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NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzyme.

100%

Borowski P. , Niebuhr A. , Schmitz H. , Hosmane R. S. , Bretner M. , Siwecka M. A. , Kulikowski T.

tom 49

nr 3

597-614

RNA nucleoside triphosphatases (NTPase)/helicases represent a large family of proteins that are ubiquitously distributed over a wide range of organisms. The enzymes play essential role in cell development and differentiation, and some of them are involved in transcription and replication of viral single-stranded RNA genomes. The enzymatic activities of a NTPase/helicase were also detected in the carboxyl-terminal non-structural protein 3 (NS3) of members of the Flaviviridae family. The crucial role of the enzyme for the virus life cycle was demonstrated in knock out experiments and by using NTPase/helicase specific inhibitors. This makes the enzyme an attractive target for development of Flaviviridae-specific antiviral therapies. This review will summarize our knowledge about the function and structure of the enzyme, update the spectrum of inhibitors of the enzymatic activities of the NTPase/helicase and describe the different mechanisms by which the compounds act. Some of the compounds reviewed herein could show potential utility as antiviral agents against Flaviviridae viruses.

Nowe inhibitory cyklu rozwojowego wirusow rodziny Flaviviridae.

80%

Bretner M. , Felczak K. , Siwecka M. A. , Kulikowski T.

tom 14

50-52

The first detection of the tick-borne encephalitis virus (TBEV) RNA in Dermacentor reticulatus ticks collected from the lowland European bison (Bison bonasus bonasus L.)

51%

Biernat B. , Karbowiak G. , Stanczak J. , Masny A. , Werszko J.

tom 61

nr 1

NTPase-helicase of Flaviviridae: inhibitors and inhibition of the enzyme

41%

Borowski P. , Niebuhr A. , Schmitz H. , Hosmane R. S. , Bretner M. , Siwecka M. A. , Kulikowski T.

nr 3

RNA nucleoside triphosphatases (NTPase)/helicases represent a large family of proteins that are ubiquitously distributed over a wide range of organisms. The enzymes play essential role in cell development and differentiation, and some of them are involved in transcription and replication of viral single-stranded RNA genomes. The enzymatic activities of a NTPase/helicase were also detected in the carboxyl-terminal non-structural protein 3 (NS3) of members of the Flaviviridae family. The crucial role of the enzyme for the virus life cycle was demonstrated in knock out experiments and by using NTPase/helicase specific inhibitors. This makes the enzyme an attractive target for development of Flaviviridae-specific antiviral therapies. This review will sum-marize our knowledge about the function and structure of the enzyme, update the spectrum of inhibitors of the enzymatic activities of the NTPase/helicase and describe the different mechanisms by which the compounds act. Some of the compounds reviewed herein could show potential utility as antiviral agents against Flaviviridae viruses.