Wyniki wyszukiwania - Biblioteka Nauki

1

Effects of maternal thiamine deficiencies on the pyramidal and granule cells of the hippocampus of rat pups

100%

Ba A. , N'Douba V. , D'Almeida M.-A. , Seri B. V.

Acta Neurobiologiae Experimentalis

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2005

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tom 65

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nr 3

378-398

EN

To understand the implication of thiamine deficiency in the neuronal atrophy and cell death we undertook to induce thiamine (B1 vitamine) deficiency during three essential periods of the ontogenesis of rat central nervous system (CNS). Female rats were fed with a thiamine deprived diet during the gestation and lactation, and the fetuses and pups were alternately exposed to prenatal, perinatal or postnatal thiamine deficiencies. On the 45th postnatal day, histological studies were done on the brains of the pups and the structure of the hippocampus was analyzed. The effects of each treatment were assessed by measuring the size and the density of cell nuclei throughout the dentate gyrus and fields CA4, CA3 and CA1 of the hippocampal formation. The hippocampus showed a regional vulnerability in the pups exposed to maternal thiamine deficiencies. It appears that the thiamine deficiency decreased nuclear density (27.20%) more severely than nuclear size (10.56%) in the fetal hippocampus. Consequently, the major part of the teratogenic effects of thiamine deficiency was cellular death, rather than cellular atrophy.

2

Anisakis simplex (Rud., 1809) (Nematoda: Anisakidae): growth and morphometry of larvae from spring spawning herring (Clupea harengus membras L.) in the Vistula lagoon and adjacent areas of the Baltic Sea

100%

Shukhgalter O.

Oceanological Studies

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2002

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tom 31

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nr 1-2

67-73

EN

Third-stage A. simplex larvae are described infesting baltic herring in the Vistula Lagoon and adjacent areas of the Baltic Sea (ICES-subdivisions 26). Morphometric measurements and peculiarities of allometric growth of A. simplex larvae are similar to those found as larvae of fishes in other regions, range size was wider. Growth of A. simplex larvae during spawning migration of their hosts was noted. High infestation (up to 375 specimens per fish) and the wide size range of larvae (8.0-30.0 mm) confirms that the third-stage A. simplex larvae stay alive in their hosts and increase over time.

3

Villous trophoblast cell turnover in placentas from preterm pregnancy and pregnancy complicated by intrauterine growth restriction (IUGR)

100%

Zadrozna M. , Nowak B. , Marcinek A. , Duc J.

Folia Biologica

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2010

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tom 58

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nr 1-2

79-83

EN

Disturbed trophoblast turnover, a key process in placental physiology, may lead to a number of pregnancy-associated pathologies. This study examines PCNA expression and describes and quantifies morphological changes during trophoblast turnover in preterm placentas and termplacentas complicated by IUGR. The number of CTF cells increased two-fold in preterm and IUGR placentas. A concurrent and slightly reduced proliferation rate of these cells was also found. The number of STF nuclei of terminal villi was lower by 21%in IUGR and by 18% in pretermplacentas (P>0.05). A statistically significant reduction of the number of syncytial knots by 50% as compared to the control placentas was observed. Correlations between PCNA-reactive CTF nuclei and syncytial knots, PCNA-reactive CTF nuclei and CCO activity, and CCO activity and syncytial knots were found. Moreover, a strong inverse relation was observed between syncytial knots and CTF cells, and CCO activity and CTF cells.

4

Mast cells in the mouse mammary gland ? correlation with the development of lactiferous structures

88%

Szewczyk G. , Szukiewicz D. , Zaczek R. , MaslinskA D.

Folia Biologica

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2000

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tom 48

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nr 1-2

13-17

EN

Specimens of mouse mammary glands obtained from animals being in different phases of reproductive cycle were collected. After staining MCN, the total mast cell area (TMC), mean mast cell area (MMC), and lactiferous structure density index (LDI) were examined in sections, using a computer image analysis system. Statistically significant (P<0.05) results were: 1. An increase in MCN observed in Group I (4-5 and 9-10 days of pregnancy), a decrease in MCN observed in Group II (2nd and 10th day of lactation); 2. Changes of TMC fully corresponding to changes of MCN; 3. Increase in MMC observed in Group I at mid (days 9-10) and at the end (days 18-19) of pregnancy, decrease in MMC observed in Group IIB (10th day of lactation); 4. LDI (%) higher at the end of pregnancy (Group IC) and during lactation (groups IIA, IIB), compared with control (23.5 ? 4.12, 37.6 ? 3.24, 71.0 ? 4.33 vs. 3.8 ? 0.39). The observed changes in the number and size of MC strictly correspond to physiological phenomena leading to alternation of the mouse mammary gland functional status by development/involution of the lactiferous structures.

5

Different developmental rates of selected brain structures in humans

88%

Dambska M. , Kuchna I.

Acta Neurobiologiae Experimentalis

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1996

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tom 56

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nr 1

83-93

EN

Various rates of development are characteristic for particular structures of the human central nervous system (CNS). The differences of the maturing brain steam and telencephalon are evident in routine neuropathological examination. The fetal and postnatal archi- and neocortex also reveals uneven levels of maturation. In order to precisely describe those differences in humans we performed a morphological and morphometric study on the dorsal vagal nucleus of the medulla oblongata, on Ammon's horn and on neocortex from midgestation to the 18th postnatal month. The numerical density of neurones, cell perikarya andnuclear cross-sectional area, and the ratio of nucleus to perikaryon area were measured. The results demonstrate a development-dependent decrease in cell density and progressive differentiation of neurones according to their changing size. They express a process of maturation which differs in rate across the CNS structures examined.

6

The second layer neurones of the entorhinal cortex and the perforant path in physiological agening and Alzheimer's disease

75%

Morys J. , Sadowski M. , Barcikowska M. , Maciejewska B. , Narkiewicz O.

Acta Neurobiologiae Experimentalis

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1994

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tom 54

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nr 1

47-53

7

Recent environmental toxic effect in the Polish Copper Mining Territory on human reproduction. Part I. Response of the placenta to the chemical stress

75%

Zadrozna M.

Folia Biologica

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2003

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tom 51

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nr 3-4

201-205

EN

collected from healthy non-smoking women living in the high polluted region, i.e. the Copper Mining Territory (CMT) and the 38 control placentas (C) obtained from little polluted eastern Carpathian regions. The placentas were studied by histochemical, immunohistochemical and morphometric methods. In CMT placentas a decrease in the cytochrome c oxidase and glucose-6-phosphate activities and the immunoreactivity of glutathione S-transferase pi in the villous syncytiotrophoblast and amniotic epithelium was noted. All CMT placentas showed abundance of mineral and fibrinoid deposits and of lipid droplets. This produced a compensatory increase in the mother-fetus exchange area due to excessive proliferation of placental villi which in turn decreased the intervillous space and thus the influx of indispensable maternal blood. Lately slight signs of increase in the cytochrome c oxidase activity accompanied by a noticeable decrease in number of the thinnest (most abundant) terminal villi is observed.