Wyniki wyszukiwania - Biblioteka Nauki

1

Mechanisms of immunosuppressive activity of immunoglobulins

100%

Miller A. , Jedrzejczak W. W.

Postępy Higieny i Medycyny Doświadczalnej

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2000

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tom 54

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nr 4

423-444

EN

The article reviews the evidence supporting and explaining suppressive activity of intravenous immunoglobulin (IVIG) preparations towards human immune system. Besides basic mechanisms also clinical applications and effects in various autoimmune disorders such as idiopathic thrombocytopenia, Guillain-Barre syndrom and others are described. This evidence supports novel application of IVIG as convenient alternative to other immunosuppressive therapies with many more adverse effects.

2

Antichlamydial antibodies in the serum and expressed prostatic secretion in prostatitis

80%

Ostaszewska-Puchalska I. , Zdrodowska-Stefanow B. , Badyda J. , Bulhak-Koziol V. , Pucilo K. , Darewicz B.

Archivum Immunologiae et Therapiae Experimentalis

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2004

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tom 52

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nr 4

277-283

EN

The aim of the study was to evaluate the prevalence of anti-Chlamydia trachomatis (C. trachomatis) antibodies in serum and expressed prostatic secretion (EPS) in chronic prostatitis. Thirty-six patients with chronic prostatitis were examined. The presence of C. trachomatis was determined in urethral smears and EPS. Specific antibodies were determined in the serum (IgM, IgA, IgG) and in the EPS (IgA, IgG). In the direct diagnosis of chlamydial infection, the direct immunofluorescence method and the ligase chain reaction were employed, and for the serological diagnosis, the immunoenzymatic method. C. trachomatis infection was detected in the urethra of 3 (8.3%) patients and in the prostatic gland of 3 (8.3%) patients; only one of these patients was found to have C. trachomatis in both the urethra and the EPS. In the control group, C. trachomatis was detected in the urethra of 1/50 (2%) of the men, but the EPS of all of them was free of C. trachomatis. Specific IgM antibodies were found in 7 (19.4%), IgA in 9 (25%), and IgG in 18 (50%) of the patients' serum, whereas IgAs were detected in 12 (33.3%) and IgGs in 13 (36.1%) of the patients' EPS. In the control group, anti-C. trachomatis antibodies of the IgG were detected in the serum of 2/35 (5.7%) of the men, whereas in the EPS neither IgA nor IgG antibodies were detected in any of these patients. Serological tests of the serum and EPS are useful as a complementary method in the diagnosis of chronic prostatitis.

3

Pre-operative levels of serum immunoglobulins, circulating immune complexes and complement proteins in patients with different types of neoplasms

80%

Gendek-Kubiak H. , Grzegorczyk J. , Gendek E. G. , Kowalski M. L. , Berner J.

Archivum Immunologiae et Therapiae Experimentalis

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2001

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tom 49

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nr 2 suppl.

89-96

EN

In the sera of 30 neoplasm patients without metastases, the average IgG level was higher than in the control group (CG) (18.16 + 5.10 versus 12.62 + 2.14 g/l or 12.22 + 2.14 after excluding an out-lier). Average concentrations of CIC, IgM, C1i, C3c and C4 did not statistically differ between the groups. Dividing the patients' group into breast or ovary cancer (BC), melanoma (M), digestive tract cancer (DT) and other neoplasms (ON) subgroups revealed that the IgG increase did not apply to the BC group. Relatively decreased CIC concentrations in the BC and DT group and an increased C1i in the DT group were found. Several diversities detected in the humoral immunity indices' distributions and correlations suggest activation of different mechanisms depending on the neoplasm types.

4

V gene replacement in T and B lymphocytes: illicit or regimented rearrangement?

80%

Golub R.

Archivum Immunologiae et Therapiae Experimentalis

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2002

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tom 50

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nr 4

255-262

EN

Lymphocyte can undergo novel types of secondary genetic rearrangements that alter the specificity of a pre-existing B cell receptor (BCR) or T cell receptor (TCR). V gene replacement is one of them and it replaces an already rearranged V gene segment with an upstream germline V gene segment. This review focuses on the molecular aspect of rearrangement. The role of this mechanism in the immune system is debated.

5

IL-15 and IL-15Ra in CD4+T cell immunity

80%

Van_ B. T. , Grooten J.

Archivum Immunologiae et Therapiae Experimentalis

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2005

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tom 53

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nr 2

115-126

EN

The cytokine IL-15 performs numerous functions, such as promotion of growth and survival, on a plethora of cell types from both the lymphoid and non-lymphoid compartments. Therefore, mice genetically engineered to either lack or overexpress functional IL-15 display reduced immunological responses and leukemia, respectively. Surprisingly, IL-15 protein is hardly found in serum or body fluids. Due to the lack of a clear demonstration of its presence as protein, IL-15 was often referred to as a 'ghost cytokine'. Recently, however, membrane-bound IL-15 was detected in both a membrane-anchored form and an IL-15Ralpha-bound form on monocytes. Interestingly, the latter complex can be transpresented to cells expressing the intermediate-affinity IL-2/15Rbeta- gammaC receptor and thereby support the survival and proliferation of T cells. Moreover, overlapping promoter elements indicate a model of co-regulation of IL-15 and IL-15Ralpha by which IL-15 activities are controlled in a cell-contact-dependent manner. In this review, recent reports on IL-15 are combined with previous observations and discussed in terms of their functional consequences for CD4+ T cell responses.

6

Structure of antibody and limphocytes of receptor T ? similarities and differences

70%

Madalinski K. , Michalkiewicz M. J. , Michalkiewicz J.

Biotechnologia

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2001

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nr 3

71-77

EN

In this paper the structure of molecules responsible for recognition of foreign antigen is given.

7

The use of the Congo red-related dye DBACR to recognize the heavy chain-derived abnormality of myeloma immunoglobulins

70%

Spolnik P. , Konieczny L. , Piekarska B. , Rybarska J. , Stopa B. , Zemanek G. , Drozd A. , Krol M. , Roterman I. , Wolska-Smolen T. , Skotnicki A. B.

Archivum Immunologiae et Therapiae Experimentalis

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2006

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tom 54

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nr 3

217-221

EN

Introduction: The aim of this study was to differentiate heavy and light chain-derived instability of monoclonal myeloma immunoglobulins by complexation of matched supramolecular dyes. These are composed of several micellar pieces of self-assembled dye molecules which may penetrate the protein interior of the binding locus with polypeptide chains. These dyes were used to elicit, by precipitation, the postulated higher aggregation tendency of the heavy chain derived from its higher hydrophobicity. Materials and Methods: Agarose gel electrophoresis was used to create conditions for dye complexation and to reveal the precipitation. Results: Congo red derivatives with aromatic ring substitutes, BACR and DBACR, of increased penetrating capability were chosen to provoke the precipitation of abnormal immunoglobulins by displacing association-prone polypeptide chains from the protein interior. Conclusions: The results of this study confirm the heavy chain-related propensity of some monoclonal immunoglobulins to aggregate and precipitate. The simplicity of the technique may improve clinical diagnosis and facilitate predictions of disease complications.

8

IgG and IgM antigenic markers in sheep

50%

Skiba E. , Wegrzyn J.

Genetica Polonica

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1993

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tom 34

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nr 4

345-355