The research focuses on the temporal and spatial variation of PM2.5 health burden of Henan Province from 2014 to 2021. The Global Exposure Mortality Model was used to estimate the health burden attributed to PM2.5. The results are as follows: The concentration of PM2.5 showed a significant downward trend, with a spatial distribution pattern of higher in the north and the east but lower in the south and the west. The exposed population showed a decreasing trend. The overall frequency of PM2.5 concentration decrease was 0.13 μg·m-3/a. The number of PM2.5 – attributable mortality decreased from 86,297 in 2014 to 82,667 in 2021. Ischemic heart disease had the highest number of attributable mortality, with an average of 55,072 deaths per year. Chronic obstructive pulmonary disease and lung cancer had relatively high numbers, while respiratory tract infections were lower, with an average of 4,034 deaths per year.
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