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2 Bromatologia i Chemia Toksykologiczna

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Ocena morfologiczna wloknotworczych wlasciwosci proszkowych srodkow gasniczych

100%

Witt M. , Mlynarczyk W. , Gustowska L. , Biczysko W.

tom 32

nr 4

375-382

Opisano spostrzeżenia nad zmianami morfologicznymi płuc szczurów po dotchawiczym wprowadzeniu proszków gaśniczych: Pollenitu F (LB-3) i Totalitu Super 80.

Pollenit F (LB-3) and Totalit Super 80 fire extinguisher agent powders were tested. Their possible harmful effects have not been evaluated yet. Both preparations contain silica and talc, hence they may be supposed to show fibrogenic properties. Male 3-month Wistar rats were used in the experiment. The animals received intratracheally single doses of 50 mg Pollenit F and 10 mg Totalit Super 80 in 0.5 cm3 aqueous 0.9% NaCl solution. The morphological changes in the lungs of the rats were evaluated after 1.5, 3 and 6 months. Activation of lung macrophages caused by the examined fire extinguisher powders results in progressive disseminated lung fibrosis. The observed formation of fibre complexes in which collagen fibres constitute the bulk of the occupied area seems to be a permanent change.

Biochemiczna ocena wloknotworczych wlasciwosci proszkowych srodkow gasniczych

88%

Mlynarczyk W. , Witt M.

Bromatologia i Chemia Toksykologiczna

1998

tom 31

nr 4

395-399

Przedstawiono wyniki eksperymentalnych badań biochemicznych włóknotwórczych właściwości proszkowych środków gaśniczych: Pollenitu F (LB-3) i Totalitu Super 80.

Powdered fire-extinguisher agents Pollenit F (LB-3) and Totalit Super 80 were tested. The agents have not been tested yet for their possible harmful effects. Both contain silica and talc, hence may be suspected of fibrogenic properties. Male Wistar rats were used in the tests. The animals received intratracheally 0.5 ml of aqueous 0.9% NaCl solution containing 50 mg Pollenit F and 10 mg Totalit Super 80. The following indices were evaluated after 1.5, 3 and 6 months: body weight, wet and dry lung weight, and total lung hydroxyproline content. In our experiment the test agents did not significantly affect body or lung weight, but caused a slight increase of hydroxyproline content. Our results point to a slight fibrogenic and negligible biological activity of Pollenit F and Totalit Super 80.