A review of the metabolic pathways and interaction with DNA of benzo(a)pyrene and some other carcinogens is presented. Consideration is given to the formation and persistens of adducts in relation to carcinogenic process.
The techniques applicable for identification and quantitation are critically reviewed. The review also present the data concerning an analysis of DNA adducts resulted from occupational exposure, tobacco smoking, diet and chemotherapy of tumors.
Cis-DDP is an with activity against various . It is generally accepted that is the of cis-DDP. The present paper describes the binding models of cis-DDP to DNA, structural distortion in DNA induced by covalent binding of cis-DDP and repair studies of Pt-DNA adducts in pro- and eucariotic systems. We also discuss the possible mechanisms of acquired of to cis-DDP and analoques, and potential clinical implication of this fenomenon.
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