Wyniki wyszukiwania - Biblioteka Nauki

Ten serwis zostanie wyłączony 2025-02-11.

Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

Ograniczanie wyników

5 Journal of Applied Genetics

Znaleziono wyników: 5

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: CHROMOSOMAL ABERRATION

Sortuj według:

Ogranicz wyniki do:

Clastogenic and mitodepressive effects of the insecticide dichlorvos on root meristems of Vicia faba

100%

Kontek R. , Osiecka R. , Kontek B.

2007

tom 48

nr 4

359-361

Plant bioassays are an important and integral part of the test battery used in detecting genotoxic/carcinogenic contamination in the environment. Highly sensitive biomonitoring of plant models have been developed, which enables the detection of hazards arising from pesticides, insecticides, industrial contamination, heavy metals and radiation. Root tips of Vicia faba ssp. minor were treated with 1?60 mM of the organophosphorus insecticide dichlorvos (DDVP) for 2 h, followed by a 20-h recovery period. Maleic acid hydrazide (MH) was used as a positive control for the mitotic index, micronucleus and chromosomal aberration assays performed on the Vicia model system. All treatments with DDVP significantly decreased the mitotic activity and increased the frequency of chromosomal aberrations at the metaphase. The frequency of micronuclei was significantly increased at DDVP concentrations starting from 10 mM. The results demonstrate clastogenic and mitodepressive effects of DDVP on Vicia faba cells.

Manifestations of ageing at the cytogenetic level

100%

Wojda A. , Witt M.

Journal of Applied Genetics

2003

tom 44

nr 3

383-399

The effects of ageing in humans appear to be a combination of influence of genetically programmed phenomena and exogenous environmental factors, and take place at the cellular level (senescence), rather than at the level of the organism. There are many processes, which occur in somatic cells as a consequence of DNA replication (accumulation of DNA errors or mutations that outstrip repair processes, telomere shortening, deregulation of apoptosis, etc.) and which drive replicative senescence in human cells. DNA errors are considered to be critical primary lesions in the formation of chromosomal aberrations. It can be concluded that the chromosome aberrations are biomarkers of ageing in human cells. Studies of human metaphases, interphase nuclei and micronuclei showed the increase in loss of chromosomes and the increase in frequency of stable chromosome aberrations as a function of age.

The 102-year old woman with translocation (7;12) and infertility in anamnesis

100%

Wojda A. , Wolnik-Brzozowska D. , Lubka M. , Mossakowska M. , Witt M.

Journal of Applied Genetics

2003

tom 44

nr 3

425-427

In this study we present a 102-year old woman carrying a (7;12)(q11.3;q14) translocation. A woman displays a normal phenotype and infertility in anamnesis. This is the first report linking t(7;12) and infertility.

Influence of cysteine on mechlorethamine-induced chromosomal aberrations in cultured human lymphocytes

75%

Blaszczyk A.

1995

tom 36

nr 4

389-393

The aim of the present paper was to find out by in vitro chromosomal aberration test using human lumphocytes whether cysteine has anticlastogenic properties towards a well-known mutagen - mechlorethamine.The lymphocytes tested were obtained rom three healthy donors.Two doses of cysteine and three doses of mechlorethamine were tested.It was found that cysteine had anticlastogenic properites and that it reduced the number of mrthaphase with chromosomal aberrations induced by mechlorethamine.

Cytogenetic perspective of ageing and longevity in men and women

63%

Zietkiewicz E. , Wojda A. , Witt M.

Journal of Applied Genetics

2009

tom 50

nr 3

261-273

Analysis of relationships between the ageing cell phenotype and the age of cell donors is one of the ways towards understanding the link between cellular and organismal ageing. Cytogenetically, ageing is associated with a number of gross cellular changes, including altered size and morphology, genomic instability, and changes in expression and proliferation. Genomic instability can be easily assessed by analyzing the level of cytogenetic aberrations. In this review, we focus on the differences in the level and profile of cytogenetic aberrations observed in donors of different age and gender. Centenarians are a small fraction of the population at the extreme of human longevity. Their inclusion in such studies may shed light on one of the basic questions: whether genome stability is better maintained in successfully aged individuals compared to the rest of the population. At the same time, comparing the profile of age-related amount of chromosomal aberrations in men and women may help explaining the commonly observed gender differences in longevity.