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Protective effect of pantothenic acid and related compounds against permeabilization of Ehrlich ascites tumour cells by digitonin

100%

Slyshenkov V. S. , Rakowska M. , Wojtczak L.

nr 2

Preincubation of Ehrlich ascites tumour cells with millimolar concentrations of pantothenic acid, pantothenol or pantethine, but not with homopantothenic acid, at 22°C or 32°C, but not at 0°C, makes the plasma membrane more resistant to the damaging effect of submillimoiar concentrations of digitonin. It is proposed that this increased resistance is due to the increased rate of cholesterol biosynthesis. In fact, incorporation of [14C]acetate into cholesterol is by 45% increased in the cells preincubated with pantothenic acid; this probably reflects elevation of the content of CoA in such cells [Slyshenkov, V.S., Rakowska, M., Moiseenok, A.G. & Wojtczak, L. (1995) Free Radical Biol. Med. 19,767-772].

Ultrastructural changes of Ehrlich ascites tumor cells after intraperitoneal recombinant human tumor necrosis factor-alpha administration

72%

Terlikowski S. J. , Sulkowski S. T.

nr 2

Swiss albino male mice were inoculated intraperitoneally (i.p.) with Ehrlich ascites tumor (EAT) and treated i.p. with recombinant human tumor necrosis factor-α (rhTNF-) three time a week in doses of 5, 7.5 and 10μg for 2 weeks, respectively. The effect of the cytokine on EAT was evaluated by the rate of tumor growth inhibition and ultrastructural changes in EAT cell. After the applied doses of rhTNF-α, inhibition of tumor growth was found. The number of EAT cells decreased after 7.5 and 10μg of rhTNF-α (P<0.001). Ultrastructural study demonstrated a cytotoxic effect of the cytokine on EAT cells.