Shigella flexneri outer membrane proteins (OMP) which had been earlier found to exert immunomodulatory effect on cell mediated immune response were also found to act as immunomodulator of the humoral immune response. Effects of OMP were investigated in the experiments in vitro and in vivo, where the level of humoral immune response measured as the number of plaque-forming cells (PFC) to SRBC in the spleen was evaluated. We demnostrate that small doses of OMP stimulate, whereas higher doses suppress the humoral immunity.
Effect of splenocytes isolated from mice immunized with suppressive dose of OMP rfom Shigella on delaed hipersensivity, induced in mice with sheep red blood cells was investigated. Only the population of T lymphocytes was found to suppress the delayed hypersensitivity, as measured by the footpad reaction. The results suggest that OMP of Shigella are able to induce in the spleen of animals active T cells which are responsible for the suppression of cellular response induced by SRBC.
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