Wavelet based seizure detection is an importance topic for epilepsy diagnosis via electroencephalogram (EEG), but its performance is closely related to the choice of wavelet bases. To overcome this issue, a fusion method of wavelet packet transformation (WPT), Hilbert transform based bidirectional least squares grey transform (HTBiLSGT), modified binary grey wolf optimization (MBGWO) and fuzzy K-Nearest Neighbor (FKNN) was proposed. The HTBiLSGTwas first proposed to model the envelope change of a signal, then WPT based HTBiLSGT was developed for EEG feature extraction by performing HTBiLSGT for each subband of each wavelet level. To select discriminative features, MBGWO was further put forward and employed to conduct feature selection, and the selected features were finally fed into FKNN for classification. The Bonn and CHB-MIT EEG datasets were used to verify the effectiveness of the proposed technique. Experimental results indicate the proposed WPT based HTBiLSGT, MBGWO and FKNN can respectively lead to the highest accuracies of 100% and 98.60 ± 1.35% for the ternary and quinary classification cases of Bonn dataset, it also results in the overall accuracy of 99.48 ± 0.61 for the CHB-MIT dataset, and the proposal is proven to be insensitive to the choice of wavelet bases.
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