenced by various factors. It should be stressed, however, that the effect of hormone stimulation or aromatase inhibitor action appeared to be dependent on the length of light cycles that bank voles were exposed prior to the isolation of Leydig cells.