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Cloning and purification of functionally active Fas ligand interfering protein (FIP) expressed in Escherichia coli

100%

Wisniewski P. , Master A. , Kaminska B.

Acta Biochimica Polonica

2008

tom 55

nr 1

51-56

This report presents purification and characterization of the extracellular domain of rat Fas protein, called FIP (FasL interfering protein), expressed as inclusion bodies in Escherichia coli. FIP was extracted from the inclusion bodies, solubilized with 8 M urea, purified by a single-step immobilized metal ion (Ni2+) affinity chromatography and refolded. SDS/PAGE and mass spectrometry analysis of the purified protein verified its purity. Fluorescence spectrum analysis showed that the refolding procedure caused structural changes which presumably might have led to oligomerization. The purified FIP has biological activities: it binds specifically soluble Fas ligand and protects human Jurkat lymphocytes against FasL-dependent apoptosis. This efficient procedure of FIP expression in E. coli and renaturation may be useful for production of therapeutically important proteins.

Apoptoza w ukladzie odpornosciowym - rola Fas, bcl-2 i interlekiny 2

86%

Rolinski J.

Postępy Biologii Komórki

1997

tom 24

nr 4

561-574

Helicobacter pylori increases expression of proapoptotic markers Fas and FasL on CD4 lymphocytes in children

86%

Kotłowska-Kmieć A. , Bąkowska A. , Szarszewski A. , Kamińska B. , Łuczak G. , Radys W. , Landowski P. , Brodzicki J. , Korzon M. , Liberek A.

Acta Biochimica Polonica

2009

tom 56

nr 3

433-438

The pathomechanism of Helicobacter pylori action upon gastric mucosa and its role in the pathogenesis of gastritis have not been fully elucidated. The aim of this study was to evaluate the most prevalent lymphocyte subpopulations of the gastric mucosa in gastritis in children, as well as to evaluate the expression of Fas and Fas ligand receptors (FasL), periapoptotic markers of gastric mucosa lymphocytes before and after H. pylori eradication. Forty nine patients aged 6 to 17 years, investigated due to chronic abdominal pain, were studied. The obtained tissue samples were analysed by immunohistochemistry. Different lymphocyte subsets were quantified on the basis of surface antigen expression (CD3, CD4, CD8, CD20), secreted cytokines (IL-4, IL-6, IFNγ) and Fas and FasL proteins in the gastric mucosa. B and T helper lymphocytes were found to play a major role in the inflammatory infiltration in the gastric mucosa in children during H. pylori infection. Their expression was found to decrease after eradication. The enhanced expression of Fas receptor on lymphocytes before treatment and a decrease of this expression after eradication of H. pylori were shown. It was demonstrated that there is a correlation between CD4 and Fas receptor expression that may induce apoptosis of the helper lymphocytes in infected children.

The city of Fas and the University of al-Qarawiyyin: a common destiny

71%

Edaich S.

Opolskie Studia Administracyjno-Prawne

2018

tom 16

nr 4 (1)

237-250

Historia ludzkości wiąże się z istnieniem koncepcji przestrzennych, miejsc będących państwami, miastami lub innymi formami organizacyjnymi. Badania nad Rzymem i Atenami, Bagdadem i Damaszkiem dostarczają obfitych informacji mających bezpośredni wpływ na zrozumienie ewolucji cywilizacji ludzkiej. Fas – miasto maurejskie, które zainicjowało marokańskie państwo, zawsze wzbudzało zainteresowanie historyków i specjalistów. Jest to unikalny model społeczny i miasto, dzięki któremu Uniwersytet Al-Qarawiyyin był w stanie przetrzymać wszelkie surowe zmiany. Niniejszy artykuł ma na celu śledzenie jego ewolucji, z uwzględnienim ekspansji i dominacji historycznej w Afryce Północnej i Europie na przestrzeni wieków.

Human history has always been linked to a spatial concept, a place that can be a state, a city, or any other geographical determination. The researches on Rome and Athens, Baghdad and Damascus provide ample information with a direct impact on understanding the evolution of human civilization. Fas, the Moorish city which initiated the Moroccan State, has always aroused the interest of historians and specialists. It is a unique social model and a city that has been able, thanks to its University Al-Qarawiyyin, to withstand all the harsh changes for centuries. This paper is intended to follow the evolution of this city through the expansion and historical dominance in North Africa and Europe throughout centuries.