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1 Postępy Higieny i Medycyny Doświadczalnej

1 1995

1 Kolonko A.

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Glutamate receptors in the central nervous system

100%

Kolonko A.

nr 6

719-731

A lot of clinical processes following excessive stimulation of glutamate receptors seem to participate in pathophysiology of numerous acute and chronic neurologicla disorders.The whole of these reactions has been named as "glutamate cascade", because of the central role of glutamate in initiation and intensification of these processes.In this article, classification of different types of glutamate receptors and several hypotheses concerning mechanisms of glutamate neurotoxic activity are presented.A wide variety of neurological diseases, which etiologies are more or less connected with glutamate toxicity are discussed. At last, the future perspecives for treatment by drugs which action is though to be mediated through glutmate receptord are persented.