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2 Acta Biochimica Polonica

2 2001

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Ribozymes of the hepatitis delta virus: Recent findings on their structure, mechanism of catalysis and possible applications.

100%

Ciesiołka J. , Wrzesinski J. , Łęgiewicz M. , Smólska B. , Dutkiewicz M.

Acta Biochimica Polonica

2001

tom 48

nr 2

409-418

Although the delta ribozymes have been studied for more than ten years the most important information concerning their structure and mechanism of catalysis were only obtained very recently. The crystal structure of the genomic delta ribozyme turns out to be an excellent example of the extraordinary properties of RNA molecules to fold into uniquely compact structures. Details of the X-ray structure have greatly stimulated further studies on the folding of the ribozymes into functionally active molecules as well as on the mechanism of RNA catalysis. The ability of the delta ribozymes to carry out general acid-base catalysis by nucleotide side chains has been assumed in two proposed mechanisms of self-cleavage. Recently, considerable progress has been also made in characterizing the catalytic properties of trans-acting ribozyme variants that are potentially attractive tools in the strategy of directed RNA degradation.

Ribozymes of the hepatitis delta virus: Recent findings on their structure, mechanism of catalysis and possible applications

86%

Ciesiolka J. , Wrzesinski J. , Legiewicz M. , Smolska B. , Dutkiewicz M.

Acta Biochimica Polonica

2001

tom 48

nr 2

Although the delta ribozymes have been stud ied for more than ten years the most im- por tant in for ma tion con cern ing their struc ture and mech a nism of ca tal y sis were only ob tained very re cently. The crys tal struc ture of the genomic delta ribozyme turns out to be an ex cel lent ex am ple of the ex traor di nary prop er ties of RNA mol e cules to fold into uniquely com pact struc tures. De tails of the X-ray struc ture have greatly stim u- lated fur ther stud ies on the fold ing of the ribozymes into func tion ally ac tive mol e cules as well as on the mech a nism of RNA ca tal y sis. The abil ity of the delta ribozymes to carry out gen eral acid-base ca tal y sis by nu cle o tide side chains has been as sumed in two pro posed mech a nisms of self-cleavage. Re cently, con sid er able prog ress has been also made in char ac ter iz ing the cat a lytic prop er ties of trans-act ing ribozyme vari ants that are po ten tially at trac tive tools in the strat egy of di rected RNA degradation.