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Murine models of susceptibility to tuberculosis

100%

Beamer G. L. , Turner J.

Archivum Immunologiae et Therapiae Experimentalis

2005

tom 53

nr 6

469-483

Approximately one third of the world's population is infected with Mycobacterum tuberculosis, yet each year a small proportion of those individuals progress to an active disease state. Early identification and treatment of such individuals is essential to reduce transmission; however, genetic and immunological correlates of disease progression have not been well established in man. The murine model has been a central tool for the elucidation of protective immune mechanisms that are essential for controlling M. tuberculosis infection. Additionally, the study of inbred mice has revealed significant divergence in the susceptibility and disease progression of individual mouse strains to an infection with M. tuberculosis. The continued study of genetically disparate mouse strains has the potential to identify immune mechanisms that correlate with increasing susceptibility to tuberculosis. These mechanisms will be highly applicable to studies in man and assist in the early detection of individuals that are more vulnerable to the development of reactivation tuberculosis.

OPERATIONAL WINDMILL IN AN OPEN-AIR MUSEUM AS A CONSERVATION CHALLENGE: LESSONS FROM PROJECTS RECENTLY IMPLEMENTED IN POLAND

75%

Tomaszewski F. , Walczak B. M.

Muzeológia a kultúrne dedičstvo

2024

tom 12

nr 3

77 - 99

The article discusses the methods of protecting historic windmills and recognising them as valuable objects of industrial heritage. Therefore, examples of attempts to restore windmills as working mills after 2010 are discussed. Translocation combined with comprehensive renovation can be an effective and desirable method of conservation for historic windmills with a wooden structure, as it enables the restitution of these facilities as operating mills. However, one should be aware of the risks associated with this type of activity: primarily the risk of losing the historic, original substance of the mill and changing its landscape context. An important problem is the safety of the dynamic exhibition and the lack of professionals – millers specialised in the field of drive mills, which would be able to not only set up the technological process but also maintain the machines included in it on an ongoing basis. The following part of the article discusses 12 examples of attempts to restart historic windmills. These examples are divided into two categories of objects: windmills with an alternative, modern electric drive; windmills with the ability to work using only wind power. The analysed examples of windmill conservation and reactivation provide the basis for formulating lessons for future projects in Poland and abroad.