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Synthesis and characterization of azanonaborane-containing purine derivatives for boron neutron capture therapy

100%

Genady A. , El-Zaria M. , Gabel D.

Open Chemistry

2008

tom 6

nr 2

154-160

Derivatives of purine, adenine, guanine, and 2,6-diaminopurine linked to the azanonaborane (B8N cluster) have been prepared, for possible use as powerful agents for boron neutron capture therapy (BNCT). The synthesis was carried out via a ligand exchange reaction. The exo-NH2R group of the azanonaborane of the type [(RH2N)B8H11NHR] can be exchanged by one hetero-nitrogen atom of the pyrimidine ring, and except for guanine, also by an N atom of the imidazole ring. The identity of the products was confirmed by NMR, elemental analysis, IR, and mass spectrometry. No reaction was found to occur with caffeine and theophylline under the same reaction conditions. [...]

Can N-heterocyclic germylenes behave as Lewis acids - is there another side to Meller germylenes?

63%

Kühl O.

Open Chemistry

2008

tom 6

nr 3

365-372

N-Heterocyclic germylenes are known to exist in two structurally different forms, the planar Meller germylenes and the monoimino germylenes that feature an envelope structure. This essay reviews recent reports dealing with radical and cationic Meller type germylenes featuring the monoimino germylene structure, discusses their transformations and relationships, and asks the question whether indeed N-heterocyclic germylenes can be turned into Lewis acids. [...]

Generation of Molecular Shape Diverstiy. From Privileged Scaffolds to Diverted Total Synthesis

63%

Dai W.-M.

Diversity Oriented Synthesis

2012

tom 1

nr 1

Molecular shape is a presentation of a molecule’s three-dimensional structure and its volume of space and surface electrostatic potential map collectively define the function, e. g. as a modulator or probe to biological targets. Molecular shape diversity for compound libraries with multiple scaffolds (rich skeletal diversity) is recognized as a prerequisite for discovering broad bioactivity. Established strategies and methodologies for diversity-oriented synthesis (DOS) are useful for generating molecular shape diversity by synthesizing natural product-like compounds. On the other hand, diverted total synthesis (DTS) offers natural products and analogues with a higher degree of structural diversity and complexity. Examples of DOS of privileged heterocycles and DTS of amphidinolide T marine macrolides from the author’s laboratories are illustrated.