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Insilico Studies of activities of compounds from Ricinodendron heudelotii against inflammatory and oxidant enzymes Carbonic anhydrase

100%

Ikezu U. J. M. , Ugariogu S. N.

World News of Natural Sciences

2024

tom 55

119-153

Medicinal plants have been acclaimed and documented over the years to play vital role in promoting human health. The study evaluated the activities of the compounds extracted from the Ricinodendron heudelotii seed against carbonic anhydrase enzyme which is responsible for inflammation and oxidation in the body. In this study, phytocompounds from the seed were extracted and characterized using gas chromatography coupled to a mass selective detector to identify the component phytochemicals responsible for its anti-oxidation and inflammatory activity. Site directed multi-ligand docking of the identified compounds was performance on Crystal structure of human Carbonic anhydrase I in complex with polmacoxib as the cocrystalline ligand with (PDB ID:5gmm). The compounds identified from GCMS results were compared with some standard anti-inflammatory and antioxidant drugs like Diclofenac, Indomethacin, Celecoxib, Naproxen and the cocrystaline ligand Polmacoxib. The docking result showed that the cocrystallized ligand have the best binding affinity of -8.5 kcal/mol followed by Naproxen (drug) -7.6 kcal/mol, phytocompound 1,2-Benzisothiazole, 3-(hexahydro-1H-azepin-1-yl)-, 1,1-dioxide and a commercial drug Celecoxib has the same affinity -7.5 kcal/mol, better than Diclofenac -7.0 kcal/mol, Indomethacin (drug) -6.7 kcal/mol, other phytocompounds like Phenol, 2-methoxy-4-(2-propenyl)-, acetate -6.4 kcal/mol, 1,2-Benzenedicarboxylic acid, bis(2-methylpropyl) ester -6.1 kcal/mol also showed good binding affinities with the protein showing that most of the compounds may have good anti-inflammatory and antioxidant properties there by validating the ethnomedical claims of the plant use as having anti-inflammatory potentials. The interactions of the phytocompounds with better binding affinity were visualized and their results proved that the dockings were done in the active sites with strong bonds. ADMET properties of the drugs, cocrystalline ligand and compounds with good binding affinities were carried out to check for their adsorption, distribution, metabolism, excretion and toxicity properties. The result showed that the compounds and drugs have good absorption, distribution, metabolism with the human body and are not toxic to the body. The research justifies the local claims on the use of the plant and strengthens the relevance of these compounds as promising lead candidates for the treatment of anti-inflammatory diseases.

Susceptibility of Sitophilus zeamais Mots. and Callosobruchus maculatus F. to plant parts of Ricinodendron heudelotii

63%

Epidi T. T. , Udo I. O. , Osakwe J. A.

Journal of Plant Protection Research

2009

tom 49

nr 4

411-415

Studies were carried out in the laboratory to determine the efficacy of powders from plant parts of Ricinodendron heudelotii against the storage pests Sitophilus zeamais and Callosobruchus maculatus on stored maize and cowpea, respectively. Leaf, bark and root powders were added as admixtures to 100 g of grains to assess contact toxicity, damage assessment, progeny production and grain germination. Results indicated that the plant materials were toxic to the two insect species with over 30% and 75% mortality for S. zeamais and C. maculatus, respectively. Observable damage level was significantly (p ≤ 0.05) lower in treated grains while progeny production by both insect species was significantly (p ≤ 0.05) reduced. Grain germination of both crops was not affected by the powders. The potential use of P. heudelotii in storage pest management is discussed.

Badania wykonano w laboratorium, celem określenia skuteczności proszku z części roślin Ricinodendron heudelotii, przeciwko szkodnikom przechowalnianym Sitophilus zeamais i Callosobruchus maculatus, odpowiednio na przechowywanym ziarnie kukurydzy i wspięgi pospolitej. Proszki z liści, kory pierwotnej i korzeni dodawano do 100 g ziarna w celu określenia toksyczności kontaktowej, uszkodzeń, wytwarzania potomstwa oraz kiełkowania ziarna. Uzyskane wyniki wskazywały na toksyczność materiałów roślinnych dla dwóch gatunków owadów i wywoływały śmiertelność S. zeamais i C. maculatus, wynoszącą odpowiednio 30 i 75%. Dający się zaobserwować poziom wywołanych szkód był istotnie (p ≤ 0,05) niższy w traktowanym ziarnie, natomiast wytwarzanie potomstwa przez obydwa gatunki owadów było istotnie (p ≤ 0,05) zredukowane. Kiełkowanie ziarna obydwu gatunków roślin nie zostało istotnie zmienione przez badane proszki. Przedyskutowano potencjalne wykorzystanie R. heudelotii w zwalczaniu szkodników przechowalnianych.