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Synthesis, Spectral Studies Antibacterial and Antifungal Activity of 2" – Amino - 4" - [2 - (4' -chlorophenyl)-6-methyl imidazo[1, 2-a] pyridin-3-yl]-6"-aryl Nicotinonitrile

100%

Bhuva V. V. , Bhadani V. N. , Purohit H. D. , Purohit D. M.

International Letters of Chemistry, Physics and Astronomy

2015

tom Vol. 49

161--166

Pyridine nucleus plays an important role in medicine, agriculture and industrial chemistry. With a view of biological activities and variety of industrial applications, some new 2" – amino - 4" - [2 - (4' -chlorophenyl)-6-methyl imidazo [1, 2-a] pyridin-3-yl]-6"-aryl nicotinonitriles ( 4a-4l ) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/ml. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.

Novel s-Triazinyl Schiff Base/Chalcone Congeners: Rational, Synthesis, Antimicrobial and Anti-TB Evaluation

88%

Lakum H. P. , Shah D. R. , Chikhalia K. H.

tom Vol. 19, iss. 1

56--73

The occurrence of Multi Drug Resistant (MDR) infectious microbial strains has been increased upto alarming level which affects the public health worldwide. To cure this problem, a library of s-triazinyl derivatives comprising schiff base or chalcone motif have been rationalized, synthesized and screened for their in vitro antibacterial activity against five bacterial strains (Staphylococcus aureus MTCC 96, Bacillus subtilis MTCC 441, Escherichia coli MTCC 739, Pseudomonas aeruginosa MTCC 741 and Klebsiella pneumoniae MTCC 109) and four fungal strains (Aspergillus niger MTCC 282, Aspergillus fumigates MTCC 343, Aspergillus clavatus MTCC 1323, Candida albicans MTCC 183) using broth dilution technique. All the newly synthesized scaffolds were further evaluated for their in vitro anti-TB efficacy against the tubercular strain (Mycobacterium tuberculosis H37Rv) using Lowenstein-Jensen MIC method. All the derivatives were well characterized by IR, 1H NMR, 13C NMR, elemental analysis as well as mass spectroscopy.

Synthesis, Characterization, In-Vitro Antimicrobial Evaluation and Antioxidant Studies of Some Isoxazoline Derivatives

75%

Vishnupriya P. , Rubala mary M.

nr 2

72-78

The tremendous rise in development of resistance to antimicrobials has created an alarming situation for researchers and clinicians. In this regard, an attempt has been made to develop a series of azole-based derivatives. The presented study consists of the design and synthesis of some newer derivatives by incorporating the isoxazole nucleus in the pharmacophore. These are also characterized physicochemically and by spectral means (IR and microanalysis). Moreover, the antioxidant activity of these derivatives was assessed using DPPH radical scavenging methods Finally, all of the newly isolated compounds were tested for their antimicrobial activities. Herein, antimicrobial screening using the agar disc diffusion method revealed that the majority of the derivatives are most active.