Wyniki wyszukiwania - Biblioteka Nauki

1

Data mining and neural network simulations can help to improve deep brain stimulation effects in parkinson’s disease

100%

Szymański A. , Kubis A. , Przybyszewski A. W.

Computer Science

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2015

|

tom Vol. 16 (2)

199--215

EN

Parkinson’s Disease (PD) is primary related to substantia nigra degeneration and, thus, dopamine insufficiency. L-DOPA as a precursor of dopamine is the standard medication in PD. However, disease progression causes L-DOPA therapy efficiency decay (on-off symptom fluctuation), and neurologists often decide to classify patients for DBS (Deep Brain Stimulation) surgery. DBS treatment is based on stimulating the specific subthalamic structure: subthalamic nucleus (STN) in our case. As STN consists of parts with different physiological functions, finding the appropriate placement of the DBS electrode contacts is challenging. In order to predict the neurological effects related to different electrodecontact stimulations, we have tracked connections between the stimulated part of STN and the cortex with the help of diffusion tensor imaging (DTI). By changing a contacts number and amplitude of stimulus (proportional in size to stimulated area), we have determined connections to cortical areas and related neurological effects. We have applied data mining methods to predict which contact (and at what amplitude) should be stimulated in order to improve a particular symptom. We have compared different data mining methods: Wekas Random Forest classifier and Rough Set Exploration System (RSES). We have demonstrated that the Weka classifier was more accurate when predicting the effects of stimulations on general neurological improvements, while RSES was more accurate when using specific neurological symptoms. We have simulated other effects of stimulation related to the interruption of pathological oscillation in the basal ganglia found in PD. Our model represents possible STN neural population with inhibitory and excitatory connections that have pathologically synchronized oscillations. High-frequency electrical stimulation has interrupted synchronization. something that is also observed in PD patients.

2

INFLUENCE OF PHYSICAL REHABILITATION ON SOCIAL NETWORKS AND QUALITY OF LIFE AMONG PEOPLE WITH PARKINSON’S DISEASE

100%

Lizoń K. , Cholewa J. , Uher I.

Journal of Physical Education & Health - Social Perspective

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2017

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tom 6

|

nr 10

35-42

XX

Parkinson's Disease (PD) is the second most common neurodegenerative disease. Symptoms relate to the movement and cognitive sphere; they have a negative impact on the quality of life of people suffering from PD. Pharmacotherapy and rehabilitation slow the progression of the disease. The aim of the work was to determine the impact of physical rehabilitation on the level of social relations in the context of the quality of life of people with PD. 47 people with idiopathic PD were involved in the study, all were in the second stage of the disease according to the Hoehn & Yahr scale. The Courage Social Network Index (CSNI) was used to assess social relations. The scales: Quality of Life in Parkinson’s Disease 39 (PDQ-39), Medical Outcomes Study 36-item Short-Form Heath Survey (SF-36) and Parkinson’s Disease Quality of Life Questionnaire (PDQL) were applied in order to evaluate the quality of life of patients The subjects were divided into two groups: research and control. The research group took part in a rehabilitation program two times a week for 45 minutes for three months. The control group did not participate in any form of physical rehabilitation. The results of the research showed a significantly higher level of social bonds as well as quality of life of people with PD participating in physical rehabilitation. At the same time, a higher level of correlation between the level of social bonds and the level of quality of life was found in the research group. Therefore, the positive impact of physical rehabilitation on the level of social bonds and the quality of life of people with PD constituted the conclusion of the work.

3

Early effect of thalamotomy on cognitive function in patients with Parkinson’s disease

100%

Gorzelańczyk E. J. , Ackermann-Szulgit D. , Kunc M. , Harat M. , Walecki P.

Bio-Algorithms and Med-Systems

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2018

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tom Vol. 14, no. 1

art. no. 20180005

EN

Thalamotomy is a neurosurgical procedure used in the treatment of advanced Parkinson’s disease (PD). The aim of our research is to evaluate the early impact of a lesion in the ventrointermedial nucleus (VIM) of the thalamus on cognitive and motor function in people with PD. Sixty patients who qualified for right- or leftsided VIM thalamotomy were involved in the study. The cognitive and motor functions of each patient were assessed both prior to and following the surgical procedure. Twenty-nine PD patients without ablative treatment were qualified for the comparison group, and 57 neurologically healthy individuals were assigned to the control group. The following tests were carried out: Mini Mental State Examination, Benton Visual Retention Test, Stroop Color and Word Test, Trail Making Test A&B, and Rey Auditory Verbal Learning Test. Statistically significant differences were found in reaction time, visual-spatial working memory, auditory-verbal memory, and overall level of cognitive function when comparing the results of tests carried out before and after thalamotomy and when comparing patients who had undergone surgery with untreated or healthy individuals. In patients with right-sided and left-sided thalamotomy differences were also found in the mean number of perseverative errors and recalled words.

4

Altered oxidative stress levels in Indian Parkinson's disease patients with PARK2 mutations

100%

Vinish M. , Anand A. , Prabhakar S.

Acta Biochimica Polonica

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2011

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tom 58

|

nr 2

165-169

EN

The aim of this pilot study was to determine the baseline state of oxidative stress indices in patients with Parkinson's disease (PD). Peripheral blood samples of 15 PD subjects were analyzed and compared with ten age matched healthy controls. Patients with PARK2 mutations were also compared with PD patients without mutations. There was significant increase in malondialdehyde content and superoxide-dismutase (SOD) activity in peripheral blood parameters in PD patients (p < 0.05) in comparison to controls. These findings suggest an important role of oxidative stress in Parkinson's disease evolution and progress. No changes were observed in glutathione peroxidase and nitric oxide levels. We found significant correlation between SOD activity and lipid peroxidation when the biochemical data was further analyzed. In addition, significant increase in the levels of SOD among the PD patients with PARK2 mutations was observed, which can be ascribed to chronic oxidative stress induced by PARK2 mutations.

5

Antioxidant properties of PF9601N, a novel MAO-B inhibitor: assessment of its ability to interact with reactive nitrogen species

88%

Bellik L. , Dragoni S. , Pessina F. , Sanz E. , Unzeta M. , Valoti M.

Acta Biochimica Polonica

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2010

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tom 57

|

nr 2

235-239

EN

The novel MAO-B inhibitor PF9601N, its cytochrome P450-dependent metabolite FA72 and l-deprenyl were studied as potential peroxynitrite (ONOO-) scavengers and nitric oxide synthase (NOS) inhibitors. The scavenging activity of these compounds was evaluated by measuring the oxygen consumption through peroxynitrite-mediated oxidation of both linoleic acid and brain homogenate. FA72, PF9601N and l-deprenyl caused a concentration-dependent inhibition of ONOO--induced linoleic acid oxidation with an IC50 value of 60.2 µM, 82.8 µM and 235.8 µM, respectively. FA72 was the most potent also in inhibiting ONOO--induced brain homogenate oxidation with an IC50 value of 99.4 µM, while PF9601N and l-deprenyl resulted weaker inhibitors in the same experimental model, showing an IC50 value of 164.8 and 112.0 µM, respectively. Furthermore, both the novel MAO-B inhibitor as well as its metabolite were able to strongly inhibit rat brain neuronal NOS (IC50 of 183 µM and 192 µM, respectively), while l-deprenyl at the highest concentration used (3 mM), caused only a slight decrease of the enzyme activity. Moreover, inducible NOS was strongly inhibited by FA72 only. All these results suggest that PF9601N could be a promising therapeutic agent in neurodegenerative disorders such as Parkinson's disease.

6

Physiological upper limb's tremor research using computer tablet

88%

Lech T.

Prace Naukowe Instytutu Matematyki i Informatyki Politechniki Częstochowskiej

|

2004

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tom Vol. 3, nr 1

81--89

EN

The paper presents the research results of the computer tablet application in the diagnostics of physiological tremor of hands. The said research is a continuation of a wider research process aiming at the creation of a compact diagnostic system of nervous system diseases appearing in, inter alia, hand's tremor. The application of properly programmed computer tablet makes it possible to carry out the examination of the upper limb's tremor in a fast, easy and cheap way, assisting the neurologists in the diagnostic process, therefore the use of a very expensive medical equipment (EMG, accelerometer) can be minimized. Needless to say, the compact diagnostic system of hands' tremor and co-related tremors of the nervous system pathology must correctly diagnose the physiological tremor. In order to do it a comparative examination has been performed in healthy patients whose physiologic tremor has been intensified by adequate methods. The application of the Fourier transform and time/frequency relation enabled the analysis of signals and performance of the comparative analysis involving the data gathered in patients with clinically confirmed Parkinson's disease.

7

The differentiation of slow and fast types of acetylation in Parkinson's disease - a study using molecular markers

88%

Klodowska-Duda G. , Opala G. , Samelska J. , Ochudlo S. , Mazurek U. , Wilczok T.

Cellular and Molecular Biology Letters

|

2002

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tom 07

|

nr Suppl.

8

Postural stability in Parkinson’s disease patients

75%

Wilczyński J. , Pedrycz A. , Zieliński E. , Ambroży T. , Mucha D.

Acta of Bioengineering and Biomechanics

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2017

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tom Vol. 19, no. 4

135--141

EN

Purpose: The aim of the study was to analyze postural stability in Parkinson's disease patients. A total of 32 subjects were tested, including 26 (81.25%) women and 6 (18.75%) men. These were patients with advanced, idiopathic Parkinson’s disease. The disease duration was over 5 years. Methods: The study was conducted in the Posturology Laboratory at the Department of Medicine and Health Sciences, Jan Kochanowski University in Kielce (Poland). The Biodex Balance System was used for evaluation of postural stability. Postural Stability Testing was performed with both feet positioned on a stable surface with the eyes open. Results: The Overall Stability Index in the whole group was 0.5°. The higher Overall Stability Index in women is indicative of slightly worse postural stability compared to men, although in both groups, it was within norms (Z = 2.0545, p = 0.0399). Anterior-Posterior Overall Stability Index (A/P) was an average of 0.35°. The Medial-Lateral Overall Stability Index (M/L) was an average of 0.27°. Both women and men were observed to have higher postural sway in the sagittal plane than the frontal plane. The vast majority of the subjects maintained in Zone A during testing (99.94%), and was slightly bent backwards to the right and in Quadrant IV (61.53%). Conclusions: Regular control of postural stability in Parkinson's disease patients is significant due to the risk of falls.

9

Zintegrowany system pozyskiwania i analizy obrazu spirali Archimedesa w ocenie stropnia dysfunkcji pacjentów dotkniętych schorzeniem Parkinsona

75%

Maj P. , Kowalski P. , Tekieli W.

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska

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2011

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tom nr 2

21-24

PL

Przedmiotem pracy jest kliniczny system oceny stopnia dysfunkcji manualnej osób cierpiących na schorzenia drżenia rąk. Podlegająca późniejszej ocenie informacja o drżeniu rąk pobierana jest poprzez panel dotykowy tablet-PC, w sposób symulujący klasyczną metodę spirali Archimedesa. Ruch ręki sparametryzowano przez 15 arbitralnie dobranych innowacyjnych współczynników amplitudowych, czasowych oraz częstotliwościowych. Ich analizę przeprowadza sztuczna sieć neuronowa, wystawiająca badanym oceny w skali 0-10. Trafny dobór parametrów potwierdzany jest przez średni stopień ich korelacji z ocenami. Dalsza optymalizacja modułu analitycznego może w konsekwencji umożliwić stosowanie prototypowanego rozwiązania w praktyce klinicznej.

EN

The main aim of current article is to introduce prototyped system of hand tremor analysis for people suffering from Parkinson's disease. It was designed after authors found out, that there is significant need for system that would allow assessing peoples hand tremor level in some normalized manner [1, 4]. Whole application, developed using LabVIEW 2009 graphical environment [11], was divided into two independent modules - acquisition and analysis. The signal acquisition is bases on classic Archimedean Spiral method, involving tablet-PC touch screen and specialized pen instead of paper and pencil. Patients hand movement is recorded during the whole process of drawing spiral, and then described using 15 innovative amplitude, acceleration and frequency parameters. Those coefficients stand as input values for the second module - analysis. In this case a three layer cascade artificial neural network with backpropagation was utilized for best performance and flexibility [4, 8]. Network was implemented using MATLAB R2008a environment and taught by marks given to patients by neurologists. Studies carried out on group of patients with Parkinson's disease shown, that chosen parameters have correlation level of 0.58, with marks given by specialists. Moreover, database structure allows provided software to be connected with Hospital Information System [2], so the developed application is well suitable for being widely used in clinical practice.

10

Gut microbiota in neurological disorders

75%

Grochawska M. , Laskus T. , Radkowski M.

Archivum Immunologiae et Therapiae Experimentalis

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2019

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tom 67

|

nr 6

11

Aparat rejestrujący drżenie w chorobie Parkinsona z zastosowaniem akcelerometru MEMS

75%

Karaś K. , Tutaj J.

Aktualne Problemy Biomechaniki

|

2013

|

tom z. 7

87--92

PL

Głównym celem artykułu jest opis prototypu aparatu do rejestracji drżenia, którego najważniejszym elementem jest akcelerometr. W artykule zawarto kryteria wyboru czujnika do pomiaru tremoru oraz wyjaśniono zasadę działania termicznego akcelerometru MEMS, który jest zasadniczym elementem skonstruowanego przyrządu. W celu zaprezentowania działania urządzenia zamieszczono przebiegi czasowe sygnału pomiarowego pochodzące od dwóch pacjentów ze zdiagnozowaną chorobą Parkinsona.

EN

The main aim of this article is to describe a prototype device for measuring tremor in Parkinson Disease. Device is based on thermal accelerometer constructed in MEMS technology The article includes criteria for selecting a sensor for measuring tremor and explains the principle of operation of thermal MEMS accelerometer. Article included measuring signal waveforms derived from two patients diagnosed with Parkinson's disease.

12

Parametric analysis of pilot voice signals in Parkinson’s disease diagnostics

75%

Majda-Zdancewicz E. , Potulska-Chromik A. , Nojszewska M. , Kostera-Pruszczyk A.

Journal of Automation, Electronics and Electrical Engineering

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2022

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tom Vol. 4, No. 1

21--28

EN

Parkinson's disease (PD) is a neurodegenerative disease of the central nervous system (CNS) characterized by the progressive loss of dopaminergic neurons in the substantia nigra. The article describes an analysis of pilot voice signal analysis in Parkinson's disease diagnostics. Frequency domain signal analysis was mainly used to assess the state of a patient's voice apparatus in order to support PD diagnostics. The recordings covered uttering the “a” sound at least twice with extended phonation. The research utilized real recordings acquired in the Department of Neurology at the Medical University of Warsaw, Poland. Spectral speech signal coefficients may be determined based on different defined frequency scales. The authors used four frequency scales: linear, Mel, Bark and ERB . Spectral descriptors have been defined for each scales which are widely used in machine and deep learning applications, and perceptual analysis. The usefulness of extracted features was assessed taking into account various methods. The discriminatory ability of individual coefficients was evaluated using the Fisher coefficient and LDA technique.. The results of numerical experiments have shown different efficiencies of the proposed descriptors using different frequencies scales.

PL

Choroba Parkinsona (PD) jest neurodegeneracyjną chorobą ośrodkowego układu nerwowego charakteryzującą się postępującą utratą neuronów dopaminergicznych w istocie czarnej. W artykule opisano analizę rejestracji pilotażowych sygnałów głosu w diagnostyce choroby Parkinsona. Rejestracji podlegało co najmniej dwukrotnie wypowiadanie głoski "a” o przedłużonej fonacji. Do badań wykorzystano nagrania zarejestrowane w Katedrze i Klinice Neurologii Warszawskiego Uniwersytetu Medycznego w Warszawie. Do oceny stanu aparatu głosu pacjenta celem wsparcia diagnostyki choroby Parkinsona wykorzystano w głównej mierze analizę sygnału w dziedzinie częstotliwości. Autorzy zastosowali cztery skale częstości: liniową, skalę typu Mel, skalę typu Bark oraz skalę typu ERB. Dla każdej z tych skali zdefiniowali deskryptory spektralne szeroko stosowane w aplikacjach uczenia maszynowego i głębokiego uczenia się oraz w analizie percepcyjnej. Ocena przydatności wyekstrahowanych cech została zrealizowana z uwzględnieniem różnych metod. Wykorzystano metodą oceny jakości cech przy użyciu współczynnika istotności Fischera oraz analizę LDA. Wyniki eksperymentów numerycznych wykazały różne wydajności proponowanych deskryptorów przy użyciu różnych skal częstości.

13

An influence of lesions of the catecholaminergic cerebellar innervation on the harmaline-induced tremor in rats

75%

Wardas J. , Kolasiewicz W. , Kuter K. , Berghauzen K. , Nowak P. , Mikolajun U. , Zapala M. , Ossowska K.

Acta Neurobiologiae Experimentalis

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2013

|

tom 73

|

nr 1

EN

Recent studies have suggested a crucial role of the cerebellum in different forms of tremor. Abnormal synchronous activation of the glutamatergic olivo-cerebellar pathway and Purkinje cells results in the essential tremor in humans and the harmaline-induced tremor in animals. Moreover, an increased neuronal activity of the cerebellum has been found to contribute to the tremor in Parkinson’s disease (PD). Since the cerebellum receives dopaminergic and noradrenergic pathways arising from regions affected in PD, the aim of the present study was to examine a contribution of the cerebellar catecholaminergic innervation to the harmaline-induced tremor in rats. Rats were bilaterally injected into the cerebellar vermis (lobules 8–10) with 6-hydroxydopamine (6-OHDA) (8 μg/0.5 μl) either alone or this treatment was preceded by desipramine (15 mg/kg i.p.). Harmaline was administered at a dose of 7.5 mg/kg i.p. on the 9th post-operative day. Tremor of forelimbs was measured as a number of episodes. After completion of behavioural experiments rats were killed by decapitation and the levels of monoamines and their metabolites were measured by HPLC in lobules 1–3, 4–7 and 8–10 of the cerebellum. 6-OHDA injected alone decreased the noradrenaline level by ca. 40–80% in the cerebellum and enhanced the harmaline-induced tremor. When 6-OHDA administration was preceded by desipramine, it decreased dopaminergic transmission in some regions of the cerebellum but induced its compensatory activation in others. Finally no influence of the latter treatment on the tremor induced by harmaline was observed. The present study indicates that the noradrenergic innervation of the cerebellum plays an inhibitory role in the harmaline-induced tremor. The study was supported by the grant of the Ministry of Science and Higher Education No N N401 570638, and partly by Statutory Funds of the Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland.

14

Evaluation of chosen gait parameters in patients with the Parkinson's disease

75%

Sobolak M. , Minta P.

Physiotherapy

|

2009

|

tom 17

|

nr 1

45-52

PL

Celem pracy była ocena niektórych parametrów chodu osób z chorobą Parkinsona przy przechodzeniu odcinków prostych określonej trasy i slalomu. Badaniem objęto dwie grupy: grupę badawczą złożongą z 17 chorych na chorobę Parkinsona (średnia wieku 71 lat) i 17-osobową grupę kontrolną reprezentowaną przez osoby zdrowe (średnia wieku 70 lat). Badanie polegało na przejściu trasy, uwzględniającej odcinki proste i slalomu, wytyczonej wg pomysłu autorów pracy. Osoby z chorobą Parkinsona osiągały gorsze parametry chodu w stosunku do osób zdrowych w analogicznym przedziale wiekowym, zwłaszcza na odcinkach slalomu.

EN

The aim of the paper was to evaluate chosen gait parameters in patients with the Parkinson's disease while walking on straight sections and slalom of a chosen route. The research covered two groups: the examination group numbering 17 patients with the Parkinson's disease (average age 71 years) and the control group including 17 healthy people (average age 70 years). The examination was based on covering a route consisting of straight sections and slaloms, designed according to the idea of the authors. Patients with the Parkinson's disease achieved worse results in comparison with healthy people of similar age, especially on the slalom distances.

15

Wykorzystanie nadgarstkowego rejestratora drżeń kończyn do monitorowania pacjentów z chorobami układu pozapiramidowego

75%

Kornacki W. , Pikiel M. , Dobrowiecka B. , Pakszys W.

Prace Przemysłowego Instytutu Elektroniki

|

2001

|

tom nr 146

145-151

16

Diagnosing Parkinson’s disease using the classification of speech signals

75%

Froelich W. , Wróbel K. , Porwik P.

Journal of Medical Informatics & Technologies

|

2014

|

tom Vol. 23

187--193

EN

This paper addressees the problem of an early diagnosis of Parkinson’s disease by the classification of characteristic features of person’s voice. A new, two-step classification approach is proposed. In the first step, the voice samples are classified using standard state-of-the-art classifiers. In the second step, the classified samples are assigned to patients and the final classification process based on majority criterion is performed. The advantage of using our new approach is the resulting, reliable patientoriented medical diagnose. The proposed two-step method of classification allows also to deal with the variable number of voice samples gathered for every patient. Preliminary experiments revealed quite satisfactory classification accuracy obtained during the performed leave-one-out cross validation.

17

Ropinirol : generyczny lek przeciw chorobie Parkinsona

75%

Chmielowiec U.

Przemysł Chemiczny

|

2006

|

tom T. 85, nr 5

347-348

PL

W Instytucie Farmaceutycznym opracowano wieloetapową syntezę otrzymywania chlorowodorku 4-[2-(dipropyloamino)-etylo]1,3-dihydro2H-indol-2-onu (chlorowodorek ropinirolu). Z dziesięciu etapów syntezy redukcja wyjściowego kwasu 2-metylo-3-nitrobenzoesowego do odpowiedniego alkoholu, reakcja przedłużenia łańcucha i redukcji z jednoczesną cyklizacją odgrywają decydującą rolę w procesie wytwarzania końcowego produktu.

EN

A 10-step synthesis was developed to prep. 99.8% pure 4[2-(dipropylamino)-ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride. Redn. of the starting 2-methyl-3-nitrobenzoic acid to a corresponding alcohol, the reaction of chain extension, and reductive cyclization to the indolone ring are the crucial steps.

18

Subthalamic nucleus deep brain stimulation in Parkinson's disease

75%

Mandat T. , Koziara H. , Nauman P. , Tykocki T. , Bonicki W.

Biocybernetics and Biomedical Engineering

|

2011

|

tom Vol. 31, no. 3

47-55

EN

A group of 37 patients diagnosed with Parkinson's disease (PD) were treated with subthalamic deep brain stimulation (STN DBS). The mean age at implantation was 59 - 11 years and PD has been present from 6 to 17 years (mean 9). The STN was identified by direct and indirect methods: macro stimulation and microrecording in all cases. At a three month follow-up, the authors observed a mean reduction of 49% in UPDRS II score and a mean reduction of 65% in UPDRS III score. Mean reduction of 1-dopa consumption was 62%. The authors concluded that STN DBS safely reduces disabling symptoms of PD.

19

Wykorzystanie akcelerometru do pomiaru drżenia kończyn górnych

75%

Radomski D.

Prace Naukowe Politechniki Warszawskiej. Elektronika

|

2007

|

tom z. 161

107-112

EN

Tremor measuring and analysis is a classical diagnostic procedure used in patients with Parkinson`s disease. This paper presents the extension of a tremor analysi enabled through the application of two-axes accelometer with a measuring sensitivity up to 2g.. This measuring sensitivity allowed to measure resting micro-tremors of upper limbs whose sources are finger`s arteriolies. The power spectrum of the analyzed tremor was estimated by continoous wavelet transform using Morlet wavelet as a mother wavelet. The proposed method indicated that the administrated drug caused and identified change of low frecuencies in patients with hypertension. Moreover, it was observed that low frequency oscillations in a rest tremor of upper limbs may coexist with subclinical hypertension.

20

System pomiarowy do rejestracji drżeń parkinsonowskich

75%

Piwowar P. , Ćwik T. , Cianciara C.

Przegląd Elektrotechniczny

|

2014

|

tom R. 90, nr 5

130--133

PL

W pracy zaprezentowano system pomiarowy umożliwiający dokładny i powtarzalny pomiar drżeń parkinsonowskich kończyn górnych. Prawidłowe rozpoznanie choroby Parkinsona jest kluczowe dla wyboru właściwego sposobu leczenia pacjenta. Niestety większość klinicznych kryteriów diagnostycznych wymaga szczegółowej historii choroby oraz długiego czasu obserwacji pacjenta. Dostępne obecnie specjalistyczne metody badań, są dość drogie i nie nadające się do powszechnego zastosowania. Zaproponowane rozwiązanie, oparte na trójosiowym czujniku przyśpieszenia może zapewnić stosunkowo szybką i dokładną diagnozę.

EN

In this paper, the authors present the hand tremor measurement system. The correct diagnosis of Parkinson's disease is crucial for the selection of proper treatment and future prognosis. Unfortunately most of clinical diagnostic criteria require a detailed patient history and long observation time. There are also available specialist survey methods, but they are quite expensive and not suitable for general diagnosis. The proposed solution is to use acceleration sensor can provide possibly fast and accurate diagnosis.