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Significance of Bax Expression in Breast Cancer Patients

100%

Pluta P. , Smolewski P. , Pluta A. , Cebula-Obrzut B. , Wierzbowska A. , Nejc D. , Robak T. , Kordek R. , Gottwald L. , Piekarski J. , Jeziorski A.

Polish Journal of Surgery

2011

tom 83

nr 10

549-553

Bax protein, the proapoptotic member of Bcl-2 protein family, plays the key role in apoptosis pathway.The aim of the study was to assess the expression of Bax protein in breast cancer cells.Material and methods. Sixty-two breast cancer patients were included in the study. The control group encompassed 11 fibroadenoma patients. Single cells were isolated from defrosted samples and prepared for flow cytometry measurement.Results. Median expression of Bax protein in study group was 7.9% (range: 0-49.4%) and was significantly lower than in control (median expression 15.8%; range 4.9-30.9%; p=0.034). Expression of Bax correlated with expression of p53 and caspase-3 proteins (p<0,01, rank Spearman test). In patients under 70 years old and with positive estrogen receptors status the expression of Bax protein was significantly higher (p=0.03 and p=0.01 respectively).Conclusions. Lower expression of Bax protein in breast cancer cells may suggest the potential way of apoptosis avoidance of tumor cells. Correlations among Bax protein, p53 and caspase-3 are likely associated with active apoptotic mechanism in breast cancer cells expressing Bax protein. Further investigation with long time follow-up should be performed to establish the prognostic role of Bax protein expression in breast cancer patients.

Mitochondrial heat shock response induced by ectromelia virus is accompanied by reduced apoptotic potential in murine L929 fibroblasts

63%

Wyzewski Z. , Gregorczyk-Zboroch K. P. , Mielcarska M. B. , Bossowska-Nowicka M. , Struzik J. , Szczepanowska J. , Toka F. N. , Niemialtowski M. G. , Szulc-Dabrowska L.

Archivum Immunologiae et Therapiae Experimentalis

2019

tom 67

nr 6

The miR-1204 regulates apoptosis in NSCLC cells by targeting DEK

63%

Qian Z. , Yang J. , Liu H. , Yin Y. , Hou L. , Hu H.

Folia Histochemica et Cytobiologica

2019

tom 57

nr 2

Expression of Bcl-2 and Bax proteins in thyroid glands of rats in experimental thyroiditis

63%

Markovic L. , Todorovic J. , Stankovic G. , Radojevic S. , Gvozdenovic E. , Aritonovic J. , Stupar N. , Vojinovic Maglic G.

Folia Biologica

2010

tom 58

nr 3-4

163-169

Changes of Bcl-2, Bax and Caspase-3 expression in the dermal microvascular endothelial cells and the epidermal layers of the eschar (tache noire) in patients with Mediterranean spotted fever

63%

Baltadzhiev I. , Delchev S.

Folia Histochemica et Cytobiologica

2013

tom 51

nr 2

Neuropathic alterations of the myenteric plexus neurons following subacute intraperitoneal administration of salsolinol

63%

Kurnik M. , Gil K. , Gajda M. , Thor P. , Bugajski A.

Folia Histochemica et Cytobiologica

2015

tom 53

nr 1

The effect of octreotide and bromocriptine on expression of a pro-apoptotic Bax protein in rat prolactinoma

63%

Gruszka A. , Kunert-Radek J. , Pawlikowski M.

Folia Histochemica et Cytobiologica

2004

tom 42

nr 1

Translocation of apoptosis-related proteins in MCF-7 cells exposed to camptothecin in the mitochondrial pathway of apoptosis

63%

Gajkowska B. , Wojewodzka U. , Walski M. , Frontczak-Baniewicz M.

Acta Biologica Cracoviensia. Series Zoologia

2003

tom 45

Expression of leptin and its receptor in female breast cancer in relation with selected apoptotic markers

51%

Koda M. , Sulkowska M. , Kanczuga-Koda L. , Jarzabek K. , Sulkowski S.

Folia Histochemica et Cytobiologica. Supplement

2007

tom 45

nr 1

187-191

Evaluation of apoptotic activity of new condensed pyrazole derivatives

44%

Toton E. , Ignatowicz E. , Bernard M. K. , Kujawski J. , Rybczynska M.

Journal of Physiology and Pharmacology

2013

tom 64

nr 1