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2 Acta Physiologica Polonica

2 1990

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Motor nucleus of the V-th nerve and the control of breathing. Breuer-Hering reflexes and apneustic breathing

100%

Gromysz H. , Karczewski A. W. , Jernajczyk U.

nr 7

Gromysz H., Karczewski W. A., Jernajczyk U.: Motor nucleus of the V-th nerve and the control of breathing. Brener-Hering reflexes and apneustic breathing. Acta Physiol. Pol. Earlier studies from this department have demonstrated that neurones of the V-th nerve motor nucleus (NVmt) have oligosynaptic, inhibitory output to the inspiratory motoneurone themselves under the influence of a polysynaptic input from vagal afferents. To check the hypothesis that NVmt is a part of the pneumotaxic mechanism, we studied the effects of pharmacological microblockade of the NVmt on Breuer-Hering reflexes in halothane-anesthetized, paralyzed and artificially ventilated rabbits. Activities of NVmt neurones and phrenic nerve firing were recorded. Acid-base balance was controlled and histologic examinations were routinely performed. Expiratory activities were regulatory found in NVmt. Its blockade elicited a typical apneustic breathing. During the blockade the Breuer-Hering reflexes gave “paradoxical” effects: an increase in central respiratory frequency following inflation, inspiratory apneusis in response to deflation. We conclude that the NVmt is an important component of the pneumotaxic mechanism or even the anatomical substrate of the pneumotaxic “centre”.

Breuer-Hering reflexes in ketamine-induced apneustic breathing in the rabbit

86%

Gromysz H. , Karczewski W. A. , Kukwa A. , Jernajczyk U.

nr 7

Gromysz H., Karczewski W. A., Kukwa A., Jernajczyk U.: Breuer-Hering reflexes in ketamine-induced apneustic breathing in the rabbit. Acta Physiol. Pol. The effects of ketamine on the activities of the mylohyoid nerve (a branch of the Vth nerve) and of both phrenic nerves were investigated in rabbits anaesthetized with halothane, paralyzed and artificially ventilated. Intravenous administration of ketamine elicited a marked prolongation of the phrenic inspiratory discharge [without] not significantly affecting its amplitude) and a depression of the mylohyoid expiratory activity. An elimination of the volume-related input from the lungs (“no inflation manoeuvre” or deflation) elicited under these conditions typical apneustic pattern of breathing. The response to tracheal occlusion at peak-inspiration was “classical”. We conclude that ketamine inhibits the Vth nerve motor nucleus which is not only an important component of the central inspiratory-inhibitory neurones but also a “relay station” between the vagal and the central inspiratory “off-switch” mechanisms.