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  1. 10 Acta Parasitologica
  2. 5 Wiadomości Parazytologiczne
  3. 4 Acta Protozoologica
  4. 4 Cellular and Molecular Biology Letters
  5. 2 Acta Biochimica Polonica
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  1. 1 2022
  2. 2 2021
  3. 2 2019
  4. 1 2017
  5. 4 2016
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  1. 4 Myjak P.
  2. 3 Pietkiewicz H.
  3. 2 Bhasin V. K.
  4. 2 Bla B. K.
  5. 2 Djaman J. A.
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1
Content available The role of hematological parameters in differentiating Plasmodium falciparum and others – a study from Somalia
100%
Özdemir S. , Algın A. , Altunok İ. , Arslan E.
European Journal of Clinical and Experimental Medicine
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2022
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nr 4
430-434
EN
Introduction and aim. Accurate identification of Plasmodium species is important because of the differences in their treatment. We aimed to investigate the role of hematological and biochemical parameters in the differentiation of Plasmodium falciparum and other plasmodium species. Material and methods. This is a retrospective study. Patients admitted to the emergency department with signs and symptoms of malaria were included into the study. Patients with malaria were grouped as P. falciparum and others. Hematological parameters of two groups were compared by univariate and multivariate analysis. Statistical analysis was performed using the Jamovi. Results. A total of 107 patients were included in the study. According to univariant and multivariant analysis there was no difference in between two groups in the terms of blood urea nitrogen, aspartate aminotransferase, total bilirubin, hemoglobin, hematocrit, white blood cell count, platelet count, and mean platelet volume (in univariate analysis p values were 0.029, 0.011, 0.019, 0.171, 0.870, 0.307, 0.042, and 0.276, respectively and in multivariate analysis p values for blood urea nitrogen, aspartate aminotransferase, total bilirubin, hemoglobin, and platelet count were 0.100, 0.535, 0.328, and 0.213, respectively). Conclusion. The investigated hematological and biochemical parameters were found to be not valuable in predicting type of malaria. On the other hand, we recommend confirming the results of our study with larger samples and multicenter studies.
2
Content available remote Bacterially expressed truncated F2 domain of Plasmodium falciparum EBA-140 antigen can bind to human erythrocytes
88%
Rydzak J. , Kryńska K. , Suchanowska A. , Kaczmarek R. , Łukasiewicz J. , Czerwiński M. , Jaśkiewicz E.
Acta Biochimica Polonica
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2012
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tom 59
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nr 4
685-691
EN
The recently identified erythrocyte binding antigen-140 (EBA-140) is a member of the Plasmodium falciparum DBL family of erythrocyte binding proteins, which are considered as prospective candidates for malaria vaccine development. The EBA-140 ligand is a paralogue of the well-characterized P. falciparum EBA-175 antigen. They share homology of domain structure, including Region II, which consists of two homologous F1 and F2 domains and is responsible for ligand-erythrocyte interaction during invasion. It was shown that the F2 domain of EBA-175 antigen seems to be more important for erythrocyte binding. In order to study activity and immunogenicity of EBA-140 antigen F2 domain, it is necessary to obtain recombinant protein of high purity and in a sufficient amount, which used to pose a challenge due to the high content of disulphide bridges. Here, we present a new method for expression and purification of Plasmodium falciparum EBA-140 antigen F2 domain in E. coli Rosetta-gami strain in fusion with the maltose binding protein (MBP). The truncated F2 domain formed by spontaneous proteolytic degradation of the fusion protein was purified by affinity chromatography on Ni-NTA resin followed by size exclusion chromatography. Molecular mass of this protein was confirmed by mass spectrometry. Its N-terminal amino acid sequencing revealed a proteolytic cleavage site within the F2 domain. The proper folding of the recombinant, truncated F2 domain of EBA-140 antigen was confirmed by circular dichroism analysis. The truncated F2 domain can specifically bind to human erythrocytes but its binding is not as efficient as that of full Region II. This confirms that both the F1 and F2 domains of EBA-140 antigen are required for effective erythrocyte binding.
3
Content available G6PD Activity in Malaria Infected Children in Owerri
88%
Ihenetu F. C. , Nwachukwu M. I. , Ohalete C. N. , Njoku-Obi T. N. , Nwachukwu O. I. , Okoro C. I. , Okereke B. C. , Ihenetu S. C.
World News of Natural Sciences
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2017
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tom 12
63-72
EN
This paper is a study of G6PD activity in malaria-infected children in Owerri. Blood samples were collected from fifty-one (51) children hospitalized in the Federal Medical Center (FMC) and analyzed using standard Medical Laboratory methods. Results revealed that out of the 51 children examined (26 males and 25 females), 39, representing 76.47% of the total malaria infected children numbers, were G6PD deficient, while 12, representing 23.53%, had normal G6PD. Two different plasmodium species and their percentage occurrences were observed. These were: Plasmodium falciparum (78.43%) and Plasmodium malariae (21.57%). The work indicated that male children were more (P < 0.05) deficient than females, with percentage levels of 61.53% and 38.47%, respectively. In addition, children between the ages of 49-60 months was observed to be more (P < 0.05) G6PD deficient (with percentage of 25.64%), while those between 0-12 months were least G6PD deficient (with percentage of 8.3% (P < 0.05)). As being afflicted with malaria carries a high risk of Glucose-6-phosphate dehydrogenase (G6PD) deficiency in children, there is, therefore, urgent need for public enlightenment on public health implications, need for proper hygiene, as well as a need for strategies for preventing and controlling mosquito populations
4
Current approaches and problems in malaria vaccine development
75%
Gupta A. , Chaphalkar S. R.
European Journal of Biological Research
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2016
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tom 06
|
nr 1
5
Content available Design, molecular docking, drug-likeness, and molecular dynamics studies of 1,2,4-trioxane derivatives as novel Plasmodium falciparum falcipain-2 (FP-2) inhibitors
75%
Ghosh S. , Chetia D. , Gogoi N. , Rudrapal M.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2021
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tom 102
|
nr 3
6
In vitro antiprotozoal effects of nano-chitosan on Plasmodium falciparum, Giardia lamblia and Trichomonas vaginalis
75%
Elmi T. , Esboei B. R. , Sadeghi F. , Zamani Z. , Didehdar M. , Fakhar M. , Chabra A. , Hajialiani F. , Namazi M. J. , Tabatabaie F.
Acta Parasitologica
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2021
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tom 66
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nr 1
7
Ethanol extracts from Thai plants have anti-Plasmodium and anti-Toxoplasma activities in vitro
75%
Leesombun A. , Boonmasawai S. , Nishikawa Y.
Acta Parasitologica
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2019
|
tom 64
|
nr 2
8
Content available Cytoadhernecja w malarii mozgowej jako szczegolny przyklad parazytologii w ukladzie gospodarz-pasozyt
75%
Stelmach W. R. , Walski M. , Olszanski R.
|
|
nr 4
573-578
EN
Cerebral malaria in man and in animals is the consequence of a cascade of events, involving the patological changes, leading to the amplification of the expression of the receptors for cytoadherence on brain capillary endothelial cells. Sequestration is the process by which erytrocytes infected with the mature forms of the malaria parasite Plasmodium falciparum disappear from circulation and accumulate within venules and capillaries of various organs and tissues. The molecular mechanism in sequestration is one of the most rapidly advancing fields in malaria research. The several specific aspects considered in this paper. Our electron micrographs show cytoadherence in own model of cerebral malaria in rats infected with Plasmodium berghei.
9
Fourier transform infrared spectroscopy as a tool for identification of crude microbial extracts with anti-malarial potential
75%
Sankarganesh P. , Joseph B.
|
|
tom 61
|
nr 1
10
Chemosensitivity of a chloroquine-resistant Plasmodium falciparum isolate to quinine - type compounds in vitro
75%
Nair L. , Bhasin V. K.
Acta Protozoologica
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1993
|
tom 32
|
nr 2
11
In vitro gametocyte formation in Plasmodium falciparum isolates originating from a small endemic malarious area and their DNA profiling with an oligomer probe
75%
Mehra N. , Bhasin V. K.
Acta Protozoologica
|
1996
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tom 35
|
nr 2
12
Content available Trudnosci diagnostyczno-terapeutyczne malarii w Polsce
63%
Nahorski W. L. , Goljan J. , Wroczynska A. , Kuna A. , Myjak P. , Pietkiewicz H.
|
|
tom 53
168
13
Prevalence and distribution of human Plasmodium infection in Federally Administrative Tribal Areas of Pakistan
63%
Hussain I. , Qureshi N. A. , Afzal M. , Shaheen N. , Ali A. , Ashraf A.
|
|
nr 3
14
The in vitro antimalarial interaction of 9-hydroxycalabaxanthone and alpha-mangostin with mefloquine/artesunate
63%
Chaijaroenkul W. , Na-Bangchang K.
Acta Parasitologica
|
2015
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tom 60
|
nr 1
15
Content available Autoimmunologiczna trombocytopenia w nawracajacej polietiologicznej malarii [Plasmodium falciparum, Plasmodium vivax]
63%
Panasiuk A.
|
2001
|
tom 47
|
nr 1
85-89
EN
Thrombocytopenia frequently appear in severe malaria. The reasons of low blood platelets count are ditferent and its results of hypersplenism, subclinical course of intravascular coagulation (DIC). Thrombocytopenia from "consumption" is consequence of sequestration of blood platelets in blood vessels of lungs and cerebral. We examination 29 years old men, who was as forest worker in islands on Indonesia. He was treated with recurrent, poliethiological malaria (Plasmodium falciparum, Plasmodium vivax) and severe thrombocytopenia (17.0 GIL) without hepatosplenomegalia. Antiplatelet antibody was examined in blood serum by ELISA methods (GTI - PAKPLUS®). In blood serum was detected IgG antibody against glicoprotein receptors on surface of blood platelets GPIIb/IIIa, GPIV, GPIb/IX, GPV, GPIa/IIa. Chronic infections of Plasmodium may conduct to autoimmune destruction of blood platelets.
16
Content available A novel approach for identifying DNA repair pathways proteins using an evolutionary approach: Plasmodium falciparum case study
63%
Milanowska K. , Wojtczak J.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2016
|
tom 97
|
nr 4
17
Polymorphism of PFCRT and PFMDR-1 genes of Plasmodium falciparum and chloroquine susceptibility in Cote d'Ivoire
63%
Djaman J. A. , Bla B. K. , Yavo W. , Yapi H. F. , Mazabraud A. , Basco L. K.
Acta Protozoologica
|
2007
|
tom 46
|
nr 4
361-365
18
A search for antiplasmodial metabolites among fungal endophytes of terrestrial and marine plants of Southern India
63%
Kaushik N. K. , Murali T. S. , Sahal D. , Suryanarayanan T. S.
Acta Parasitologica
|
2014
|
tom 59
|
nr 4
EN
Eighty four different fungal endophytes isolated from sea grasses (5), marine algae (36) and leaves or barks of forest trees (43) were grown in vitro and the secondary metabolites secreted by them were harvested by immobilizing them on XAD beads. These metabolites were eluted with methanol and screened using SYBR Green I assay for their antiplasmodial activity against blood stage Plasmodium falciparum in human red blood cell culture. Our results revealed that fungal endophytes belonging to diverse genera elaborate antiplasmodial metabolites. A Fusarium sp. (580, IC50: 1.94 μg ml−1) endophytic in a marine alga and a Nigrospora sp. (151, IC50: 2.88 μg ml−1) endophytic in a tree species were subjected to antiplasmodial activity-guided reversed phase high performance liquid chromatography separation. Purification led to potentiation as reflected in IC50 values of 0.12 μg ml-1 and 0.15 μg ml−1 for two of the fractions obtained from 580. Our study adds further credence to the notion that fungal endophytes are a potential storehouse for a variety of novel secondary metabolites vested with different bioactivities including some that can stall the growth of the malaria parasite.
19
Content available Zimnica - Plasmodium falciparum - trudny problem diagnostyczny i terapeutyczny
63%
Kociecka W. , Skoryna B. , Kurczewska M. , Myjak P.
Wiadomości Parazytologiczne
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1988
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tom 34
|
nr 4-6
EN
The authors deal with the problem of malaria induced by Plasmodium falciparum and imported to Poland by people returning from tropics. They stress significance of the variable clinical pattern involved and of chloroquine resistance. Basing on their own observations of a definitely diagnosed malaria (22 out 35 cases observed and suspected of malaria) the authors discuss diagnostic and therapeutic difficulties encountered in 7 patients with Plasmodium falciparum-induced malaria. Two representative cases of malaria (Plasmodium falciparum) have been discussed in detail. One of the cases with malaria imported from tropics, presented severe course and an atypical clinical pattern (with involvement of central nervous system) which made appropriate diagnosis difficult and delayed application of specific causal treatment. The other unusual case involved a nurse who contracted Plasmodium through a small skin wound with which patient's blood came into contact when the nurse was drawing blood for testing. Course of the disease was grave, with deep anaemia and central nervous system and kidney involvement. In both cases the disease had favourable outcome due to complex anti-malarial therapy and multispecific medical intervention.
20
Oczyścić morowe powietrze
63%
Jagielski T.
Wiedza i Życie
|
2008
|
nr 02
46-50
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