The aim of this study was to evaluate the frequency of positive skin prick test (SPT) results to house dust mite (HDM) allergens - perennial inhalant allergens. Material and methods: The study was carried out on 2197 patients of either sex aged 20 - 45 (mean age 32.4 ± 0.1 years). All patients enrolled in this study were allergic to house dust mites. Results: In all patients the following clinical manifestations were found: positive skin (SPT) tests to house dust mite (HDM) allergens. The following allergens were the most common cause of allergic rhinitis in patients admitted to the Clinic of Allergology in the period 1995-2002: Dermatophagoides pteronyssinus, Dermatophagoides farinae, Acarus siro, Lepidoglyphus destructor, Tyrophagus putrescentiae.